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Adgrl3 adhesion G protein-coupled receptor L3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170641, updated on 13-Apr-2024

Summary

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Official Symbol
Adgrl3provided by RGD
Official Full Name
adhesion G protein-coupled receptor L3provided by RGD
Primary source
RGD:620836
See related
Ensembl:ENSRNOG00000030149 AllianceGenome:RGD:620836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lec3; Cirl3; Lphn3; CIRL-3
Summary
Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in brain development. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in axon; cell-cell junction; and glutamatergic synapse. Predicted to be integral component of plasma membrane. Orthologous to human ADGRL3 (adhesion G protein-coupled receptor L3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 164.5), Lung (RPKM 131.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14p21
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (26690891..27458132, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (26336320..27104060, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (28362176..29226085, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ferritin light chain 1-like Neighboring gene uncharacterized LOC108352732 Neighboring gene uncharacterized LOC134481836 Neighboring gene uncharacterized LOC108352841 Neighboring gene uncharacterized LOC134481835 Neighboring gene uncharacterized LOC134481900 Neighboring gene uncharacterized LOC134481737

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity. Regan SL, et al. Genes Brain Behav, 2022 Sep. PMID 35985692, Free PMC Article
  2. A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats. Regan SL, et al. Neurobiol Dis, 2021 Oct. PMID 34352385, Free PMC Article
  3. Enhanced Transient Striatal Dopamine Release and Reuptake in Lphn3 Knockout Rats. Regan SL, et al. ACS Chem Neurosci, 2020 Apr 15. PMID 32203648
  4. Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers. Regan SL, et al. Neurobiol Dis, 2019 Oct. PMID 31176715, Free PMC Article
  5. LPHN3, a presynaptic adhesion-GPCR implicated in ADHD, regulates the strength of neocortical layer 2/3 synaptic input to layer 5. O'Sullivan ML, et al. Neural Dev, 2014 Apr 17. PMID 24739570, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity.
    Title: Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity.
  2. A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats.
    Title: A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats.
  3. Enhanced Transient Striatal Dopamine Release and Reuptake in Lphn3 Knockout Rats.
    Title: Enhanced Transient Striatal Dopamine Release and Reuptake in Lphn3 Knockout Rats.
  4. new Lphn3 knockout-out rat data collectively show that its disruption is significantly correlated with hyperactivity and associated striatal changes in dopamine markers.
    Title: Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in locomotion involved in locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of postsynaptic specialization structure ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in response to cocaine ISO
Inferred from Sequence Orthology
more info
  
involved_in synapse assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synapse organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor L3
Names
calcium-independent alpha-latrotoxin receptor 3
calcium-independent alpha-latrotoxin receptor homolog 3
latrophilin-3
lectomedin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130822.2 → NP_570835.2  adhesion G protein-coupled receptor L3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    O88924, O88925, O88926, O88927, O88928, O88929, Q4LDM4, Q4LDM5, Q4LDM6, Q4LDM7, Q4LDM8, Q9Z173
    UniProtKB/TrEMBL
    A0A8I6GLK1
    Related
    ENSRNOP00000096360.1, ENSRNOT00000100277.1
    Conserved Domains (5) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    PLN03059
    Location:111 → 191
    PLN03059; beta-galactosidase; Provisional
    smart00303
    Location:881 → 933
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:562 → 626
    HormR; Domain present in hormone receptors
    cd16005
    Location:941 → 1207
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    26690891..27458132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272835.1 → XP_063128905.1  adhesion G protein-coupled receptor L3 isoform X20

