Itga3 integrin alpha 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itga3provided by MGI
Official Full Name: integrin alpha 3provided by MGI
Primary source: MGI:MGI:96602
See related: Ensembl:ENSMUSG00000001507 AllianceGenome:MGI:96602
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD49C; GAPB3
Summary: This gene encodes a subunit of integrin family of cell surface proteins. The encoded protein undergoes post-translational processing to form a disulfide bond-linked dimer comprised of heavy and light chains. At the cell surface, the encoded protein non-covalently associates with the integrin beta-1 subunit to form a heterodimer that interacts with many extracellular matrix proteins including fibronectin and laminin. Mice lacking the encoded protein die during the first day after birth due to severe abnormalities in kidneys. Mice lacking the encoded protein specifically in the basal layer of epidermis display several skin defects and accelerated wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Expression: Broad expression in lung adult (RPKM 73.3), duodenum adult (RPKM 44.4) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 59.01 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (94935301..94967637, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (95044475..95076844, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Iron/ROS/Itga3 mediated accelerated depletion of hippocampal neural stem cell pool contributes to cognitive impairment after hemorrhagic stroke.
Title: Iron/ROS/Itga3 mediated accelerated depletion of hippocampal neural stem cell pool contributes to cognitive impairment after hemorrhagic stroke.
The Role of alpha3beta1 Integrin Modulation on Fabry Disease Podocyte Injury and Kidney Impairment.
Title: The Role of α3β1 Integrin Modulation on Fabry Disease Podocyte Injury and Kidney Impairment.
Integrin alpha3 promotes TH17 cell polarization and extravasation during autoimmune neuroinflammation.
Title: Integrin α3 promotes T(H)17 cell polarization and extravasation during autoimmune neuroinflammation.
Integrin alpha3beta1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis.
Title: Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis.
Establishment of a Murine Pro-acinar Cell Line to Characterize Roles for FGF2 and alpha3beta1 Integrins in Regulating Pro-acinar Characteristics.
Title: Establishment of a Murine Pro-acinar Cell Line to Characterize Roles for FGF2 and α3β1 Integrins in Regulating Pro-acinar Characteristics.
The study shows that ITGA3 and ITGA6 promote distinct functions and signaling by collecting duct cells on laminin substrata.
Title: The laminin binding α3 and α6 integrins cooperate to promote epithelial cell adhesion and growth.
These results demonstrate multiple roles of integrin-alpha3 at the neuromuscular junction.
Title: Multiple roles of integrin-α3 at the neuromuscular junction.
K63-linked polyubiquitination of Akt plays a previously unrecognized role in integrin alpha3beta1-dependent cell signaling required for ureteric bud development and may represent a novel mechanism whereby integrins regulate signaling pathways.
Title: Integrin α3β1 regulates kidney collecting duct development via TRAF6-dependent K63-linked polyubiquitination of Akt.
alpha3beta1-dependent alternative polyadenylation of MMP-9 mRNA occurs through a signaling pathway that involves extracellular signal-regulated kinase/mitogen-activated protein kinases.
Title: Integrin α3β1 signaling through MEK/ERK determines alternative polyadenylation of the MMP-9 mRNA transcript in immortalized mouse keratinocytes.
NR1, a novel antioxidant, ameliorated glucose-induced impaired podocyte adhesive capacity and subsequent podocyte depopulation partly through a3b1 integrin upregulation.
Title: Notoginsenoside R1 ameliorates podocyte adhesion under diabetic condition through α3β1 integrin upregulation in vitro and in vivo.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Lis2 (e-PCR), detects polymorphism
- UniSTS:498524

RH124558 (e-PCR)
- UniSTS:161380

Itga3 (e-PCR), detects polymorphism
- UniSTS:256616

Itga3 (e-PCR), detects polymorphism
- UniSTS:507001

RH125645 (e-PCR)
- UniSTS:162433

Itga3 (e-PCR), detects polymorphism
- UniSTS:143613

Itga3 (e-PCR), detects polymorphism
- UniSTS:143614

Itga3 (e-PCR), detects polymorphism
- UniSTS:143615

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables laminin binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of Rho protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dendritic spine maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dendritic spine maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exploration behavior	IGI Inferred from Genetic Interaction more info	PubMed
NOT acts_upstream_of_or_within fusion of sperm to egg plasma membrane involved in single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of Rho protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell projection organization	ISO Inferred from Sequence Orthology more info
involved_in nephron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in renal filtration	ISO Inferred from Sequence Orthology more info
involved_in skin development	ISO Inferred from Sequence Orthology more info
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in growth cone filopodium	ISO Inferred from Sequence Orthology more info
part_of integrin alpha3-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: integrin alpha-3

Names: CD49 antigen-like family member C; VLA-3 receptor, alpha 3 subunit; galactoprotein B3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001306071.1 → NP_001293000.1 integrin alpha-3 isoform 2

See identical proteins and their annotated locations for NP_001293000.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AL606480, BC053031, BQ032311

Consensus CDS

CCDS83877.1

UniProtKB/Swiss-Prot

Q62470

Related

ENSMUSP00000103368.2, ENSMUST00000107739.8

Conserved Domains (2) summary

smart00191
Location:337 → 387

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:432 → 887

Integrin_alpha2; Integrin alpha
NM_001306162.1 → NP_001293091.1 integrin alpha-3 isoform 3 precursor

See identical proteins and their annotated locations for NP_001293091.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate exon the 3' coding region, compared to variant 1. It encodes isoform 3, which has a longer and distinct C-terminus, compared to isoform 1.

Source sequence(s)

BC096741, CJ089026

Consensus CDS

CCDS83878.1

UniProtKB/Swiss-Prot

Q62470

Related

ENSMUSP00000113556.2, ENSMUST00000120375.8

Conserved Domains (2) summary

smart00191
Location:368 → 418

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:463 → 918

Integrin_alpha2; Integrin alpha
NM_013565.3 → NP_038593.1 integrin alpha-3 isoform 1 preproprotein

See identical proteins and their annotated locations for NP_038593.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.

Source sequence(s)

BC053031, BQ032311

Consensus CDS

CCDS25271.1

UniProtKB/Swiss-Prot

Q08441, Q08442, Q5SWA8, Q5SWB9, Q62470, Q6P6I1

Related

ENSMUSP00000001548.8, ENSMUST00000001548.14

Conserved Domains (2) summary

smart00191
Location:368 → 418

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:463 → 918

Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

94935301..94967637 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532310.5 → XP_006532373.1 integrin alpha-3 isoform X1

See identical proteins and their annotated locations for XP_006532373.1

UniProtKB/Swiss-Prot

Q62470

Conserved Domains (2) summary

smart00191
Location:368 → 418

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:463 → 918

Integrin_alpha2; Integrin alpha
XM_006532311.5 → XP_006532374.1 integrin alpha-3 isoform X2

See identical proteins and their annotated locations for XP_006532374.1

UniProtKB/Swiss-Prot

Q08441, Q08442, Q5SWA8, Q5SWB9, Q62470, Q6P6I1

Conserved Domains (2) summary

smart00191
Location:368 → 418

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:463 → 918

Integrin_alpha2; Integrin alpha