Lcat lecithin cholesterol acyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lcatprovided by MGI
Official Full Name: lecithin cholesterol acyltransferaseprovided by MGI
Primary source: MGI:MGI:96755
See related: Ensembl:ENSMUSG00000035237 AllianceGenome:MGI:96755
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D8Wsu61e
Summary: Enables phosphatidylcholine-sterol O-acyltransferase activity and platelet-activating factor acetyltransferase activity. Involved in regulation of high-density lipoprotein particle assembly. Acts upstream of or within cholesterol metabolic process and lipoprotein biosynthetic process. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and integumental system. Used to study Norum disease. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to human LCAT (lecithin-cholesterol acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 395.2), liver E18 (RPKM 118.1) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.06 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106666183..106670034, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (105939551..105943402, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High density lipoproteins mediate in vivo protection against staphylococcal phenol-soluble modulins.
Title: High density lipoproteins mediate in vivo protection against staphylococcal phenol-soluble modulins.
Apolipoprotein A-I in mouse cerebrospinal fluid derives from the liver and intestine via plasma high-density lipoproteins assembled by ABCA1 and LCAT.
Title: Apolipoprotein A-I in mouse cerebrospinal fluid derives from the liver and intestine via plasma high-density lipoproteins assembled by ABCA1 and LCAT.
Esterification of side-chain oxysterols by lysosomal phospholipase A2.
Title: Esterification of side-chain oxysterols by lysosomal phospholipase A2.
It has been reported that universal deletion of Apoa1 or Lcat expression in mice fed western-type diet results in increased sensitivity to body-weight gain compared to control C57BL/6 group.
Title: Impact of apolipoprotein A1- or lecithin:cholesterol acyltransferase-deficiency on white adipose tissue metabolic activity and glucose homeostasis in mice.
metabolic phenotypes in lecithin cholesterol acyltyransferase-deficient mice
Title: Novel metabolic phenotypes in lecithin cholesterol acyltyransferase-deficient mice.
Taken together, these results suggest that apoE-containing discoidal HDLs do not require LCAT-dependent maturation to mediate efficient Abeta clearance
Title: LCAT deficiency does not impair amyloid metabolism in APP/PS1 mice.
increased cholesterol esterification by LCAT is atheroprotective
Title: Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice.
Gene transfer of WT LCAT in LCAT(-/-) mice increased 11.8-fold the plasma cholesterol, whereas the LCAT[T147I] and LCAT[P274S] mutants caused a 5.2- and 2.9-fold increase, respectively.
Title: The Effect of Natural LCAT Mutations on the Biogenesis of HDL.
DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels.
Title: DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels.
adrenal glucocorticoid function in LCAT knockout (KO) mice
Title: LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

AW546649 (e-PCR)
- UniSTS:179806

AI046659 (e-PCR)
- UniSTS:179807

Lcat (e-PCR), detects polymorphism
- UniSTS:507015

RH125919 (e-PCR)
- UniSTS:142734

RH124920 (e-PCR)
- UniSTS:161742

NoName (e-PCR)
- UniSTS:235997

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	ISO Inferred from Sequence Orthology more info
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables apolipoprotein A-I binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine-sterol O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine-sterol O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylcholine-sterol O-acyltransferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables platelet-activating factor acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables platelet-activating factor acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables sterol esterase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cholesterol metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipoprotein biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipoprotein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of high-density lipoprotein particle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in response to copper ion	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	ISO Inferred from Sequence Orthology more info
involved_in reverse cholesterol transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within steroid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in very-low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info	PubMed
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylcholine-sterol acyltransferase

Names: 1-alkyl-2-acetylglycerophosphocholine esterase; PAF acetylhydrolase; lecithin-cholesterol acyltransferase Lcat; phospholipid-cholesterol acyltransferase; platelet-activating factor acetylhydrolase

NP_032516.2

EC 2.3.1.43

EC 3.1.1.47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.