Il2rb interleukin 2 receptor, beta chain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il2rbprovided by MGI
Official Full Name: interleukin 2 receptor, beta chainprovided by MGI
Primary source: MGI:MGI:96550
See related: Ensembl:ENSMUSG00000068227 AllianceGenome:MGI:96550
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p70; CD122; IL15Rbeta; Il-2Rbeta; IL-15Rbeta; Il-2/15Rbeta
Summary: The interleukin 2 receptor is composed of alpha and beta subunits. The beta subunit encoded by this gene is very homologous to the human beta subunit and also shows structural similarity to other cytokine receptors. [provided by RefSeq, Jul 2008]
Expression: Biased expression in spleen adult (RPKM 30.6), mammary gland adult (RPKM 14.0) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.52 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (78363456..78396569, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (78479256..78511621, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of miR-497-5p Improves Sepsis-Induced Acute Lung Injury by Targeting IL2RB.
Title: Downregulation of miR-497-5p Improves Sepsis-Induced Acute Lung Injury by Targeting IL2RB.
Chronic shift-lag promotes NK cell ageing and impairs immunosurveillance in mice by decreasing the expression of CD122.
Title: Chronic shift-lag promotes NK cell ageing and impairs immunosurveillance in mice by decreasing the expression of CD122.
The Abundance and Availability of Cytokine Receptor IL-2Rbeta (CD122) Constrain the Lymphopenia-Induced Homeostatic Proliferation of Naive CD4 T Cells.
Title: The Abundance and Availability of Cytokine Receptor IL-2Rβ (CD122) Constrain the Lymphopenia-Induced Homeostatic Proliferation of Naive CD4 T Cells.
Combined costimulatory and CD122 blockade improved survival of transplanted tissue in mice and nonhuman primates by controlling proliferation and effector function of CD8+ T cells.
Title: CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection.
Diabetes was accelerated in male and female NOD mice in which IL-2Rbeta signaling was modestly and selectively reduced in T cells.
Title: Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice.
The larger pool of IL-2Rbeta chains in CD8+ T cells is required to sustain IL-2 signaling and contributes to the quantitatively greater proliferative response to IL-2 relative to that of CD4+ mouse primary T cell cultures.
Title: IL-2Rβ abundance differentially tunes IL-2 signaling dynamics in CD4(+) and CD8(+) T cells.
Genetic ablation of the IL2Rbeta chain on CD8(+) T cells restrains inhibitory receptor induction, in particular 2B4 and Tim-3; precludes terminal differentiation of highly defective PD-1(hi) effectors; and rescues memory T-cell development and responsiveness to IL-7-dependent signals. Together, we ascribe a previously unexpected role to IL-2 and IL-15 as instigators of CD8(+) T-cell exhaustion during chronic viral infe...
Title: IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection.
c-REL, but not IkappaBNS, controlled the generation of classical CD25(+)Foxp3(-) precursors via direct binding to the Cd25 locus; propose that CD4(+)GITR(+)CD122(+)CD25(-)Foxp3(-) cells represent a Treg pre-precursor population, whose transition into Treg precursors is mediated via c-REL
Title: c-REL and IκB(NS) Govern Common and Independent Steps of Regulatory T Cell Development from Novel CD122-Expressing Pre-Precursors.
Results indicate that conjugated-interleukin-2 (IL2) protein derived from NKTR-214 occupy interleukin-2 (IL2) receptor complex (IL2Ralphabetagamma) to a greater extent compared to free-IL2 protein.
Title: Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy.
Renal lesions are indeed modulated by intrinsic glomerular cells through the gamma-C/IL-2-beta receptor response, to date classically described only in immune cells.
Title: Glomerular common gamma chain confers B- and T-cell-independent protection against glomerulonephritis.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Chemically induced (ENU) (3)
Endonuclease-mediated (3)

