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Krt17 keratin 17 [ Mus musculus (house mouse) ]

Gene ID: 16667, updated on 4-May-2024

Summary

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Official Symbol
Krt17provided by MGI
Official Full Name
keratin 17provided by MGI
Primary source
MGI:MGI:96691
See related
Ensembl:ENSMUSG00000035557 AllianceGenome:MGI:96691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K17; Krt1-17
Summary
The protein encoded by this gene is a member of the type I keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The encoded protein is a cytokeratin required for the normal growth of hair follicles and may act in psoriasis as an immunopathogenic autoantigen. [provided by RefSeq, Sep 2015]
Expression
Biased expression in thymus adult (RPKM 78.2), mammary gland adult (RPKM 14.4) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 63.44 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100147041..100151855, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100256215..100261029, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transcription elongation factor B (SIII), polypeptide 2 pseudogene Neighboring gene keratin 16 Neighboring gene keratin 42 Neighboring gene STARR-seq mESC enhancer starr_30718 Neighboring gene predicted gene 14206

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion and Resistance to Immune-Checkpoint Blockade. Wang W, et al. Clin Cancer Res, 2022 Jul 1. PMID 35621713, Free PMC Article
  2. Keratin 17 Promotes T Cell Response in Allergic Contact Dermatitis by Upregulating C-C Motif Chemokine Ligand 20. Luo Y, et al. Front Immunol, 2022. PMID 35178048, Free PMC Article
  3. Keratin 17 regulates nuclear morphology and chromatin organization. Jacob JT, et al. J Cell Sci, 2020 Oct 30. PMID 33008845, Free PMC Article
  4. Stress keratin 17 enhances papillomavirus infection-induced disease by downregulating T cell recruitment. Wang W, et al. PLoS Pathog, 2020 Jan. PMID 31968015, Free PMC Article
  5. p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis. Liao C, et al. J Invest Dermatol, 2016 Mar. PMID 26747697

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation-Induced Skin Damage.
    Title: Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation-Induced Skin Damage.
  2. Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion and Resistance to Immune-Checkpoint Blockade.
    Title: Stress Keratin 17 Expression in Head and Neck Cancer Contributes to Immune Evasion and Resistance to Immune-Checkpoint Blockade.
  3. A role for keratin 17 during DNA damage response and tumor initiation.
    Title: A role for keratin 17 during DNA damage response and tumor initiation.
  4. K17 was critical for preventing T cell infiltration in MmuPV1-induced papillomas by inhibiting the CXCL9/CXCL10/CXCR3 axis
    Title: Stress keratin 17 enhances papillomavirus infection-induced disease by downregulating T cell recruitment.
  5. Narrow-band ultraviolet B irradiation with doses of MED or higher could eliminate the imiquimod-induced psoriasis-like dermatitis and inhibit K17 expression via the ERK1/2 and STAT3 signaling pathways.
    Title: NB-UVB irradiation downregulates keratin-17 expression in keratinocytes by inhibiting the ERK1/2 and STAT3 signaling pathways.
  6. TGF-beta1-induced CK17 enhances cancer stem cell-like properties rather than epithelial-mesenchymal transition in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway.
    Title: TGF-β1-induced CK17 enhances cancer stem cell-like properties rather than EMT in promoting cervical cancer metastasis via the ERK1/2-MZF1 signaling pathway.
  7. the data suggest that the loss of Krt17 may foster an overall protective environment for lesion-prone cervical tissue.
    Title: Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo.
  8. High KR17 expression is associated with oral cancer.
    Title: Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth.
  9. p53 operates as a direct Krt17 repressor that invites therapeutic targeting in radiodermatitis .
    Title: p53 Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model of Radiation Dermatitis.
  10. genetic loss of caspase-7 promotes solar-simulated light-induced skin carcinogenesis by blocking caspase-7-mediated cleavage of keratin-17.
    Title: Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intermediate filament organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within keratinization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within morphogenesis of an epithelium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hair follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cornified envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
keratin, type I cytoskeletal 17
Names
CK-17
cytokeratin-17
keratin complex 1, acidic, gene 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010663.3 → NP_034793.1  keratin, type I cytoskeletal 17

    See identical proteins and their annotated locations for NP_034793.1

    Status: REVIEWED

    Source sequence(s)
    AL590873, BC132454, EH104192, EH105154
    Consensus CDS
    CCDS25415.1
    UniProtKB/Swiss-Prot
    A2A4G6, Q61783, Q9QWL7
    Related
    ENSMUSP00000079699.7, ENSMUST00000080893.7
    Conserved Domains (1) summary
    pfam00038
    Location:84 → 394
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100147041..100151855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245607.1 → XP_030101467.1  keratin, type I cytoskeletal 17 isoform X1

    Conserved Domains (1) summary
    pfam00038
    Location:25 → 312
    Filament; Intermediate filament protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QWL7.3 GenPept UniProtKB/Swiss-Prot:Q9QWL7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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