Il4 interleukin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il4provided by MGI
Official Full Name: interleukin 4provided by MGI
Primary source: MGI:MGI:96556
See related: Ensembl:ENSMUSG00000000869 AllianceGenome:MGI:96556
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il-4; BSF-1
Summary: Enables cytokine activity. Involved in several processes, including innate immune response in mucosa; negative regulation of white fat cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including T-helper cell differentiation; positive regulation of macromolecule metabolic process; and regulation of leukocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; colon; hemolymphoid system; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 31.97 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (53503287..53509492, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (53612460..53618665, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IgE and anaphylaxis specific to the carbohydrate alpha-gal depend on IL-4.
Title: IgE and anaphylaxis specific to the carbohydrate alpha-gal depend on IL-4.
IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress.
Title: IL-4 activates ULK1/Atg9a/Rab9 in asthma, NLRP3 inflammasomes, and Golgi fragmentation by increasing autophagy flux and mitochondrial oxidative stress.
STAT6 tunes maximum T cell IL-4 production from stochastically regulated Il4 alleles.
Title: STAT6 tunes maximum T cell IL-4 production from stochastically regulated Il4 alleles.
IL-4 activates the futile triacylglyceride cycle for glucose utilization in white adipocytes.
Title: IL-4 activates the futile triacylglyceride cycle for glucose utilization in white adipocytes.
The H3K9 demethylase plant homeodomain finger protein 2 regulates interleukin 4 production in CD4[+] T cells.
Title: The H3K9 demethylase plant homeodomain finger protein 2 regulates interleukin 4 production in CD4(+) T cells.
An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis.
Title: An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis.
[Cold stimulation promotes interleukin-4 secretion by mucosal-associated invariant T cells in the adipose tissue to promote adipose browning in mice].
Title: [Cold stimulation promotes interleukin-4 secretion by mucosal-associated invariant T cells in the adipose tissue to promote adipose browning in mice].
IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development.
Title: IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development.
IL-4 Signaling Promotes Myoblast Differentiation and Fusion by Enhancing the Expression of MyoD, Myogenin, and Myomerger.
Title: IL-4 Signaling Promotes Myoblast Differentiation and Fusion by Enhancing the Expression of MyoD, Myogenin, and Myomerger.
Interleukin-4 mitigates anxiety-like behavior and loss of neurons and fiber tracts in limbic structures in a microglial PPARgamma-dependent manner after traumatic brain injury.
Title: Interleukin-4 mitigates anxiety-like behavior and loss of neurons and fiber tracts in limbic structures in a microglial PPARγ-dependent manner after traumatic brain injury.

Submit: New GeneRIF Correction See all GeneRIFs (518)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (17) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Il4 (e-PCR), detects polymorphism
- UniSTS:463949

D11Mit111 (e-PCR), detects polymorphism
- UniSTS:126300

Il4 (e-PCR), detects polymorphism
- UniSTS:143565

Il4 (e-PCR), detects polymorphism
- UniSTS:143566

UniSTS:143568 (e-PCR)
- UniSTS:143568

Il4 (e-PCR), detects polymorphism
- UniSTS:143568

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor binding	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-4 receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of B cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within B cell costimulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of MHC class II biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within T-helper 1 cell lineage commitment	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T-helper 2 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of activated T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in activation of Janus kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to protozoan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response in mucosa	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-4-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-4-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of isotype switching to IgE isotypes	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of isotype switching to IgG isotypes	IDA Inferred from Direct Assay more info	PubMed
involved_in macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in myeloid dendritic cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of T-helper 17 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chronic inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of white fat cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in neuroinflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ATP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of B cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MHC class II biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T-helper 2 cell cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of activated T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of amyloid-beta clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular respiration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of eosinophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of immunoglobulin production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of isotype switching to IgE isotypes	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macroautophagy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell degranulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mononuclear cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of myoblast fusion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of reactive oxygen species biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of proton transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-4

Names: B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1; IGG1 induction factor; lymphocyte stimulatory factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021283.2 → NP_067258.1 interleukin-4 precursor

See identical proteins and their annotated locations for NP_067258.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.

Source sequence(s)

BC027514, M25892

Consensus CDS

CCDS24682.1

UniProtKB/Swiss-Prot

P07750

UniProtKB/TrEMBL

Q91Y50

Related

ENSMUSP00000000889.7, ENSMUST00000000889.7

Conserved Domains (1) summary

smart00190
Location:1 → 140

IL4_13; Interleukins 4 and 13

RNA

NR_027491.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

AA199406, BC027514, BX529138

Related

ENSMUST00000150568.8