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Slc16a10 solute carrier family 16 member 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 170566, updated on 11-Apr-2024

Summary

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Official Symbol
Slc16a10provided by RGD
Official Full Name
solute carrier family 16 member 10provided by RGD
Primary source
RGD:69197
See related
Ensembl:ENSRNOG00000000588 AllianceGenome:RGD:69197
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tat1
Summary
Predicted to enable thyroid hormone transmembrane transporter activity. Predicted to be involved in aromatic amino acid transport and transmembrane transport. Predicted to act upstream of or within with a negative effect on thyroid hormone generation and thyroid-stimulating hormone secretion. Predicted to act upstream of or within thyroid hormone transport. Predicted to be located in basolateral plasma membrane; cell junction; and intracellular membrane-bounded organelle. Predicted to be integral component of membrane. Orthologous to human SLC16A10 (solute carrier family 16 member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 100.9), Kidney (RPKM 85.3) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc16a10 in Genome Data Viewer
Location:
20q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (45014229..45122392, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (43454819..43567839, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (45138433..45260155, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene Na+ dependent glucose transporter 1 Neighboring gene major facilitator superfamily domain containing 4B2 like 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108349085 Neighboring gene small nucleolar RNA, H/ACA box 69 Neighboring gene ribosome production factor 2 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. Kim DK, et al. J Biol Chem, 2001 May 18. PMID 11278508
  2. Tissue-based metabolomics reveals metabolic biomarkers and potential therapeutic targets for esophageal squamous cell carcinoma. Chen Z, et al. J Pharm Biomed Anal, 2021 Apr 15. PMID 33609949
  3. Tissue-specific alterations in thyroid hormone homeostasis in combined Mct10 and Mct8 deficiency. Müller J, et al. Endocrinology, 2014 Jan. PMID 24248460
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-phenylalanine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-phenylalanine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-tryptophan transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-tryptophan transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-tyrosine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-tyrosine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables aromatic amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aromatic amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thyroid hormone transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables thyroid hormone transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in aromatic amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in aromatic amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monocarboxylic acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylalanine transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within_negative_effect thyroid hormone generation ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within thyroid hormone transport ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone transport ISO
Inferred from Sequence Orthology
more info
  
involved_in thyroid hormone transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within_negative_effect thyroid-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan transport IEA
Inferred from Electronic Annotation
more info
  
involved_in tyrosine transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 10
Names
MCT 10
T-type amino acid transporter 1
aromatic amino acid transporter 1
solute carrier family 16 (aromatic amino acid transporter), member 10
solute carrier family 16 (monocarboxylic acid transporters), member 10
solute carrier family 16, member 10 (aromatic amino acid transporter)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138831.1 → NP_620186.1  monocarboxylate transporter 10

    See identical proteins and their annotated locations for NP_620186.1

    Status: PROVISIONAL

    Source sequence(s)
    AB047324
    UniProtKB/Swiss-Prot
    G3V621, Q91Y77
    Related
    ENSRNOP00000000718.4, ENSRNOT00000000718.6
    Conserved Domains (2) summary
    cd06174
    Location:70 → 469
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:60 → 481
    2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    45014229..45122392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039098394.2 → XP_038954322.1  monocarboxylate transporter 10 isoform X1

    UniProtKB/Swiss-Prot
    G3V621, Q91Y77
    UniProtKB/TrEMBL
    A0A0G2KAT0
    Related
    ENSRNOP00000075512.2
    Conserved Domains (2) summary
    NF033930
    Location:3 → 64
    pneumo_PspA; pneumococcal surface protein A
    cl28910
    Location:69 → 421
    MFS; Major Facilitator Superfamily

  2. XM_039098395.2 → XP_038954323.1  monocarboxylate transporter 10 isoform X2

    Conserved Domains (1) summary
    cl28910
    Location:1 → 349
    MFS; Major Facilitator Superfamily

  3. XM_063278943.1 → XP_063135013.1  monocarboxylate transporter 10 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91Y77.2 GenPept UniProtKB/Swiss-Prot:Q91Y77

Gene LinkOut

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