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Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 [ Mus musculus (house mouse) ]

Gene ID: 16522, updated on 21-Apr-2024

Summary

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Official Symbol
Kcnj6provided by MGI
Official Full Name
potassium inwardly-rectifying channel, subfamily J, member 6provided by MGI
Primary source
MGI:MGI:104781
See related
Ensembl:ENSMUSG00000043301 AllianceGenome:MGI:104781
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
wv; BIR1; GIRK2; KATP2; KCNJ7; Kir3.2; weaver
Summary
Enables G-protein activated inward rectifier potassium channel activity. Acts upstream of or within thyroid hormone metabolic process. Located in parallel fiber to Purkinje cell synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and skeleton. Human ortholog(s) of this gene implicated in alcohol use disorder and heroin dependence. Orthologous to human KCNJ6 (potassium inwardly rectifying channel subfamily J member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 1.9), testis adult (RPKM 1.8) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C4; 16 55.44 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (94545839..94798719, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (94744980..94997696, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41504 Neighboring gene predicted gene, 41505 Neighboring gene predicted gene, 41507 Neighboring gene STARR-seq mESC enhancer starr_41586 Neighboring gene STARR-seq mESC enhancer starr_41589 Neighboring gene STARR-seq mESC enhancer starr_41593 Neighboring gene STARR-seq mESC enhancer starr_41595 Neighboring gene predicted gene, 31407 Neighboring gene STARR-seq mESC enhancer starr_41597 Neighboring gene STARR-seq mESC enhancer starr_41598 Neighboring gene 60S ribosomal protein L7a pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K(+) channel. Chen IS, et al. J Physiol, 2022 Feb. PMID 34881429
  2. The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer's Disease. Alfaro-Ruiz R, et al. Int J Mol Sci, 2021 Oct 14. PMID 34681766, Free PMC Article
  3. Beta-Cell Ion Channels and Their Role in Regulating Insulin Secretion. Thompson B, et al. Compr Physiol, 2021 Oct 12. PMID 34636409, Free PMC Article
  4. Insight into the Selectivity of Kir3.2 toward Phosphatidylinositides. Qiao P, et al. Biochemistry, 2020 Jun 9. PMID 32372643
  5. Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel. Liu Y, et al. Nat Commun, 2019 Mar 22. PMID 30902995, Free PMC Article

See all (332) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GIRK2 potassium channels expressed by the AgRP neurons decrease adiposity and body weight in mice.
    Title: GIRK2 potassium channels expressed by the AgRP neurons decrease adiposity and body weight in mice.
  2. A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K(+) channel.
    Title: A novel ion conducting route besides the central pore in an inherited mutant of G-protein-gated inwardly rectifying K(+) channel.
  3. The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer's Disease.
    Title: The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer's Disease.
  4. Insight into the Selectivity of Kir3.2 toward Phosphatidylinositides.
    Title: Insight into the Selectivity of Kir3.2 toward Phosphatidylinositides.
  5. These results reveal selective small molecule binding and uncover a mechanism by which rotation of the cytoplasmic domain can modulate GIRK*phosphatidylinositide interactions.
    Title: Selective binding of a toxin and phosphatidylinositides to a mammalian potassium channel.
  6. The results of this study indicated that Kcnj6 triploid mice show an increase in GIRK2 protein levels compared to WT mice in the cortex and thalamus.
    Title: Kcnj6(GIRK2) trisomy is not sufficient for conferring the susceptibility to infantile spasms seen in the Ts65Dn mouse model of down syndrome.
  7. GIRK2 isoform balance within a neuron can impact the processing of afferent inhibitory input and associated behavior.
    Title: GIRK2 splice variants and neuronal G protein-gated K(+) channels: implications for channel function and behavior.
  8. Locomotor activity of the mice was not changed compared to that of GIRK2(floxed) mice, when tested in the open field
    Title: Deletion of GIRK2 subunit containing GIRK channels of neurons expressing dopamine transporter decrease immobility time on forced swimming in mice.
  9. Results indicate that the properties and inhibitory activity of dorsal raphe neurons are highly regulated by G protein-coupled inwardly rectifying K+ (GIRK) 2 subunit-containing channels, introducing GIRK channels as potential candidates for studying the pathophysiology and treatment of affective disorders.
    Title: Inactivation of GIRK channels weakens the pre- and postsynaptic inhibitory activity in dorsal raphe neurons.
  10. Increased Kcnj6 gene dose is necessary for synaptic and cognitive dysfunction in the animal model of Down Syndrome.
    Title: Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.
Submit: New GeneRIF Correction See all GeneRIFs (47)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein activated inward rectifier potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of insulin secretion TAS
Traceable Author Statement
more info
 PubMed 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of monoatomic ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of presynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thyroid hormone metabolic process IMP
Inferred from Mutant Phenotype
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
G protein-activated inward rectifier potassium channel 2
Names
G-protein-coupled inward rectifier K+ channel 2-1
G-protein-coupled inward rectifier K+ channel 2-A
G-protein-coupled inward rectifier K+ channel 2-B
G-protein-coupled inward rectifier K+ channel 2-C
GIRK-2
inward rectifier K(+) channel Kir3.2
potassium channel, inwardly rectifying subfamily J member 6
potassium inwardly-rectifying channel J6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025584.2 → NP_001020755.1  G protein-activated inward rectifier potassium channel 2 isoform Girk2-1

