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Atp6v0c ATPase H+ transporting V0 subunit C [ Rattus norvegicus (Norway rat) ]

Gene ID: 170667, updated on 11-Apr-2024

Summary

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Official Symbol
Atp6v0cprovided by RGD
Official Full Name
ATPase H+ transporting V0 subunit Cprovided by RGD
Primary source
RGD:621394
See related
Ensembl:ENSRNOG00000006542 AllianceGenome:RGD:621394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atp6c; Atp6l
Summary
Predicted to enable ubiquitin protein ligase binding activity. Involved in negative regulation of autophagic cell death and positive regulation of ERK1 and ERK2 cascade. Located in Golgi apparatus; lysosome; and synaptic vesicle. Human ortholog(s) of this gene implicated in thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 334.0), Brain (RPKM 332.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Atp6v0c in Genome Data Viewer
Location:
10q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13700764..13707147, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13196204..13202580, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13537031..13543407, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene 3-phosphoinositide dependent protein kinase-1 Neighboring gene amidohydrolase domain containing 2 Neighboring gene TBC1 domain family, member 24 Neighboring gene netrin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Chromophore-Assisted Light Inactivation of the V-ATPase V0c Subunit Inhibits Neurotransmitter Release Downstream of Synaptic Vesicle Acidification. Rama S, et al. Mol Neurobiol, 2019 May. PMID 30155790
  2. Protective effects of vacuolar H+ -ATPase c on hydrogen peroxide-induced cell death in C6 glioma cells. Byun YJ, et al. Neurosci Lett, 2007 Oct 2. PMID 17845832
  3. Molecular cloning of a rat liver cDNA encoding the 16 kDa subunit of vacuolar H(+)-ATPases: organellar and tissue distribution of 16 kDa proteolipids. Nezu J, et al. J Biochem, 1992 Aug. PMID 1400263
  4. PFKFB2 Promoter Hypomethylation as Recurrence Predictive Marker in Well-Differentiated Thyroid Carcinomas. Camargo Barros-Filho M, et al. Int J Mol Sci, 2019 Mar 16. PMID 30884810, Free PMC Article
  5. The V0 sector of the V-ATPase, synaptobrevin, and synaptophysin are associated on synaptic vesicles in a Triton X-100-resistant, freeze-thawing sensitive, complex. Galli T, et al. J Biol Chem, 1996 Jan 26. PMID 8567678

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. V-ATPase c-subunit V0c is a key element in modulating neurotransmission and that its specific inactivation rapidly inhibited neurotransmission.
    Title: Chromophore-Assisted Light Inactivation of the V-ATPase V0c Subunit Inhibits Neurotransmitter Release Downstream of Synaptic Vesicle Acidification.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of autophagic cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
part_of proton-transporting V-type ATPase complex ISO
Inferred from Sequence Orthology
more info
  
part_of proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic vesicle membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
part_of transmembrane transporter complex ISO
Inferred from Sequence Orthology
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
V-type proton ATPase 16 kDa proteolipid subunit c
Names
ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit C
ATPase, H+ transporting, lysosomal 1
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
ATPase, H+ transporting, lysosomal V0 subunit C
V-ATPase 16 kDa proteolipid subunit
V-ATPase 16 kDa proteolipid subunit c
V-type proton ATPase 16 kDa proteolipid subunit
vacuolar proton pump 16 kDa proteolipid subunit
vacuolar proton pump 16 kDa proteolipid subunit c
NP_570836.1
XP_006245960.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130823.4 → NP_570836.1  V-type proton ATPase 16 kDa proteolipid subunit c

    See identical proteins and their annotated locations for NP_570836.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P63081
    UniProtKB/TrEMBL
    A0A8L2Q4M1, A6HCQ5
    Related
    ENSRNOP00000088542.1, ENSRNOT00000113937.1
    Conserved Domains (2) summary
    TIGR01100
    Location:13 → 118
    V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
    cd18176
    Location:86 → 153
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    13700764..13707147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245898.2 → XP_006245960.1  V-type proton ATPase 16 kDa proteolipid subunit c isoform X1

    See identical proteins and their annotated locations for XP_006245960.1

    UniProtKB/Swiss-Prot
    P63081
    UniProtKB/TrEMBL
    A0A8L2Q4M1, A6HCQ5
    Conserved Domains (2) summary
    TIGR01100
    Location:13 → 118
    V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
    cd18176
    Location:86 → 153
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63081.1 GenPept UniProtKB/Swiss-Prot:P63081

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