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Irs3 insulin receptor substrate 3 [ Mus musculus (house mouse) ]

Gene ID: 16369, updated on 8-Feb-2024

Summary

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Official Symbol
Irs3provided by MGI
Official Full Name
insulin receptor substrate 3provided by MGI
Primary source
MGI:MGI:1194882
See related
Ensembl:ENSMUSG00000047182 AllianceGenome:MGI:1194882
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables phosphatidylinositol 3-kinase binding activity. Predicted to be involved in insulin receptor signaling pathway. Located in plasma membrane. Is expressed in embryo; heart; liver; lung; and metanephros. Orthologous to human IRS3P (insulin receptor substrate 3, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 20.1), mammary gland adult (RPKM 17.0) and 6 other tissues See more
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Genomic context

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Location:
5 G2; 5 76.59 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137641294..137643976, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137643032..137645714, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14649 Neighboring gene predicted gene 20605 Neighboring gene leucine-rich repeats and calponin homology (CH) domain containing 4 Neighboring gene sin3 associated polypeptide Neighboring gene ArfGAP with FG repeats 2 Neighboring gene STARR-positive B cell enhancer ABC_E236 Neighboring gene predicted gene 15498

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning of the mouse insulin receptor substrate-3 (mIRS-3) promoter, and its regulation by p53. Sciacchitano S, et al. Mol Endocrinol, 2002 Jul. PMID 12089352
  2. Insulin receptor substrate 3 is not essential for growth or glucose homeostasis. Liu SC, et al. J Biol Chem, 1999 Jun 18. PMID 10364263
  3. IRS-3 mediates insulin-induced glucose uptake in differentiated IRS-2(-/-) brown adipocytes. Escribano O, et al. Mol Cell Endocrinol, 2007 Mar 30. PMID 17316975
  4. Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes. Arribas M, et al. J Biol Chem, 2003 Nov 14. PMID 12944402
  5. Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice. Terauchi Y, et al. J Biol Chem, 2003 Apr 18. PMID 12493745

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2.
    Title: Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.
  2. These results provide evidences suggesting that IRS-3/PI 3-kinase/PKC zeta signaling is the main responsible for the insulin-induced glucose uptake observed upon differentiation of brown adipocytes lacking IRS-2.
    Title: IRS-3 mediates insulin-induced glucose uptake in differentiated IRS-2(-/-) brown adipocytes.
  3. IRS-3 does not play a role compensating for the loss of IRS-2 in maintaining glucose homeostasis and the severity of diabetes in IRS-2(-/-) mice depends upon genetic background
    Title: Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice.
  4. These data indicate that both insulin receptor substrate (IRS)-1 and -3, but not IRS-2 or IRS-4, play key roles in the differentiation of brown adipocytes.
    Title: Differential roles of insulin receptor substrates in brown adipocyte differentiation.
  5. our study demonstrates that the mIRS-3 promoter is regulated by p53 at the transcriptional level. The inhibition of mIRS-3 promoter by wild-type p53, and its de-repression by tumor-derived p53 mutants
    Title: Cloning of the mouse insulin receptor substrate-3 (mIRS-3) promoter, and its regulation by p53.
  6. IRS-3 has a role in the insulin signaling of IRS-1-deficient brown adipocytes but not at the same level as IRS-1
    Title: Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC106831

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol 3-kinase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphatidylinositol 3-kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol 3-kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
insulin receptor substrate 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010571.3 → NP_034701.1  insulin receptor substrate 3

    See identical proteins and their annotated locations for NP_034701.1

    Status: PROVISIONAL

    Source sequence(s)
    AC124730
    Consensus CDS
    CCDS19773.1
    UniProtKB/TrEMBL
    O54718
    Related
    ENSMUSP00000060844.4, ENSMUST00000057314.4
    Conserved Domains (2) summary
    cd01204
    Location:159 → 273
    PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
    cd01257
    Location:31 → 132
    PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137641294..137643976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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