Krt8 keratin 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt8provided by MGI
Official Full Name: keratin 8provided by MGI
Primary source: MGI:MGI:96705
See related: Ensembl:ENSMUSG00000049382 AllianceGenome:MGI:96705
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K8; Card2; EndoA; Krt2-8; Krt-2.8
Summary: Predicted to enable scaffold protein binding activity. Acts upstream of or within several processes, including cell differentiation involved in embryonic placenta development; cell surface receptor signaling pathway; and hepatocyte apoptotic process. Located in several cellular components, including Z disc; apicolateral plasma membrane; and sarcolemma. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to human KRT8 (keratin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 1701.0), large intestine adult (RPKM 1411.0) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F2; 15 57.2 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (101905146..101912777, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (101996711..102004342, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TEAD4 regulates KRT8 and YAP in preimplantation embryos in mice but not in cattle.
Title: TEAD4 regulates KRT8 and YAP in preimplantation embryos in mice but not in cattle.
Defining a timeline of colon pathologies after keratin 8 loss: rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliation.
Title: Defining a timeline of colon pathologies after keratin 8 loss: rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliation.
Keratin8 Deficiency Aggravates Retinal Ganglion Cell Damage Under Acute Ocular Hypertension.
Title: Keratin8 Deficiency Aggravates Retinal Ganglion Cell Damage Under Acute Ocular Hypertension.
Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration.
Title: Phosphorylation of KRT8 (keratin 8) by excessive mechanical load-activated PKN (protein kinase N) impairs autophagosome initiation and contributes to disc degeneration.
Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon.
Title: Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon.
Generation of a tissue-specific transgenic model for K8 phosphomutants: A tool to investigate the role of K8 phosphorylation during skin carcinogenesis in vivo.
Title: Generation of a tissue-specific transgenic model for K8 phosphomutants: A tool to investigate the role of K8 phosphorylation during skin carcinogenesis in vivo.
Keratin 8 mutations in transgenic mice predispose to lung injury.
Title: Keratin 8 mutations in transgenic mice predispose to lung injury.
Keratin 8/18 Regulate the Akt Signaling Pathway.
Title: Keratin 8/18 Regulate the Akt Signaling Pathway.
SOX10-Cre-Labeled Cells Under the Tongue Epithelium Serve as Progenitors for Taste Bud Cells That Are Mainly Type III and Keratin 8-Low.
Title: SOX10-Cre-Labeled Cells Under the Tongue Epithelium Serve as Progenitors for Taste Bud Cells That Are Mainly Type III and Keratin 8-Low.
This study demonstrated that partial K8 deficiency reduces beta-cell stress tolerance and aggravates diabetes development in response to streptozotocin, while there is no major susceptibility to a high fat diet.
Title: Decreased levels of keratin 8 sensitize mice to streptozotocin-induced diabetes.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA960620 (e-PCR)
- UniSTS:160514

Krt8 (e-PCR), detects polymorphism
- UniSTS:502649

Krt1c (e-PCR), detects polymorphism
- UniSTS:143745

Krt2-8 (e-PCR), detects polymorphism
- UniSTS:143746

RH136318 (e-PCR)
- UniSTS:210309

Krt8 (e-PCR), detects polymorphism
- UniSTS:499095

RH125425 (e-PCR)
- UniSTS:162247

Krt8 (e-PCR), detects polymorphism
- UniSTS:499181

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation involved in embryonic placenta development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hepatocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hydrostatic pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to other organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in costamere	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of dystrophin-associated glycoprotein complex	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	IDA Inferred from Direct Assay more info	PubMed
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in keratin filament	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: keratin, type II cytoskeletal 8

Names: CK-8; cytokeratin endo A; cytokeratin-8; keratin complex 2, basic, gene 8; type-II keratin Kb8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031170.2 → NP_112447.2 keratin, type II cytoskeletal 8

See identical proteins and their annotated locations for NP_112447.2

Status: VALIDATED

Source sequence(s)

AK145777

Consensus CDS

CCDS27868.1

UniProtKB/Swiss-Prot

P11679, Q3KQK5, Q3TGI1, Q3TJE1, Q3TKY7, Q61463, Q61518, Q61519

Related

ENSMUSP00000023952.9, ENSMUST00000023952.10

Conserved Domains (3) summary

pfam00038
Location:96 → 407

Filament; Intermediate filament protein

pfam16208
Location:69 → 93

Keratin_2_head; Keratin type II head

cl24005
Location:288 → 347

DUF2570; Protein of unknown function (DUF2570)