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Ltc4s leukotriene C4 synthase [ Mus musculus (house mouse) ]

Gene ID: 17001, updated on 20-Mar-2024

Summary

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Official Symbol
Ltc4sprovided by MGI
Official Full Name
leukotriene C4 synthaseprovided by MGI
Primary source
MGI:MGI:107498
See related
Ensembl:ENSMUSG00000020377 AllianceGenome:MGI:107498
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
The protein encoded by this gene is an enzyme that catalyzes the synthesis of leukotriene C4 by combining leukotriene A4 with reduced glutathione. The encoded protein is found in the outer nuclear membrane and in the peripheral endoplasmic reticulum. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as bronchial asthma in humans. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 93.5), mammary gland adult (RPKM 76.1) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B1.3; 11 30.4 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50127288..50129378, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50236461..50238532, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29391 Neighboring gene predicted gene, 36556 Neighboring gene mannoside acetylglucosaminyltransferase 4, isoenzyme B Neighboring gene microRNA 6919 Neighboring gene STARR-seq mESC enhancer starr_29394 Neighboring gene mastermind like transcriptional coactivator 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:50105936-50106045 Neighboring gene STARR-seq mESC enhancer starr_29397 Neighboring gene calnexin Neighboring gene STARR-seq mESC enhancer starr_29398 Neighboring gene STARR-positive B cell enhancer ABC_E1417

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structure and inhibition of mouse leukotriene C4 synthase. Niegowski D, et al. PLoS One, 2014. PMID 24810165, Free PMC Article
  2. Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation. Kim DC, et al. J Immunol, 2006 Apr 1. PMID 16547282
  3. Highly selective localization of leukotriene C4 synthase in hypothalamic and extrahypothalamic vasopressin systems of mouse brain. Shimada A, et al. Neuroscience, 2005. PMID 15730873
  4. Expression of leukotriene C4 synthase mRNA by the choroid plexus in mouse brain suggests novel neurohormone functions of cysteinyl leukotrienes. Söderström M, et al. Biochem Biophys Res Commun, 2003 Aug 8. PMID 12878209
  5. Formation of murine macrophage-derived 5-oxo-7-glutathionyl-8,11,14-eicosatrienoic acid (FOG7) is catalyzed by leukotriene C4 synthase. Hevko JM, et al. J Biol Chem, 2002 Mar 1. PMID 11748223

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mutational and kinetic data, together with molecular simulations, suggest that phosphorylation of Ser(36) inhibits the catalytic function of LTC4S by interference with the catalytic machinery.
    Title: Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity.
  2. LTC4 synthase was selectively localized in the vasopressinergic magnocellular neurons of the hypothalamic paraventricular, supraoptic and suprachiasmatic nuclei and in the retrochiasmatic area.
    Title: Highly selective localization of leukotriene C4 synthase in hypothalamic and extrahypothalamic vasopressin systems of mouse brain.
  3. These results suggest that LTC(4) synthase, thought to be specific for the conjugation of GSH to LTA(4), can also recognize 5-oxoETE as an electrophilic substrate.
    Title: Formation of murine macrophage-derived 5-oxo-7-glutathionyl-8,11,14-eicosatrienoic acid (FOG7) is catalyzed by leukotriene C4 synthase.
  4. Expression of leukotriene C4 synthase mRNA in the choroid plexus.
    Title: Expression of leukotriene C4 synthase mRNA by the choroid plexus in mouse brain suggests novel neurohormone functions of cysteinyl leukotrienes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables leukotriene-C4 synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables leukotriene-C4 synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables leukotriene-C4 synthase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables lipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in leukotriene biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leukotriene biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within leukotriene metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within leukotriene metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in leukotriene metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leukotriene C4 synthase
Names
LTC4 synthase
glutathione S-transferase LTC4
leukotriene-C(4) synthase
NP_001300897.1
NP_032547.1
XP_036012258.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313968.2 → NP_001300897.1  leukotriene C4 synthase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL627187
    Consensus CDS
    CCDS83799.1
    UniProtKB/TrEMBL
    Q8K355
    Related
    ENSMUSP00000098823.3, ENSMUST00000101265.9
    Conserved Domains (1) summary
    pfam01124
    Location:8 → 105
    MAPEG; MAPEG family

  2. NM_008521.3 → NP_032547.1  leukotriene C4 synthase isoform 1

    See identical proteins and their annotated locations for NP_032547.1

    Status: REVIEWED

    Source sequence(s)
    AL627187
    Consensus CDS
    CCDS24631.1
    UniProtKB/Swiss-Prot
    Q5SVR7, Q60860, Q9QVS1
    Related
    ENSMUSP00000099833.4, ENSMUST00000102772.4
    Conserved Domains (1) summary
    pfam01124
    Location:8 → 124
    MAPEG; MAPEG family

RNA

  1. NR_132732.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL627187
    Related
    ENSMUST00000125555.2

  2. NR_132733.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL627187
    Related
    ENSMUST00000221525.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    50127288..50129378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156365.1 → XP_036012258.1  leukotriene C4 synthase isoform X1

    Conserved Domains (1) summary
    pfam01124
    Location:45 → 126
    MAPEG; MAPEG family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60860.1 GenPept UniProtKB/Swiss-Prot:Q60860

Gene LinkOut

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