U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Icam1 intercellular adhesion molecule 1 [ Mus musculus (house mouse) ]

Gene ID: 15894, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Icam1provided by MGI
Official Full Name
intercellular adhesion molecule 1provided by MGI
Primary source
MGI:MGI:96392
See related
Ensembl:ENSMUSG00000037405 AllianceGenome:MGI:96392
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD54; Ly-47; Icam-1; MALA-2
Summary
This gene encodes an integral membrane protein that binds leukocyte adhesion protein LFA-1. It participates in the innate immune response. [provided by RefSeq, Aug 2016]
Expression
Biased expression in lung adult (RPKM 157.0), spleen adult (RPKM 29.7) and 6 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 A3; 9 7.69 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20927236..20940110)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21015940..21028814)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate receptor 2 Neighboring gene STARR-seq mESC enhancer starr_23470 Neighboring gene STARR-seq mESC enhancer starr_23474 Neighboring gene mitochondrial ribosomal protein L4 Neighboring gene STARR-seq mESC enhancer starr_23475 Neighboring gene STARR-seq mESC enhancer starr_23476 Neighboring gene STARR-positive B cell enhancer ABC_E569 Neighboring gene intercellular adhesion molecule 4, Landsteiner-Wiener blood group Neighboring gene microRNA 1900 Neighboring gene intercellular adhesion molecule 5, telencephalin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ICAM-1 on Breast Cancer Cells Suppresses Lung Metastasis but Is Dispensable for Tumor Growth and Killing by Cytotoxic T Cells. Regev O, et al. Front Immunol, 2022. PMID 35911772, Free PMC Article
  2. Intercellular Adhesion Molecule-1 Enhances Myonuclear Transcription during Injury-Induced Muscle Regeneration. Buckley KH, et al. Int J Mol Sci, 2022 Jun 24. PMID 35806032, Free PMC Article
  3. Oligodendrocytes regulate the adhesion molecule ICAM-1 in neuroinflammation. González-Alvarado MN, et al. Glia, 2022 Mar. PMID 34787332
  4. Immunotherapy with a biologically active ICAM-1 mAb and an siRNA targeting TSHR in a BALB/c mouse model of Graves' disease. Wang X, et al. Endokrynol Pol, 2021. PMID 34647608
  5. Intercellular Adhesion Molecule-1-Induced Posttraumatic Brain Injury Neuropathology in the Prefrontal Cortex and Hippocampus Leads to Sensorimotor Function Deficits and Psychological Stress. Bhowmick S, et al. eNeuro, 2021 Jul-Aug. PMID 34135004, Free PMC Article

See all (597) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PGRN inhibits CD8[+]T cell recruitment and promotes breast cancer progression by up-regulating ICAM-1 on TAM.
    Title: PGRN inhibits CD8(+)T cell recruitment and promotes breast cancer progression by up-regulating ICAM-1 on TAM.
  2. Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma.
    Title: Age-dependent loss of HAPLN1 erodes vascular integrity via indirect upregulation of endothelial ICAM1 in melanoma.
  3. ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.
    Title: ICAM-1 Deletion Using CRISPR/Cas9 Protects the Brain from Traumatic Brain Injury-Induced Inflammatory Leukocyte Adhesion and Transmigration Cascades by Attenuating the Paxillin/FAK-Dependent Rho GTPase Pathway.
  4. Intermittent hypoxia increased the expression of ESM1 and ICAM-1 in vascular endothelial cells via the downregulation of microRNA-181a1.
    Title: Intermittent hypoxia increased the expression of ESM1 and ICAM-1 in vascular endothelial cells via the downregulation of microRNA-181a1.
  5. ICAM-1 Abundance Is Increased in Pancreatic Islets of Hyperglycemic Female NOD Mice and Is Rapidly Upregulated by NF-kappaB in Pancreatic beta-Cells.
    Title: ICAM-1 Abundance Is Increased in Pancreatic Islets of Hyperglycemic Female NOD Mice and Is Rapidly Upregulated by NF-κB in Pancreatic β-Cells.
  6. TIAM2S-positive microglia enhance inflammation and neurotoxicity through soluble ICAM-1-mediated immune priming.
    Title: TIAM2S-positive microglia enhance inflammation and neurotoxicity through soluble ICAM-1-mediated immune priming.
  7. LFA-1/ICAM-1 Adhesion Pathway Mediates the Homeostatic Migration of Lymphocytes from Peripheral Tissues into Lymph Nodes through Lymphatic Vessels.
    Title: LFA-1/ICAM-1 Adhesion Pathway Mediates the Homeostatic Migration of Lymphocytes from Peripheral Tissues into Lymph Nodes through Lymphatic Vessels.
  8. Induction of ICAM1 in Brain Vessels is Implicated in an Early AD Pathogenesis by Modulating Neprilysin.
    Title: Induction of ICAM1 in Brain Vessels is Implicated in an Early AD Pathogenesis by Modulating Neprilysin.
  9. ERbeta promoted invadopodia formation-mediated non-small cell lung cancer metastasis via the ICAM1/p-Src/p-Cortactin signaling pathway.
    Title: ERβ promoted invadopodia formation-mediated non-small cell lung cancer metastasis via the ICAM1/p-Src/p-Cortactin signaling pathway.
  10. A YAP/TAZ-CD54 axis is required for CXCR2-CD44- tumor-specific neutrophils to suppress gastric cancer.
    Title: A YAP/TAZ-CD54 axis is required for CXCR2-CD44- tumor-specific neutrophils to suppress gastric cancer.
Submit: New GeneRIF Correction See all GeneRIFs (246)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC6195

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within T cell antigen processing and presentation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within T cell extravasation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in acute inflammatory response to antigenic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in adhesion of symbiont to host ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in establishment of Sertoli cell barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of endothelial intestinal barrier ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cellular extravasation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor-mediated virion attachment to host cell ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of ruffle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in immunological synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
intercellular adhesion molecule 1
Names
myD10

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010493.3 → NP_034623.1  intercellular adhesion molecule 1 precursor

    See identical proteins and their annotated locations for NP_034623.1

    Status: REVIEWED

    Source sequence(s)
    AK151681, AW491621, BY777078
    Consensus CDS
    CCDS22889.1
    UniProtKB/Swiss-Prot
    P13597, Q61828
    UniProtKB/TrEMBL
    Q3U7Q9, Q3U8M7, Q3UDJ5, Q3UE52, Q4FK06
    Related
    ENSMUSP00000083587.5, ENSMUST00000086399.6
    Conserved Domains (4) summary
    cd05755
    Location:112 → 206
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    smart00410
    Location:408 → 478
    IG_like; Immunoglobulin like
    pfam03921
    Location:24 → 109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cl11960
    Location:313 → 391
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    20927236..20940110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13597.1 GenPept UniProtKB/Swiss-Prot:P13597

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous