Itgb3 integrin beta 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgb3provided by MGI
Official Full Name: integrin beta 3provided by MGI
Primary source: MGI:MGI:96612
See related: Ensembl:ENSMUSG00000020689 AllianceGenome:MGI:96612
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD61; GP3A; INGRB3
Summary: Enables integrin binding activity and protein kinase C binding activity. Involved in several processes, including positive regulation of T cell migration; positive regulation of osteoblast proliferation; and regulation of serotonin uptake. Acts upstream of or within several processes, including cellular response to platelet-derived growth factor stimulus; positive regulation of cell-substrate adhesion; and positive regulation of fibroblast migration. Located in several cellular components, including external side of plasma membrane; focal adhesion; and glutamatergic synapse. Part of alpha9-beta1 integrin-ADAM8 complex and alphav-beta3 integrin-PKCalpha complex. Is integral component of synaptic membrane. Is expressed in several structures, including bladder; dorsal aorta; gut; liver; and lung. Used to study Glanzmann's thrombasthenia and platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (integrin subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 21.3), ovary adult (RPKM 17.5) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 67.84 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (104498826..104561302)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (104608000..104670476)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model.
Title: Upregulation of Integrin beta-3 in astrocytes upon Alzheimer's disease progression in the 5xFAD mouse model.
Role of Formyl Peptide Receptors and beta-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with alphaVbeta3-Integrin.
Title: Role of Formyl Peptide Receptors and β-Arrestin-1 in suPAR Signal Transduction in Mouse Podocytes: Interactions with αVβ3-Integrin.
CD61 identifies a superior population of aged murine HSCs and is required to preserve quiescence and self-renewal.
Title: CD61 identifies a superior population of aged murine HSCs and is required to preserve quiescence and self-renewal.
Matrix stiffness controls megakaryocyte adhesion, fibronectin fibrillogenesis, and proplatelet formation through Itgbeta3.
Title: Matrix stiffness controls megakaryocyte adhesion, fibronectin fibrillogenesis, and proplatelet formation through Itgβ3.
Milk osteopontin promotes intestinal development by up-regulating the expression of integrin alphavbeta3 and CD44.
Title: Milk osteopontin promotes intestinal development by up-regulating the expression of integrin αvβ3 and CD44.
Integrin beta3-Mediated Cell Senescence Associates with Gut Inflammation and Intestinal Degeneration in Models of Alzheimer's Disease.
Title: Integrin β3-Mediated Cell Senescence Associates with Gut Inflammation and Intestinal Degeneration in Models of Alzheimer's Disease.
Integrin beta3 Mediates Sepsis and Mechanical Ventilation-Associated Pulmonary Fibrosis Through Glycometabolic Reprogramming.
Title: Integrin β3 Mediates Sepsis and Mechanical Ventilation-Associated Pulmonary Fibrosis Through Glycometabolic Reprogramming.
SHIP1 Controls Internal Platelet Contraction and alphaIIbbeta3 Integrin Dynamics in Early Platelet Activation.
Title: SHIP1 Controls Internal Platelet Contraction and α(IIb)β(3) Integrin Dynamics in Early Platelet Activation.
Integrin beta3 in forebrain Emx1-expressing cells regulates repetitive self-grooming and sociability in mice.
Title: Integrin β3 in forebrain Emx1-expressing cells regulates repetitive self-grooming and sociability in mice.
alphaVbeta3 Integrin Expression Is Essential for Replication of Mosquito and Tick-Borne Flaviviruses in Murine Fibroblast Cells.
Title: αVβ3 Integrin Expression Is Essential for Replication of Mosquito and Tick-Borne Flaviviruses in Murine Fibroblast Cells.

Submit: New GeneRIF Correction See all GeneRIFs (228)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itgb3 (e-PCR), detects polymorphism
- UniSTS:143631

Itgb3 (e-PCR), detects polymorphism
- UniSTS:497469

Itgb3 (e-PCR), detects polymorphism
- UniSTS:497470

D11Mit10 (e-PCR), detects polymorphism
- UniSTS:126286

Itgb3 (e-PCR), detects polymorphism
- UniSTS:470668

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to C-X3-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables extracellular matrix binding	ISO Inferred from Sequence Orthology more info
contributes_to fibrinogen binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to fibrinogen binding	ISO Inferred from Sequence Orthology more info
contributes_to fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
contributes_to insulin-like growth factor I binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
contributes_to neuregulin binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein disulfide isomerase activity	ISO Inferred from Sequence Orthology more info
enables protein kinase C binding	IPI Inferred from Physical Interaction more info	PubMed
enables vascular endothelial growth factor receptor 2 binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in apolipoprotein A-I-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apoptotic cell clearance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in apoptotic cell clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood coagulation, fibrin clot formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection morphogenesis	IC Inferred by Curator more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-matrix adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-substrate junction assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to platelet-derived growth factor stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in maintenance of postsynaptic specialization structure	ISO Inferred from Sequence Orthology more info
involved_in negative chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipoprotein metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of low-density lipoprotein receptor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in platelet activation	ISO Inferred from Sequence Orthology more info
involved_in platelet aggregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in platelet aggregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone resorption	IC Inferred by Curator more info	PubMed
involved_in positive regulation of bone resorption	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glomerular mesangial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of osteoclast differentiation	IC Inferred by Curator more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in regulation of serotonin uptake	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of trophoblast cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in symbiont entry into host cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of alpha9-beta1 integrin-ADAM8 complex	IDA Inferred from Direct Assay more info	PubMed
part_of alphav-beta3 integrin-HMGB1 complex	ISO Inferred from Sequence Orthology more info
part_of alphav-beta3 integrin-IGF-1-IGF1R complex	ISO Inferred from Sequence Orthology more info
part_of alphav-beta3 integrin-PKCalpha complex	IDA Inferred from Direct Assay more info	PubMed
part_of alphav-beta3 integrin-PKCalpha complex	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in glycinergic synapse	ISO Inferred from Sequence Orthology more info
part_of integrin alpha9-beta1 complex	TAS Traceable Author Statement more info	PubMed
part_of integrin alphav-beta3 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	ISO Inferred from Sequence Orthology more info
located_in lamellipodium membrane	ISO Inferred from Sequence Orthology more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic membrane	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: integrin beta-3

Names: GPIIIa; platelet glycoprotein IIIa (GP3A); platelet gpIIIa; platelet membrane glycoprotein IIIa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016780.2 → NP_058060.2 integrin beta-3 precursor

See identical proteins and their annotated locations for NP_058060.2

Status: VALIDATED

Source sequence(s)

BC125520, BQ033439, BX000996

Consensus CDS

CCDS25536.1

UniProtKB/Swiss-Prot

O54890, Q3TZC6

Related

ENSMUSP00000021028.5, ENSMUST00000021028.5

Conserved Domains (3) summary

pfam00362
Location:37 → 460

Integrin_beta; Integrin, beta chain

pfam07965
Location:633 → 716

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:743 → 785

Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

104498826..104561302

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532312.4 → XP_006532375.1 integrin beta-3 isoform X1

Conserved Domains (4) summary

smart00187
Location:18 → 441

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:614 → 697

Integrin_B_tail; Integrin beta tail domain

pfam08725
Location:724 → 766

Integrin_b_cyt; Integrin beta cytoplasmic domain

pfam18372
Location:443 → 472

I-EGF_1; Integrin beta epidermal growth factor like domain 1