  2. XM_063272833.1 → XP_063128903.1  adhesion G protein-coupled receptor L3 isoform X18

  3. XM_063272832.1 → XP_063128902.1  adhesion G protein-coupled receptor L3 isoform X17

  4. XM_063272834.1 → XP_063128904.1  adhesion G protein-coupled receptor L3 isoform X19

  5. XM_063272831.1 → XP_063128901.1  adhesion G protein-coupled receptor L3 isoform X13

  6. XM_063272830.1 → XP_063128900.1  adhesion G protein-coupled receptor L3 isoform X12

  7. XM_063272829.1 → XP_063128899.1  adhesion G protein-coupled receptor L3 isoform X11

  8. XM_063272828.1 → XP_063128898.1  adhesion G protein-coupled receptor L3 isoform X10

  9. XM_063272823.1 → XP_063128893.1  adhesion G protein-coupled receptor L3 isoform X7

  10. XM_063272820.1 → XP_063128890.1  adhesion G protein-coupled receptor L3 isoform X3

  11. XM_039091582.2 → XP_038947510.1  adhesion G protein-coupled receptor L3 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZV15, A6JCT5
    Related
    ENSRNOP00000083229.1
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:863 → 915
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:557 → 621
    HormR; Domain present in hormone receptors
    cd16005
    Location:923 → 1180
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1180 → 1509
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:629 → 837
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  12. XM_063272822.1 → XP_063128892.1  adhesion G protein-coupled receptor L3 isoform X5

  13. XM_039091579.2 → XP_038947507.1  adhesion G protein-coupled receptor L3 isoform X6

    UniProtKB/TrEMBL
    A6JCT5
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:876 → 928
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:557 → 621
    HormR; Domain present in hormone receptors
    cd16005
    Location:936 → 1193
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1193 → 1522
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:629 → 850
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  14. XM_039091587.2 → XP_038947515.1  adhesion G protein-coupled receptor L3 isoform X16

    UniProtKB/TrEMBL
    A0A8I5ZWD6, A6JCU0
    Related
    ENSRNOP00000084026.1
    Conserved Domains (7) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:876 → 928
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:557 → 621
    HormR; Domain present in hormone receptors
    cd16005
    Location:936 → 1193
    7tmB2_Latrophilin-3; Latrophilin-3, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1193 → 1256
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:629 → 850
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  15. XM_063272821.1 → XP_063128891.1  adhesion G protein-coupled receptor L3 isoform X4

  16. XM_039091585.2 → XP_038947513.1  adhesion G protein-coupled receptor L3 isoform X15

    UniProtKB/TrEMBL
    A6JCU0
    Conserved Domains (8) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:876 → 928
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:557 → 621
    HormR; Domain present in hormone receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1202 → 1265
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:629 → 850
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:938 → 963
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:936 → 1202
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  17. XM_017599059.3 → XP_017454548.1  adhesion G protein-coupled receptor L3 isoform X1

    UniProtKB/TrEMBL
    A6JCT7

  18. XM_039091584.2 → XP_038947512.1  adhesion G protein-coupled receptor L3 isoform X14

    UniProtKB/TrEMBL
    F1LRG7
    Conserved Domains (8) summary
    smart00284
    Location:200 → 456
    OLF; Olfactomedin-like domains
    smart00303
    Location:876 → 928
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:557 → 621
    HormR; Domain present in hormone receptors
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1202 → 1309
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:629 → 850
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd14964
    Location:938 → 963
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:936 → 1202
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  19. XM_008769970.4 → XP_008768192.1  adhesion G protein-coupled receptor L3 isoform X2

    UniProtKB/TrEMBL
    A6JCT7, D4AAL4
    Related
    ENSRNOP00000045365.6
    Conserved Domains (8) summary
    smart00284
    Location:205 → 461
    OLF; Olfactomedin-like domains
    smart00303
    Location:881 → 933
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:562 → 626
    HormR; Domain present in hormone receptors
    COG0531
    Location:951 → 1178
    PotE; Amino acid transporter [Amino acid transport and metabolism]
    pfam00002
    Location:941 → 1186
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02140
    Location:111 → 191
    Gal_Lectin; Galactose binding lectin domain
    pfam02354
    Location:1207 → 1579
    Latrophilin; Latrophilin Cytoplasmic C-terminal region
    pfam16489
    Location:635 → 853
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  20. XM_063272826.1 → XP_063128896.1  adhesion G protein-coupled receptor L3 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZV15

  21. XM_063272818.1 → XP_063128888.1  adhesion G protein-coupled receptor L3 isoform X1

  22. XM_063272825.1 → XP_063128895.1  adhesion G protein-coupled receptor L3 isoform X7

  23. XM_063272827.1 → XP_063128897.1  adhesion G protein-coupled receptor L3 isoform X9

  24. XM_063272824.1 → XP_063128894.1  adhesion G protein-coupled receptor L3 isoform X7

  25. XM_063272819.1 → XP_063128889.1  adhesion G protein-coupled receptor L3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z173.1 GenPept UniProtKB/Swiss-Prot:Q9Z173

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