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Il6 interleukin 6 [ Mus musculus (house mouse) ]

Gene ID: 16193, updated on 7-Jan-2025

Summary

Official Symbol
Il6provided by MGI
Official Full Name
interleukin 6provided by MGI
Primary source
MGI:MGI:96559
See related
Ensembl:ENSMUSG00000025746 AllianceGenome:MGI:96559
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il-6
Summary
This gene encodes a member of the interleukin family of cytokines that have important functions in immune response, hematopoiesis, inflammation and the acute phase response. The ectopic overexpression of the encoded protein in mice results in excessive plasma cells in circulation, leading to death. Mice lacking the encoded protein exhibit abnormalities in hepatic acute phase response, some immune mechanisms, bone resorption in response to estrogen, liver regeneration and wound healing. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Il6 in Genome Data Viewer
Location:
5 B1; 5 15.7 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30218112..30224973)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30013114..30019975)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12743 Neighboring gene protein phosphatase 1, regulatory subunit 10 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11285 Neighboring gene vacuole membrane protein 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9637 Neighboring gene STARR-seq mESC enhancer starr_12744 Neighboring gene STARR-positive B cell enhancer mm9_chr5:30299320-30299620 Neighboring gene RIKEN cDNA A230098N10 gene Neighboring gene STARR-seq mESC enhancer starr_12745 Neighboring gene STARR-seq mESC enhancer starr_12746 Neighboring gene thymidylate synthase Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:30400119-30400228 Neighboring gene STARR-seq mESC enhancer starr_12748 Neighboring gene STARR-seq mESC enhancer starr_12749 Neighboring gene kinesin family member 2C pseudogene Neighboring gene kinesin superfamily protein 2C pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity  
enables cytokine activity PubMed 
enables cytokine activity  
enables growth factor activity  
enables growth factor activity  
enables growth factor activity  
enables interleukin-6 receptor binding PubMed 
contributes_to interleukin-6 receptor binding  
enables interleukin-6 receptor binding  
enables protein binding PubMed 
enables signaling receptor binding  
Items 1 - 25 of 131
Process Evidence Code Pubs
acts_upstream_of_or_within T cell activation PubMed 
involved_in T follicular helper cell differentiation PubMed 
involved_in T-helper 17 cell lineage commitment PubMed 
involved_in T-helper 17 cell lineage commitment PubMed 
acts_upstream_of T-helper 2 cell differentiation PubMed 
involved_in acute-phase response  
acts_upstream_of_or_within branching involved in salivary gland morphogenesis PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis PubMed 
involved_in cell redox homeostasis  
acts_upstream_of_or_within cellular response to hepatocyte growth factor stimulus PubMed 
involved_in cellular response to hydrogen peroxide  
acts_upstream_of_or_within cellular response to interleukin-1 PubMed 
involved_in cellular response to interleukin-17 PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide PubMed 
acts_upstream_of_or_within cellular response to lipopolysaccharide PubMed 
acts_upstream_of_or_within cellular response to tumor necrosis factor PubMed 
involved_in cellular response to virus PubMed 
involved_in cytokine-mediated signaling pathway  
acts_upstream_of_or_within defense response to protozoan PubMed 
involved_in defense response to virus  
involved_in endocrine pancreas development PubMed 
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis PubMed 
acts_upstream_of_or_within_positive_effect gene expression PubMed 
involved_in germinal center B cell differentiation PubMed 
involved_in glucagon secretion PubMed 
involved_in glucose homeostasis PubMed 
acts_upstream_of_or_within glucose homeostasis PubMed 
involved_in glucose homeostasis  
involved_in hepatic immune response  
involved_in hepatocyte proliferation PubMed 
involved_in inflammatory response  
involved_in inflammatory response to wounding PubMed 
involved_in inflammatory response to wounding  
acts_upstream_of_or_within interleukin-6-mediated signaling pathway PubMed 
involved_in interleukin-6-mediated signaling pathway PubMed 
involved_in interleukin-6-mediated signaling pathway PubMed 
involved_in interleukin-6-mediated signaling pathway  
involved_in liver regeneration PubMed 
acts_upstream_of_or_within muscle cell cellular homeostasis PubMed 
acts_upstream_of_or_within myeloid cell homeostasis PubMed 
involved_in negative regulation of apoptotic process  
involved_in negative regulation of bone resorption PubMed 
involved_in negative regulation of cell population proliferation  
acts_upstream_of_or_within negative regulation of chemokine production PubMed 
acts_upstream_of_or_within negative regulation of chemokine production PubMed 
involved_in negative regulation of collagen biosynthetic process  
involved_in negative regulation of gluconeogenesis  
acts_upstream_of_or_within negative regulation of hormone secretion PubMed 
involved_in negative regulation of interleukin-1-mediated signaling pathway PubMed 
involved_in negative regulation of membrane potential  
involved_in negative regulation of muscle organ development  
involved_in negative regulation of neuron apoptotic process  
acts_upstream_of negative regulation of primary miRNA processing  
involved_in neuron projection development  
acts_upstream_of_or_within neutrophil apoptotic process PubMed 
acts_upstream_of_or_within neutrophil apoptotic process PubMed 
involved_in neutrophil apoptotic process  
involved_in positive regulation of B cell activation  
involved_in positive regulation of DNA replication  
