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Lama5 laminin, alpha 5 [ Mus musculus (house mouse) ]

Gene ID: 16776, updated on 31-Mar-2024

Summary

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Official Symbol
Lama5provided by MGI
Official Full Name
laminin, alpha 5provided by MGI
Primary source
MGI:MGI:105382
See related
Ensembl:ENSMUSG00000015647 AllianceGenome:MGI:105382
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
[a]5; mKIAA0533; laminin-511
Summary
Enables integrin binding activity. Acts upstream of or within several processes, including animal organ development; morphogenesis of an epithelium; and protein localization to plasma membrane. Located in basement membrane and neuromuscular junction. Part of laminin-10 complex. Is active in synaptic cleft. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; respiratory system; and sensory organ. Used to study cystic kidney disease. Orthologous to human LAMA5 (laminin subunit alpha 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 40.7), mammary gland adult (RPKM 30.3) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Lama5 in Genome Data Viewer
Location:
2 H4; 2 102.7 cM
Exon count:
79
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179818166..179867652, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180176373..180225904, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 2 Neighboring gene predicted gene, 29886 Neighboring gene STARR-positive B cell enhancer mm9_chr2:179905789-179906089 Neighboring gene adhesion regulating molecule 1 26S proteasome ubiquitin receptor Neighboring gene microRNA 7005 Neighboring gene STARR-seq mESC enhancer starr_06728 Neighboring gene STARR-seq mESC enhancer starr_06729 Neighboring gene STARR-positive B cell enhancer ABC_E6036 Neighboring gene microRNA 3091 Neighboring gene CDK5 and Abl enzyme substrate 2 Neighboring gene STARR-positive B cell enhancer ABC_E333 Neighboring gene ribosomal protein S21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Intra-vessel heterogeneity establishes enhanced sites of macromolecular leakage downstream of laminin α5. Richards M, et al. Cell Rep, 2021 Jun 22. PMID 34161758
  2. Canonical Wnt signaling regulates branching morphogenesis of submandibular gland by modulating levels of lama5. Gou L, et al. Int J Dev Biol, 2021. PMID 33629734
  3. Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke. Nirwane A, et al. Acta Neuropathol Commun, 2019 Feb 18. PMID 30777135, Free PMC Article
  4. Loss of Endothelial Laminin α5 Exacerbates Hemorrhagic Brain Injury. Gautam J, et al. Transl Stroke Res, 2019 Dec. PMID 30693425, Free PMC Article
  5. Fractone Bulbs Derive from Ependymal Cells and Their Laminin Composition Influence the Stem Cell Niche in the Subventricular Zone. Nascimento MA, et al. J Neurosci, 2018 Apr 18. PMID 29530987, Free PMC Article

See all (221) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A dispensable role of oligodendrocyte-derived laminin-alpha5 in brain homeostasis and intracerebral hemorrhage.
    Title: A dispensable role of oligodendrocyte-derived laminin-α5 in brain homeostasis and intracerebral hemorrhage.
  2. Endothelial and mural laminin-alpha5 contributes to neurovascular integrity maintenance.
    Title: Endothelial and mural laminin-α5 contributes to neurovascular integrity maintenance.
  3. A heterozygous LAMA5 variant may contribute to slowly progressive, vinculin-enhanced familial FSGS and pulmonary defects.
    Title: A heterozygous LAMA5 variant may contribute to slowly progressive, vinculin-enhanced familial FSGS and pulmonary defects.
  4. Laminin-511 and recombinant vitronectin supplementation enables human pluripotent stem cell culture and differentiation on conventional tissue culture polystyrene surfaces in xeno-free conditions.
    Title: Laminin-511 and recombinant vitronectin supplementation enables human pluripotent stem cell culture and differentiation on conventional tissue culture polystyrene surfaces in xeno-free conditions.
  5. Canonical Wnt signaling regulates branching morphogenesis of submandibular gland by modulating levels of lama5.
    Title: Canonical Wnt signaling regulates branching morphogenesis of submandibular gland by modulating levels of lama5.
  6. Intra-vessel heterogeneity establishes enhanced sites of macromolecular leakage downstream of laminin alpha5.
    Title: Intra-vessel heterogeneity establishes enhanced sites of macromolecular leakage downstream of laminin α5.
  7. Regulation and Function of Laminin A5 during Mouse and Human Decidualization.
    Title: Regulation and Function of Laminin A5 during Mouse and Human Decidualization.
  8. Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation and Wnt4-mediated epithelial crosstalk.
    Title: Laminin alpha 5 regulates mammary gland remodeling through luminal cell differentiation and Wnt4-mediated epithelial crosstalk.
  9. The lymph node stromal laminin alpha5 shapes alloimmunity.
    Title: The lymph node stromal laminin α5 shapes alloimmunity.
  10. Laminin alpha2, alpha4, and alpha5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precursor Cells.
    Title: Laminin α2, α4, and α5 Chains Positively Regulate Migration and Survival of Oligodendrocyte Precursor Cells.
Submit: New GeneRIF Correction See all GeneRIFs (51)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent IBA
Inferred from Biological aspect of Ancestor
more info
  
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables integrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within branching involved in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hair follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within morphogenesis of a polarized epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within morphogenesis of embryonic epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within muscle organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in postsynapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within trunk neural crest cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
  
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular matrix of synaptic cleft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular matrix of synaptic cleft IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in extracellular matrix of synaptic cleft IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of laminin-10 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of laminin-10 complex ISO
Inferred from Sequence Orthology
more info
  
part_of laminin-5 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic cleft IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
laminin subunit alpha-5
Names
laminin-10 subunit alpha
laminin-11 subunit alpha
laminin-15 subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081171.2 → NP_001074640.1  laminin subunit alpha-5 precursor

    See identical proteins and their annotated locations for NP_001074640.1

    Status: VALIDATED

    Source sequence(s)
    AI853660, AJ293593, AK158204, AL663027, CJ124774, CK021961, CN702366, DV646114
    Consensus CDS
    CCDS38375.1
    UniProtKB/Swiss-Prot
    A2ABW7, Q61001, Q9JHQ6
    Related
    ENSMUSP00000015791.6, ENSMUST00000015791.6
    Conserved Domains (10) summary
    smart00180
    Location:2025 → 2069
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00281
    Location:1690 → 1819
    LamB; Laminin B domain
    smart00282
    Location:3542 → 3669
    LamG; Laminin G domain
    cd00055
    Location:682 → 724
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3337 → 3495
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00053
    Location:1443 → 1491
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:59 → 303
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam06008
    Location:2190 → 2452
    Laminin_I; Laminin Domain I
    pfam06009
    Location:2642 → 2764
    Laminin_II; Laminin Domain II
    cl02193
    Location:2230 → 2316
    VirB5_like; VirB5 protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    179818166..179867652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61001.4 GenPept UniProtKB/Swiss-Prot:Q61001

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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