Lep leptin [ Mus musculus (house mouse) ]

Gene ID: 16846, updated on 22-Apr-2024

Summary

Official Symbol: Lepprovided by MGI
Official Full Name: leptinprovided by MGI
Primary source: MGI:MGI:104663
See related: Ensembl:ENSMUSG00000059201 AllianceGenome:MGI:104663
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ob; obese
Summary: Enables DNA binding activity and growth factor activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Acts upstream of or within several processes, including insulin secretion; monocarboxylic acid metabolic process; and regulation of insulin secretion. Located in cytoplasm and extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; early conceptus; and genitourinary system. Used to study abdominal obesity-metabolic syndrome (multiple); fatty liver disease (multiple); obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 267.7), genital fat pad adult (RPKM 183.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 6 A3.3; 6 12.3 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (29060220..29073875)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (29060221..29073876)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Leptin signalling regulates transcriptional differences in granulosa cells from genetically obese mice but not the activation of NLRP3 inflammasome.
Title: Leptin signalling regulates transcriptional differences in granulosa cells from genetically obese mice but not the activation of NLRP3 inflammasome.
A negative feedback loop between TET2 and leptin in adipocyte regulates body weight.
Title: A negative feedback loop between TET2 and leptin in adipocyte regulates body weight.
Influence of leptin and its receptors on individuals under chronic social stress behavior.
Title: Influence of leptin and its receptors on individuals under chronic social stress behavior.
AMP-activated protein kinase activation suppresses leptin expression independently of adipogenesis in primary murine adipocytes.
Title: AMP-activated protein kinase activation suppresses leptin expression independently of adipogenesis in primary murine adipocytes.
Leptin haploinsufficiency exerts sex-dependent partial protection in SOD1[G93A] mice by reducing inflammatory pathways in the adipose tissue.
Title: Leptin haploinsufficiency exerts sex-dependent partial protection in SOD1(G93A) mice by reducing inflammatory pathways in the adipose tissue.
The potential of leptin to alleviate chronic heart failure through miR-27a/b-3p: A preclinical study.
Title: The potential of leptin to alleviate chronic heart failure through miR-27a/b-3p: A preclinical study.
Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease.
Title: Leptin antagonism attenuates hypertension and renal injury in an experimental model of autoimmune disease.
Leptin secreted by adipocytes promotes EMT transition and endometrial cancer progression via the JAK2/STAT3 signalling pathway.
Title: Leptin secreted by adipocytes promotes EMT transition and endometrial cancer progression via the JAK2/STAT3 signalling pathway.
Hypothalamic FTO promotes high-fat diet-induced leptin resistance in mice through increasing CX3CL1 expression.
Title: Hypothalamic FTO promotes high-fat diet-induced leptin resistance in mice through increasing CX3CL1 expression.
Impact of leptin deficiency on male tibia and vertebral body 3D bone architecture independent of changes in body weight.
Title: Impact of leptin deficiency on male tibia and vertebral body 3D bone architecture independent of changes in body weight.

Submit: New GeneRIF Correction See all GeneRIFs (597)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (2) 1 citation
Targeted (6) 1 citation
Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC316374P2 (e-PCR)
- UniSTS:272963

PMC23608P1 (e-PCR)
- UniSTS:272206

PMC187774P1 (e-PCR)
- UniSTS:271732

PMC21729P1 (e-PCR)
- UniSTS:143768

Lep (e-PCR), detects polymorphism
- UniSTS:143768

Lep (e-PCR), detects polymorphism
- UniSTS:143769

Lep (e-PCR), detects polymorphism
- UniSTS:143770

Lep (e-PCR), detects polymorphism
- UniSTS:143771

Lep (e-PCR), detects polymorphism
- UniSTS:143772

LEP-3 (e-PCR)
- UniSTS:253879

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IDA Inferred from Direct Assay more info
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables leptin receptor binding	ISO Inferred from Sequence Orthology more info
enables peptide hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of protein kinase C activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of protein kinase C activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adipose tissue development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in adult feeding behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aorta development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bile acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in bone growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone mineralization involved in bone maturation	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to insulin stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to leptin stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cholesterol metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within eating behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within elastin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in energy reserve metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in energy reserve metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid beta-oxidation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fatty acid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hormone metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within insulin secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intestinal absorption	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in leptin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in leptin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of appetite	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of appetite by leptin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of appetite by leptin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cartilage development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glucagon secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glucose import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glutamine transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in ovulation from ovarian follicle	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in placenta development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of developmental growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hepatic stellate cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monoatomic ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of myeloid cell differentiation	IDA Inferred from Direct Assay more info
involved_in positive regulation of p38MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of catalytic activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of intestinal cholesterol absorption	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of lipid biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of lipoprotein lipid oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in regulation of natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of nitric-oxide synthase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of steroid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to dietary excess	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to dietary excess	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to dietary excess	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to insulin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sexual reproduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sexual reproduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in tyrosine phosphorylation of STAT protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leptin

Names: obesity factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.