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Itgae integrin alpha E, epithelial-associated [ Mus musculus (house mouse) ]

Gene ID: 16407, updated on 21-Apr-2024

Summary

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Official Symbol
Itgaeprovided by MGI
Official Full Name
integrin alpha E, epithelial-associatedprovided by MGI
Primary source
MGI:MGI:1298377
See related
Ensembl:ENSMUSG00000005947 AllianceGenome:MGI:1298377
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD103; aM290; alpha-E1; A530055J10; alpha-M290
Summary
Predicted to enable metal ion binding activity. Predicted to act upstream of or within cell adhesion and integrin-mediated signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; lymph node; nasal septum; and nucleus pulposus. Orthologous to human ITGAE (integrin subunit alpha E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 6.0), testis adult (RPKM 5.9) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B4; 11 45.22 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72981396..73038272)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73090505..73147449)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4732414G09 gene Neighboring gene STARR-positive B cell enhancer ABC_E10684 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1, alpha Neighboring gene STARR-positive B cell enhancer ABC_E5246 Neighboring gene nuclear cap binding subunit 3 Neighboring gene STARR-positive B cell enhancer mm9_chr11:72885264-72885564 Neighboring gene STARR-seq mESC enhancer starr_29927 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72921846-72921999 Neighboring gene STARR-seq mESC enhancer starr_29929 Neighboring gene histone H3 associated protein kinase Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 5 Neighboring gene STARR-positive B cell enhancer ABC_E1141 Neighboring gene Tax1 (human T cell leukemia virus type I) binding protein 3 Neighboring gene ER membrane protein complex subunit 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The molecular basis and cellular effects of distinct CD103 expression on CD4 and CD8 T cells. Keller HR, et al. Cell Mol Life Sci, 2021 Aug. PMID 34129058, Free PMC Article
  2. Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells. Duhan V, et al. Front Immunol, 2020. PMID 33584680, Free PMC Article
  3. Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal. Morikawa R, et al. Cell Mol Gastroenterol Hepatol, 2021. PMID 33515805, Free PMC Article
  4. Lung CD103(+) Dendritic cells of mice infected with Paracoccidioides brasiliensis contribute to Treg differentiation. Peron G, et al. Microb Pathog, 2021 Jan. PMID 33359357
  5. Pivotal role of CD103 in the development of psoriasiform dermatitis. Fukui T, et al. Sci Rep, 2020 May 20. PMID 32433498, Free PMC Article

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Escherichia coli adhesion protein FimH exacerbates colitis via CD11b[+]CD103[-] dendritic cell activation.
    Title: Escherichia coli adhesion protein FimH exacerbates colitis via CD11b(+)CD103(-) dendritic cell activation.
  2. Immunological characteristics of CD103[+]CD8[+] Tc cells in the liver of C57BL/6 mouse infected with plasmodium NSM.
    Title: Immunological characteristics of CD103(+)CD8(+) Tc cells in the liver of C57BL/6 mouse infected with plasmodium NSM.
  3. CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation.
    Title: CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation.
  4. gammadelta Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release.
    Title: γδ Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release.
  5. Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal.
    Title: Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal.
  6. Dual targeting of lymphocyte homing and retention through alpha4beta7 and alphaEbeta7 inhibition in inflammatory bowel disease.
    Title: Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease.
  7. The molecular basis and cellular effects of distinct CD103 expression on CD4 and CD8 T cells.
    Title: The molecular basis and cellular effects of distinct CD103 expression on CD4 and CD8 T cells.
  8. Lung CD103(+) Dendritic cells of mice infected with Paracoccidioides brasiliensis contribute to Treg differentiation.
    Title: Lung CD103(+) Dendritic cells of mice infected with Paracoccidioides brasiliensis contribute to Treg differentiation.
  9. Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells.
    Title: Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells.
  10. CD103(+) cDC1 and endogenous CD8(+) T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.
    Title: CD103(+) cDC1 and endogenous CD8(+) T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.
Submit: New GeneRIF Correction See all GeneRIFs (65)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC183601

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integrin alpha-E
Names
integrin alpha M290

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361245.2 → NP_001348174.1  integrin alpha-E isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL670399
    UniProtKB/TrEMBL
    Q3U4V9
    Conserved Domains (3) summary
    smart00191
    Location:565 → 624
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:195 → 370
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:667 → 938
    Integrin_alpha2; Integrin alpha

  2. NM_008399.4 → NP_032425.2  integrin alpha-E isoform 1 precursor

    See identical proteins and their annotated locations for NP_032425.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL670399
    Consensus CDS
    CCDS24995.1
    UniProtKB/Swiss-Prot
    B1AUD5, Q60677
    UniProtKB/TrEMBL
    A2T0Z1, Q3U4V9
    Related
    ENSMUSP00000006101.4, ENSMUST00000006101.4
    Conserved Domains (3) summary
    smart00191
    Location:566 → 625
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:196 → 371
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:668 → 939
    Integrin_alpha2; Integrin alpha

RNA

  1. NR_189133.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670399

  2. NR_189134.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670399

  3. NR_189135.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670399

  4. NR_189136.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670399

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    72981396..73038272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172944.2: Suppressed sequence

    Description
    NM_172944.2: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60677.2 GenPept UniProtKB/Swiss-Prot:Q60677

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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