U.S. flag

An official website of the United States government

CYP26A1 cytochrome P450 family 26 subfamily A member 1 [ Homo sapiens (human) ]

Gene ID: 1592, updated on 4-Jan-2025

Summary

Official Symbol
CYP26A1provided by HGNC
Official Full Name
cytochrome P450 family 26 subfamily A member 1provided by HGNC
Primary source
HGNC:HGNC:2603
See related
Ensembl:ENSG00000095596 MIM:602239; AllianceGenome:HGNC:2603
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CP26; CYP26; P450RAI; P450RAI1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues. Two alternatively spliced transcript variants of this gene, which encode the distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 15.5) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CYP26A1 in Genome Data Viewer
Location:
10q23.33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (93073475..93077885)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (93953370..93957780)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (94833232..94837642)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2626 Neighboring gene exocyst complex component 6 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:94652149-94652648 Neighboring gene NANOG hESC enhancer GRCh37_chr10:94653981-94654616 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:94667799-94667959 Neighboring gene Sharpr-MPRA regulatory region 15544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3780 Neighboring gene Sharpr-MPRA regulatory region 5548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:94820573-94821482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3782 Neighboring gene cytochrome P450 family 26 subfamily C member 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:94856294-94857150 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:94857151-94858007 Neighboring gene Sharpr-MPRA regulatory region 10607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3783 Neighboring gene Sharpr-MPRA regulatory region 3565 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3785 Neighboring gene NIP7 pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:94897634-94898833 Neighboring gene Sharpr-MPRA regulatory region 1522 Neighboring gene X-ray repair cross complementing 6 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
EBI GWAS Catalog
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in endoplasmic reticulum membrane  

General protein information

Preferred Names
cytochrome P450 26A1
Names
P450, retinoic acid-inactivating, 1
cytochrome P450 retinoic acid-inactivating 1
cytochrome P450, family 26, subfamily A, polypeptide 1
cytochrome P450, subfamily XXVIA, polypeptide 1
cytochrome P450RAI
hP450RAI
retinoic acid 4-hydroxylase
retinoic acid-metabolizing cytochrome
NP_000774.2
NP_476498.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008067.1 RefSeqGene

    Range
    5419..9411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000783.4NP_000774.2  cytochrome P450 26A1 isoform 1

    See identical proteins and their annotated locations for NP_000774.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (1).
    Source sequence(s)
    AL358613
    Consensus CDS
    CCDS7426.1
    UniProtKB/Swiss-Prot
    B3KNI4, O43174, Q5VXH9, Q5VXI0
    Related
    ENSP00000224356.4, ENST00000224356.5
    Conserved Domains (1) summary
    cl12078
    Location:14492
    p450; Cytochrome P450
  2. NM_057157.2NP_476498.1  cytochrome P450 26A1 isoform 2

    See identical proteins and their annotated locations for NP_476498.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' end region, which doesn't contain an in-frame translation start codon, when compared to variant 1. Translation thus begins at a downstream start codon, and results in a N-terminal truncated protein, as compared to isoform 1.
    Source sequence(s)
    AL358613
    Consensus CDS
    CCDS7427.1
    UniProtKB/Swiss-Prot
    O43174
    Related
    ENSP00000360586.1, ENST00000371531.5
    Conserved Domains (1) summary
    cl12078
    Location:4422
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    93073475..93077885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    93953370..93957780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.