General gene information

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Markers

Il2rb (e-PCR), detects polymorphism
- UniSTS:265223

Il2rb (e-PCR), detects polymorphism
- UniSTS:143559

M28052 (e-PCR)
- UniSTS:160482

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-15 receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-2 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-2 binding	IPI Inferred from Physical Interaction more info	PubMed
enables interleukin-2 binding	ISO Inferred from Sequence Orthology more info
enables interleukin-2 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-15-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-2-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: interleukin-2 receptor subunit beta

Names: IL-15 receptor beta chain; IL-2 receptor beta chain; IL-2 receptor subunit beta; IL-2/15 receptor-beta; IL-2R subunit beta; IL-2RB; high affinity IL-2 receptor subunit beta; p70-75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008368.4 → NP_032394.1 interleukin-2 receptor subunit beta precursor

See identical proteins and their annotated locations for NP_032394.1

Status: REVIEWED

Source sequence(s)

AK017288, BQ033566

Consensus CDS

CCDS27616.1

UniProtKB/Swiss-Prot

P16297, Q3TZT2

UniProtKB/TrEMBL

Q3TEQ2, Q8CBU1

Related

ENSMUSP00000086820.2, ENSMUST00000089398.9

Conserved Domains (2) summary

cd00063
Location:135 → 232

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18707
Location:32 → 124

IL2RB_N1; Interleukin-2 receptor subunit beta N-terminal domain 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

78363456..78396569 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520478.4 → XP_006520541.1 interleukin-2 receptor subunit beta isoform X1

See identical proteins and their annotated locations for XP_006520541.1

UniProtKB/Swiss-Prot

P16297, Q3TZT2

UniProtKB/TrEMBL

Q3TEQ2, Q8CBU1

Conserved Domains (2) summary

cd00063
Location:135 → 232

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18707
Location:32 → 124

IL2RB_N1; Interleukin-2 receptor subunit beta N-terminal domain 1
XM_006520477.4 → XP_006520540.1 interleukin-2 receptor subunit beta isoform X1

See identical proteins and their annotated locations for XP_006520540.1

UniProtKB/Swiss-Prot

P16297, Q3TZT2

UniProtKB/TrEMBL

Q3TEQ2, Q8CBU1

Conserved Domains (2) summary

cd00063
Location:135 → 232

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18707
Location:32 → 124

IL2RB_N1; Interleukin-2 receptor subunit beta N-terminal domain 1
XM_006520479.2 → XP_006520542.1 interleukin-2 receptor subunit beta isoform X1

See identical proteins and their annotated locations for XP_006520542.1

UniProtKB/Swiss-Prot

P16297, Q3TZT2

UniProtKB/TrEMBL

Q3TEQ2, Q8CBU1

Conserved Domains (2) summary

cd00063
Location:135 → 232

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18707
Location:32 → 124

IL2RB_N1; Interleukin-2 receptor subunit beta N-terminal domain 1
XM_006520480.3 → XP_006520543.1 interleukin-2 receptor subunit beta isoform X1

See identical proteins and their annotated locations for XP_006520543.1

UniProtKB/Swiss-Prot

P16297, Q3TZT2

UniProtKB/TrEMBL

Q3TEQ2, Q8CBU1

Related

ENSMUSP00000127006.2, ENSMUST00000163494.3

Conserved Domains (2) summary

cd00063
Location:135 → 232

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18707
Location:32 → 124

IL2RB_N1; Interleukin-2 receptor subunit beta N-terminal domain 1
XM_006520481.4 → XP_006520544.1 interleukin-2 receptor subunit beta isoform X1

See identical proteins and their annotated locations for XP_006520544.1

UniProtKB/Swiss-Prot

P16297, Q3TZT2

UniProtKB/TrEMBL

Q3TEQ2, Q8CBU1

Conserved Domains (2) summary

cd00063
Location:135 → 232

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18707
Location:32 → 124

IL2RB_N1; Interleukin-2 receptor subunit beta N-terminal domain 1