    See identical proteins and their annotated locations for NP_001020755.1

    Status: VALIDATED

    Source sequence(s)
    AK081109, BB591362
    Consensus CDS
    CCDS37408.1
    UniProtKB/TrEMBL
    Q3UTV4, Q8C4T8
    Related
    ENSMUSP00000093558.5, ENSMUST00000095873.12
    Conserved Domains (2) summary
    pfam01007
    Location:59 → 198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205 → 374
    IRK_C; Inward rectifier potassium channel C-terminal domain

  2. NM_001025585.2 → NP_001020756.1  G protein-activated inward rectifier potassium channel 2 isoform Girk2B

    See identical proteins and their annotated locations for NP_001020756.1

    Status: VALIDATED

    Source sequence(s)
    BB277039, BB591362, D86040
    UniProtKB/TrEMBL
    Q8C8Y6
    Related
    ENSMUST00000232403.2
    Conserved Domains (1) summary
    cl21560
    Location:59 → 318
    Ion_trans_2; Ion channel

  3. NM_001025590.2 → NP_001020761.1  G protein-activated inward rectifier potassium channel 2 isoform Girk2C

    See identical proteins and their annotated locations for NP_001020761.1

    Status: VALIDATED

    Source sequence(s)
    AC165248
    Consensus CDS
    CCDS49921.1
    UniProtKB/TrEMBL
    A0A0R4J239, Q8C8Y6
    Related
    ENSMUSP00000130321.2, ENSMUST00000165538.3
    Conserved Domains (1) summary
    cl21560
    Location:41 → 302
    Ion_trans_2; Ion channel

  4. NM_010606.2 → NP_034736.2  G protein-activated inward rectifier potassium channel 2 isoform Girk2A-1

    See identical proteins and their annotated locations for NP_034736.2

    Status: VALIDATED

    Source sequence(s)
    AB029502, AC165271, AK044218, BB591362
    Consensus CDS
    CCDS37409.1
    UniProtKB/TrEMBL
    Q0VB45, Q3UTV4
    Related
    ENSMUSP00000097108.3, ENSMUST00000099508.4
    Conserved Domains (2) summary
    pfam01007
    Location:59 → 198
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:205 → 374
    IRK_C; Inward rectifier potassium channel C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    94545839..94798719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246104.2 → XP_011244406.1  G protein-activated inward rectifier potassium channel 2 isoform X1

    See identical proteins and their annotated locations for XP_011244406.1

    UniProtKB/TrEMBL
    A0A338P6L0, Q3UTV4
    Related
    ENSMUSP00000156014.2, ENSMUST00000232562.2
    Conserved Domains (2) summary
    pfam01007
    Location:41 → 180
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:187 → 356
    IRK_C; Inward rectifier potassium channel C-terminal domain

RNA

  1. XR_004939169.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48542.1 GenPept UniProtKB/Swiss-Prot:P48542

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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