involved_in positive regulation of DNA-binding transcription factor activity  
acts_upstream_of_or_within positive regulation of DNA-templated transcription PubMed 
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of ERK1 and ERK2 cascade  
acts_upstream_of_or_within positive regulation of MAPK cascade  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of T cell proliferation  
involved_in positive regulation of T-helper 2 cell cytokine production PubMed 
acts_upstream_of_or_within positive regulation of T-helper 2 cell differentiation PubMed 
involved_in positive regulation of acute inflammatory response  
involved_in positive regulation of apoptotic DNA fragmentation  
involved_in positive regulation of apoptotic process  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation  
acts_upstream_of_or_within positive regulation of cell proliferation in bone marrow PubMed 
involved_in positive regulation of chemokine production  
involved_in positive regulation of cytokine production involved in inflammatory response  
acts_upstream_of_or_within positive regulation of epithelial cell proliferation PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation PubMed 
involved_in positive regulation of epithelial to mesenchymal transition  
involved_in positive regulation of extracellular matrix disassembly  
acts_upstream_of_or_within positive regulation of gene expression PubMed 
acts_upstream_of_or_within positive regulation of gene expression  
involved_in positive regulation of gene expression  
involved_in positive regulation of glial cell proliferation  
involved_in positive regulation of gliogenesis PubMed 
involved_in positive regulation of immunoglobulin production PubMed 
involved_in positive regulation of immunoglobulin production  
involved_in positive regulation of interleukin-1 beta production  
involved_in positive regulation of interleukin-10 production  
involved_in positive regulation of interleukin-17 production PubMed 
involved_in positive regulation of interleukin-21 production PubMed 
involved_in positive regulation of interleukin-6 production  
involved_in positive regulation of interleukin-8 production  
acts_upstream_of_or_within positive regulation of leukocyte adhesion to vascular endothelial cell  
involved_in positive regulation of neuron differentiation  
involved_in positive regulation of neuron projection development  
involved_in positive regulation of nitric oxide biosynthetic process  
involved_in positive regulation of osteoblast differentiation  
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation  
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
acts_upstream_of positive regulation of platelet aggregation  
involved_in positive regulation of protein import into nucleus  
involved_in positive regulation of receptor signaling pathway via JAK-STAT  
involved_in positive regulation of receptor signaling pathway via JAK-STAT  
involved_in positive regulation of receptor signaling pathway via STAT PubMed 
acts_upstream_of positive regulation of receptor signaling pathway via STAT  
involved_in positive regulation of smooth muscle cell proliferation  
involved_in positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of translation  
involved_in positive regulation of transmission of nerve impulse  
involved_in positive regulation of tumor necrosis factor production  
involved_in positive regulation of tyrosine phosphorylation of STAT protein  
involved_in positive regulation of vascular endothelial growth factor production  
acts_upstream_of_or_within regulation of apoptotic process PubMed 
acts_upstream_of_or_within regulation of cell population proliferation PubMed 
involved_in regulation of cell shape  
involved_in regulation of circadian sleep/wake cycle, non-REM sleep  
involved_in regulation of glucagon secretion PubMed 
involved_in regulation of glucagon secretion  
involved_in regulation of insulin secretion PubMed 
involved_in regulation of insulin secretion  
involved_in regulation of vascular endothelial growth factor production  
involved_in response to activity PubMed 
involved_in response to glucocorticoid  
acts_upstream_of_or_within response to wounding PubMed 
involved_in vascular endothelial growth factor production  
involved_in vascular endothelial growth factor production  
Items 1 - 25 of 131
Component Evidence Code Pubs
located_in external side of plasma membrane PubMed 
is_active_in extracellular space  
is_active_in extracellular space PubMed 
located_in extracellular space PubMed 
is_active_in extracellular space  
located_in extracellular space  
part_of interleukin-6 receptor complex  
part_of interleukin-6 receptor complex PubMed 
part_of interleukin-6 receptor complex  

General protein information

Preferred Names
interleukin-6
Names
B-cell hybridoma growth factor
interleukin HP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001314054.1NP_001300983.1  interleukin-6 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC112933, AK150440, BC145409
    Consensus CDS
    CCDS84856.1
    UniProtKB/TrEMBL
    A0A0G2JGF4
    Related
    ENSMUSP00000143544.2, ENSMUST00000195978.5
    Conserved Domains (1) summary
    cl02473
    Location:27157
    IL6; Interleukin-6/G-CSF/MGF family
  2. NM_031168.2NP_112445.1  interleukin-6 isoform 1 precursor

    See identical proteins and their annotated locations for NP_112445.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC112933, AK150440
    Consensus CDS
    CCDS19153.1
    UniProtKB/Swiss-Prot
    P08505, Q3UCQ0, Q8BN26
    UniProtKB/TrEMBL
    A2RTD1, Q0PMN1
    Related
    ENSMUSP00000026845.8, ENSMUST00000026845.12
    Conserved Domains (1) summary
    pfam00489
    Location:27210
    IL6; Interleukin-6/G-CSF/MGF family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    30218112..30224973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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