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Ifna2 interferon alpha 2 [ Mus musculus (house mouse) ]

Gene ID: 15965, updated on 4-Jan-2025

Summary

Official Symbol
Ifna2provided by MGI
Official Full Name
interferon alpha 2provided by MGI
Primary source
MGI:MGI:107666
See related
Ensembl:ENSMUSG00000078354 AllianceGenome:MGI:107666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ifa2; If1ai7
Summary
Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including lymphocyte activation involved in immune response; response to exogenous dsRNA; and type I interferon-mediated signaling pathway. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Crimean-Congo hemorrhagic fever; common cold; hepatitis B; liver disease (multiple); and sarcoidosis. Orthologous to several human genes including IFNA4 (interferon alpha 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See Ifna2 in Genome Data Viewer
Location:
4 C4; 4 42.02 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (88601444..88602016, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (88683207..88683779, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene interferon-alpha 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10726 Neighboring gene interferon alpha 16 Neighboring gene interferon alpha B Neighboring gene interferon-alpha 2 pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity  
enables cytokine activity  
enables cytokine activity  
enables cytokine receptor binding  
enables type I interferon receptor binding  
Process Evidence Code Pubs
involved_in B cell activation involved in immune response  
involved_in T cell activation involved in immune response  
involved_in adaptive immune response  
involved_in defense response to virus  
involved_in humoral immune response  
involved_in natural killer cell activation involved in immune response  
involved_in response to exogenous dsRNA  
involved_in signal transduction  
involved_in type I interferon-mediated signaling pathway  
Component Evidence Code Pubs
is_active_in extracellular space  
located_in extracellular space  
is_active_in extracellular space  

General protein information

Preferred Names
interferon alpha-2
Names
IFN-alpha-2
interferon 1ai7
interferon alpha family, gene 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010503.2NP_034633.2  interferon alpha-2 precursor

    See identical proteins and their annotated locations for NP_034633.2

    Status: VALIDATED

    Source sequence(s)
    AL928605
    Consensus CDS
    CCDS18326.1
    UniProtKB/Swiss-Prot
    P01573, Q61717
    UniProtKB/TrEMBL
    B1AYH7
    Related
    ENSMUSP00000100778.2, ENSMUST00000105147.2
    Conserved Domains (1) summary
    pfam00143
    Location:26185
    Interferon; Interferon alpha/beta domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    88601444..88602016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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