Id1 inhibitor of DNA binding 1, HLH protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Id1provided by MGI
Official Full Name: inhibitor of DNA binding 1, HLH proteinprovided by MGI
Primary source: MGI:MGI:96396
See related: Ensembl:ENSMUSG00000042745 AllianceGenome:MGI:96396
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Idb1; bHLHb24; D2Wsu140e
Summary: Enables protein self-association and transcription regulator inhibitor activity. Involved in negative regulation of cold-induced thermogenesis; negative regulation of transcription, DNA-templated; and positive regulation of gene expression. Acts upstream of or within several processes, including endothelial cell morphogenesis; lung development; and negative regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human ID1 (inhibitor of DNA binding 1, HLH protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in stomach adult (RPKM 416.7), colon adult (RPKM 399.7) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 75.41 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (152578171..152579330)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (152736251..152737410)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment.
Title: The non-cell-autonomous function of ID1 promotes AML progression via ANGPTL7 from the microenvironment.
Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma.
Title: Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma.
ID1 and CEBPA coordinate epidermal progenitor cell differentiation.
Title: ID1 and CEBPA coordinate epidermal progenitor cell differentiation.
ID1 marks the tumorigenesis of pancreatic ductal adenocarcinoma in mouse and human.
Title: ID1 marks the tumorigenesis of pancreatic ductal adenocarcinoma in mouse and human.
Ursodesoxycholic acid alleviates liver fibrosis via proregeneration by activation of the ID1-WNT2/HGF signaling pathway.
Title: Ursodesoxycholic acid alleviates liver fibrosis via proregeneration by activation of the ID1-WNT2/HGF signaling pathway.
Id1 expression in kidney endothelial cells protects against diabetes-induced microvascular injury.
Title: Id1 expression in kidney endothelial cells protects against diabetes-induced microvascular injury.
ID1 and ID3 are Negative Regulators of TGFbeta2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice.
Title: ID1 and ID3 are Negative Regulators of TGFβ2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice.
FOXC1 negatively regulates BMP-SMAD activity and Id1 expression during osteoblast differentiation.
Title: FOXC1 negatively regulates BMP-SMAD activity and Id1 expression during osteoblast differentiation.
Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
Title: Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
ID1-Mediated BMP Signaling Pathway Potentiates Glucagon-Like Peptide-1 Secretion in Response to Nutrient Replenishment.
Title: ID1-Mediated BMP Signaling Pathway Potentiates Glucagon-Like Peptide-1 Secretion in Response to Nutrient Replenishment.

Submit: New GeneRIF Correction See all GeneRIFs (114)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC33181P1 (e-PCR)
- UniSTS:273154

PMC156147P2 (e-PCR)
- UniSTS:271379

D2Wsu140e (e-PCR), detects polymorphism
- UniSTS:142372

AA407767 (e-PCR)
- UniSTS:178735

Id1 (e-PCR), detects polymorphism
- UniSTS:547640

Idb1 (e-PCR), detects polymorphism
- UniSTS:238137

Idb1 (e-PCR), detects polymorphism
- UniSTS:143448

PMC133998P5 (e-PCR)
- UniSTS:270710

PMC145454P1 (e-PCR)
- UniSTS:271000

PMC145454P3 (e-PCR)
- UniSTS:271002

Idb1 (e-PCR), detects polymorphism
- UniSTS:256938

PMC305683P1 (e-PCR)
- UniSTS:272557

Idb1 (e-PCR), detects polymorphism
- UniSTS:256472

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables proteasome binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription regulator inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription regulator inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within collagen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of endothelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endothelial cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of endothelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of osteoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein destabilization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein destabilization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to antibiotic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA-binding protein inhibitor ID-1

Names: inhibitor of differentiation 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355113.1 → NP_001342042.1 DNA-binding protein inhibitor ID-1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses a splice site in the 3' region, compared to variant 3. This results in a shorter protein (isoform 1), compared to isoform 3.

Source sequence(s)

AL731857, AV588021

UniProtKB/Swiss-Prot

P20067, Q61101, Q9D897

Conserved Domains (1) summary

cd00083
Location:61 → 102

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_001369018.1 → NP_001355947.1 DNA-binding protein inhibitor ID-1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes the longest isoform (3).

Source sequence(s)

AL731857

Consensus CDS

CCDS89567.1

UniProtKB/Swiss-Prot

P20067, Q61101, Q9D897

UniProtKB/TrEMBL

A2AHY3

Related

ENSMUSP00000105449.2, ENSMUST00000109824.2

Conserved Domains (1) summary

cd00083
Location:61 → 102

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
NM_010495.3 → NP_034625.1 DNA-binding protein inhibitor ID-1 isoform 2

See identical proteins and their annotated locations for NP_034625.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a splice site in the 3' region, compared to variant 3. This results in a shorter protein (isoform 2), compared to isoform 3.

Source sequence(s)

AL731857

Consensus CDS

CCDS16897.1

UniProtKB/Swiss-Prot

P20067, Q61101, Q9D897

UniProtKB/TrEMBL

Q6GTZ3

Related

ENSMUSP00000092019.5, ENSMUST00000038368.9

Conserved Domains (1) summary

cd00083
Location:61 → 102

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...