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Il11 interleukin 11 [ Mus musculus (house mouse) ]

Gene ID: 16156, updated on 11-Apr-2024

Summary

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Official Symbol
Il11provided by MGI
Official Full Name
interleukin 11provided by MGI
Primary source
MGI:MGI:107613
See related
Ensembl:ENSMUSG00000004371 AllianceGenome:MGI:107613
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IL-11
Summary
Enables cytokine activity and interleukin-11 receptor binding activity. Acts upstream of or within positive regulation of cell population proliferation. Located in cytoplasm. Orthologous to human IL11 (interleukin 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 3.5), colon adult (RPKM 0.3) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Il11 in Genome Data Viewer
Location:
7 A1; 7 2.76 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4775372..4785877, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4772373..4782907, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17937 Neighboring gene cytochrome c oxidase subunit 6B2 Neighboring gene golgi associated RAB2 interactor family member 5B Neighboring gene transmembrane protein 190 Neighboring gene transmembrane protein 238 Neighboring gene STARR-positive B cell enhancer ABC_E6507 Neighboring gene predicted gene, 57780 Neighboring gene ribosomal protein L28

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome. Ng B, et al. Arterioscler Thromb Vasc Biol, 2023 May. PMID 36924234, Free PMC Article
  2. Neutralization of interleukin-11 attenuates silica particles-induced pulmonary inflammation and fibrosis in vivo. Ma J, et al. J Environ Sci (China), 2023 Apr. PMID 36503802
  3. Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis. Dong B, et al. Nat Commun, 2022 Nov 23. PMID 36424386, Free PMC Article
  4. MEK/ERK/RUNX2 Pathway-Mediated IL-11 Autocrine Promotes the Activation of Müller Glial Cells during Diabetic Retinopathy. Ji N, et al. Curr Eye Res, 2022 Dec. PMID 36154781
  5. IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis. Ng B, et al. Int J Mol Sci, 2022 Mar 24. PMID 35408908, Free PMC Article

See all (103) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice.
    Title: ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice.
  2. Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing.
    Title: Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing.
  3. Macrophages release IL11-containing filopodial tip vesicles and contribute to renal interstitial inflammation.
    Title: Macrophages release IL11-containing filopodial tip vesicles and contribute to renal interstitial inflammation.
  4. The effect of hepatic stellate cell derived-IL-11 on hepatocyte injury in hepatic fibrosis.
    Title: The effect of hepatic stellate cell derived-IL-11 on hepatocyte injury in hepatic fibrosis.
  5. Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction.
    Title: Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction.
  6. IL11 activates the placental inflammasome to drive preeclampsia.
    Title: IL11 activates the placental inflammasome to drive preeclampsia.
  7. IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome.
    Title: IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome.
  8. IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer.
    Title: IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer.
  9. Neutralization of interleukin-11 attenuates silica particles-induced pulmonary inflammation and fibrosis in vivo.
    Title: Neutralization of interleukin-11 attenuates silica particles-induced pulmonary inflammation and fibrosis in vivo.
  10. Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis.
    Title: Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (58)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
  
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
  
enables growth factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables interleukin-11 receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in interleukin-11-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
interleukin-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290423.2 → NP_001277352.1  interleukin-11 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2-5 all encode the same isoform (2).
    Source sequence(s)
    AC162034
    Consensus CDS
    CCDS71881.1
    UniProtKB/TrEMBL
    F7A7F2
    Related
    ENSMUSP00000131168.3, ENSMUST00000163481.3
    Conserved Domains (1) summary
    pfam07400
    Location:2 → 140
    IL11; Interleukin 11

  2. NM_001412482.1 → NP_001399411.1  interleukin-11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162034
    UniProtKB/TrEMBL
    F7A7F2
    Related
    ENSMUSP00000157240.2, ENSMUST00000234277.2

  3. NM_001412483.1 → NP_001399412.1  interleukin-11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162034
    UniProtKB/TrEMBL
    F7A7F2

  4. NM_001412484.1 → NP_001399413.1  interleukin-11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC162034
    UniProtKB/TrEMBL
    F7A7F2

  5. NM_008350.5 → NP_032376.1  interleukin-11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032376.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC162034
    Consensus CDS
    CCDS39740.1
    UniProtKB/Swiss-Prot
    P47873
    UniProtKB/TrEMBL
    A3KPB8, Q3V0U3
    Related
    ENSMUSP00000092492.6, ENSMUST00000094892.12
    Conserved Domains (1) summary
    pfam07400
    Location:23 → 199
    IL11; Interleukin 11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4775372..4785877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152699.1 → XP_036008592.1  interleukin-11 isoform X1

    UniProtKB/TrEMBL
    F7A7F2
    Conserved Domains (1) summary
    pfam07400
    Location:2 → 140
    IL11; Interleukin 11

  2. XM_017321988.3 → XP_017177477.1  interleukin-11 isoform X2

    Conserved Domains (1) summary
    pfam07400
    Location:2 → 145
    IL11; Interleukin 11
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47873.1 GenPept UniProtKB/Swiss-Prot:P47873

Gene LinkOut

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