Id3 inhibitor of DNA binding 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Id3provided by MGI
Official Full Name: inhibitor of DNA binding 3provided by MGI
Primary source: MGI:MGI:96398
See related: Ensembl:ENSMUSG00000007872 AllianceGenome:MGI:96398
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Idb3; Hlh462; bHLHb25
Summary: Enables leptomycin B binding activity; protein domain specific binding activity; and transcription regulator inhibitor activity. Involved in negative regulation of myoblast differentiation; negative regulation of transcription, DNA-templated; and positive regulation of gene expression. Acts upstream of or within several processes, including animal organ development; cellular response to leptomycin B; and negative regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; limb; metanephros; and sensory organ. Used to study Sjogren's syndrome. Orthologous to human ID3 (inhibitor of DNA binding 3, HLH protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 274.3), stomach adult (RPKM 262.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 68.34 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (135871133..135872703)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (136143822..136145392)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The nuclear factor ID3 endows macrophages with a potent anti-tumour activity.
Title: The nuclear factor ID3 endows macrophages with a potent anti-tumour activity.
Investigating the ID3/SLC22A4 as immune-related signatures in ischemic stroke.
Title: Investigating the ID3/SLC22A4 as immune-related signatures in ischemic stroke.
Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1-mediated immune suppression during GVHD.
Title: Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1-mediated immune suppression during GVHD.
Id3 expression identifies CD4(+) memory Th1 cells.
Title: Id3 expression identifies CD4(+) memory Th1 cells.
Loss of Id3 (Inhibitor of Differentiation 3) Increases the Number of IgM-Producing B-1b Cells in Ischemic Skeletal Muscle Impairing Blood Flow Recovery During Hindlimb Ischemia.
Title: Loss of Id3 (Inhibitor of Differentiation 3) Increases the Number of IgM-Producing B-1b Cells in Ischemic Skeletal Muscle Impairing Blood Flow Recovery During Hindlimb Ischemia.
ID1 and ID3 are Negative Regulators of TGFbeta2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice.
Title: ID1 and ID3 are Negative Regulators of TGFβ2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice.
Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation.
Title: Helix-Loop-Helix Factor Id3 (Inhibitor of Differentiation 3): A Novel Regulator of Hyaluronan-Mediated Adipose Tissue Inflammation.
Interleukin-21-mediated suppression of the Pax3-Id3 pathway exacerbates the development of Sjogren's syndrome via follicular helper T cells.
Title: Interleukin-21-mediated suppression of the Pax3-Id3 pathway exacerbates the development of Sjögren's syndrome via follicular helper T cells.
Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
Title: Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
Idgenes are required for morphogenesis and cellular patterning in the developing mammalian cochlea.
Title: Idgenes are required for morphogenesis and cellular patterning in the developing mammalian cochlea.

Submit: New GeneRIF Correction See all GeneRIFs (88)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Id3 (e-PCR)
- UniSTS:471309

Id3 (e-PCR)
- UniSTS:547642

UniSTS:235067 (e-PCR)
- UniSTS:235067

Id3 (e-PCR)
- UniSTS:528221

PMC133998P6 (e-PCR)
- UniSTS:270711

Id3 (e-PCR)
- UniSTS:545950

Id3 (e-PCR)
- UniSTS:256941

UniSTS:256941 (e-PCR)
- UniSTS:256941

PMC305683P3 (e-PCR)
- UniSTS:272559

Idb3 (e-PCR), detects polymorphism
- UniSTS:256474

MARC_5735-5736:996690763:1 (e-PCR)
- UniSTS:269553

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bHLH transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables leptomycin B binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription regulator inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to leptomycin B	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within epithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in metanephros development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of osteoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in notochord development	IEP Inferred from Expression Pattern more info	PubMed
involved_in odontogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: DNA-binding protein inhibitor ID-3

Names: ID-like protein inhibitor HLH 462; inhibitor of differentiation 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429353.1 → NP_001416282.1 DNA-binding protein inhibitor ID-3

Status: VALIDATED

Source sequence(s)

AL935264
NM_008321.3 → NP_032347.1 DNA-binding protein inhibitor ID-3

See identical proteins and their annotated locations for NP_032347.1

Status: VALIDATED

Source sequence(s)

AL935264

Consensus CDS

CCDS18800.1

UniProtKB/Swiss-Prot

P41133

UniProtKB/TrEMBL

Q545W1

Related

ENSMUSP00000008016.3, ENSMUST00000008016.3

Conserved Domains (1) summary

cd19693
Location:23 → 83

bHLH_dnHLH_ID3; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID3 and similar proteins