Il7r interleukin 7 receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il7rprovided by MGI
Official Full Name: interleukin 7 receptorprovided by MGI
Primary source: MGI:MGI:96562
See related: Ensembl:ENSMUSG00000003882 AllianceGenome:MGI:96562
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD127; IL-7Ralpha
Summary: Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008]
Expression: Biased expression in spleen adult (RPKM 3.1), thymus adult (RPKM 2.6) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 4.16 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (9505880..9530270, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (9506159..9529941, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion.
Title: IL-7 receptor signaling drives human B-cell progenitor differentiation and expansion.
Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2.
Title: Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2.
IL-7 Receptor Drives Early T Lineage Progenitor Expansion.
Title: IL-7 Receptor Drives Early T Lineage Progenitor Expansion.
Liver X receptor beta is required for the survival of single-positive thymocytes by regulating IL-7Ralpha expression.
Title: Liver X receptor β is required for the survival of single-positive thymocytes by regulating IL-7Rα expression.
Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice.
Title: Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice.
IL7Ralpha, but not Flk2, is required for hematopoietic stem cell reconstitution of tissue-resident lymphoid cells.
Title: IL7Rα, but not Flk2, is required for hematopoietic stem cell reconstitution of tissue-resident lymphoid cells.
Interleukin-7 receptor alpha mutational activation can initiate precursor B-cell acute lymphoblastic leukemia.
Title: Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia.
Overexpression of wild-type IL-7Ralpha promotes T-cell acute lymphoblastic leukemia/lymphoma.
Title: Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma.
Identification of alternatively spliced Il7r transcripts in mouse T cells that encode soluble IL-7Ralpha.
Title: Identification of alternatively spliced Il7r transcripts in mouse T cells that encode soluble IL-7Rα.
Targeting the interleukin-7 receptor alpha by an anti-CD127 monoclonal antibody improves allergic airway inflammation in mice.
Title: Targeting the interleukin-7 receptor alpha by an anti-CD127 monoclonal antibody improves allergic airway inflammation in mice.

Submit: New GeneRIF Correction See all GeneRIFs (107)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Il7r (e-PCR), detects polymorphism
- UniSTS:265228

Il7r (e-PCR), detects polymorphism
- UniSTS:259185

D15Mit264 (e-PCR), detects polymorphism
- UniSTS:127637

PMC125811P1 (e-PCR)
- UniSTS:270516

M29697 (e-PCR)
- UniSTS:160437

Il7r (e-PCR), detects polymorphism
- UniSTS:256439

Il7r (e-PCR), detects polymorphism
- UniSTS:143583

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within B cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemopoiesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immunoglobulin production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lymph node development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell size	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell size	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: interleukin-7 receptor subunit alpha

Names: IL-7 receptor alpha chain; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; interleukin 7 receptor alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355680.1 → NP_001342609.1 interleukin-7 receptor subunit alpha isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC162301

Consensus CDS

CCDS88732.1

UniProtKB/TrEMBL

A0A2I3BRC2, Q5FW78

Related

ENSMUSP00000154530.2, ENSMUST00000228782.2

Conserved Domains (1) summary

pfam00041
Location:131 → 219

fn3; Fibronectin type III domain
NM_008372.4 → NP_032398.3 interleukin-7 receptor subunit alpha isoform 1 precursor

See identical proteins and their annotated locations for NP_032398.3

Status: VALIDATED

Source sequence(s)

AK040364, AK042264, BC089571, BY776757

Consensus CDS

CCDS27376.1

UniProtKB/Swiss-Prot

P16872, Q9R0C1

UniProtKB/TrEMBL

Q8C9W4

Related

ENSMUSP00000003981.5, ENSMUST00000003981.6

Conserved Domains (1) summary

pfam00041
Location:131 → 219

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

9505880..9530270 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159168.1 → XP_036015061.1 interleukin-7 receptor subunit alpha isoform X1

Conserved Domains (1) summary

cl21522
Location:11 → 99

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_036159169.1 → XP_036015062.1 interleukin-7 receptor subunit alpha isoform X2