Ibsp integrin binding sialoprotein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ibspprovided by MGI
Official Full Name: integrin binding sialoproteinprovided by MGI
Primary source: MGI:MGI:96389
See related: Ensembl:ENSMUSG00000029306 AllianceGenome:MGI:96389
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BSP; Bsp2; BSPII; BSP II
Summary: Predicted to enable integrin binding activity. Acts upstream of or within bone mineralization; cellular response to growth factor stimulus; and extracellular matrix organization. Predicted to be located in extracellular space and vesicle. Is expressed in several structures, including axial skeleton; bone; facial prominence; jaw; and limb. Orthologous to human IBSP (integrin binding sialoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in limb E14.5 (RPKM 37.3), CNS E14 (RPKM 11.6) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E5; 5 50.68 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (104447153..104459338)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (104299287..104311472)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockout of bone sialoprotein in cementoblasts cell lines affects specific gene expression in unstimulated and mechanically stimulated conditions.
Title: Knockout of bone sialoprotein in cementoblasts cell lines affects specific gene expression in unstimulated and mechanically stimulated conditions.
The Bone Sialoprotein RGD Domain Modulates and Maintains Periodontal Development.
Title: The Bone Sialoprotein RGD Domain Modulates and Maintains Periodontal Development.
Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer.
Title: Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer.
Tb4 induced BSP expression in MDPC23 cells via ERK and Smad3 signaling pathways, suggesting its role as a signaling molecule in odontoblasts for regulating BSP secretion during dentinogenesis.
Title: Thymosin β4 is associated with bone sialoprotein expression via ERK and Smad3 signaling pathways in MDPC-23 odontoblastic cells.
Data indicate that BSP is present in the calcified fibrocartilage of murine entheses and suggest that BSP plays a regulatory role in this structure, influencing the growth of the calcified fibrocartilage in addition to the weakening of the tendon mechanical properties.
Title: The role of bone sialoprotein in the tendon-bone insertion.
Bone marrow ablation in BSP-/- mice is followed by a faster vascular and hematopoietic recolonization, along with lower medullary bone formation. Thus, lack of BSP affects the interplay between hematopoiesis, angiogenesis, and osteogenesis, maybe in part through higher expression of VEGF and the angiogenic SIBLING, OPN.
Title: Bone Shaft Revascularization After Marrow Ablation Is Dramatically Accelerated in BSP-/- Mice, Along With Faster Hematopoietic Recolonization.
a bone sialoprotein-null bone microenvironment affects the hematopoietic system both quantitatively and qualitatively
Title: Absence of bone sialoprotein (BSP) alters profoundly hematopoiesis and upregulates osteopontin.
full expression of either OPN or BSP is necessary for the anabolic effect of PTH at least in the ectopic calvaria injection model
Title: Blocking the expression of both bone sialoprotein (BSP) and osteopontin (OPN) impairs the anabolic action of PTH in mouse calvaria bone.
BSP plays a non-redundant role in acellular cementum formation, likely involved in initiating mineralization on the root surface. Through its importance to cementum integrity, BSP is essential for periodontal function.
Title: Deficiency in acellular cementum and periodontal attachment in bsp null mice.
Lack of BSP affects both osteoclast formation and activity.
Title: Bone sialoprotein deficiency impairs osteoclastogenesis and mineral resorption in vitro.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

L23801 (e-PCR)
- UniSTS:163365

Ibsp (e-PCR), detects polymorphism
- UniSTS:498473

L23801 (e-PCR)
- UniSTS:124882

Ibsp (e-PCR), detects polymorphism
- UniSTS:498387

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables small molecule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within biomineral tissue development	IEA Inferred from Electronic Annotation more info
involved_in bone mineralization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	IDA Inferred from Direct Assay more info	PubMed
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin-binding sialoprotein

Names: bone sialoprotein 2; bone sialoprotein II; cell-binding sialoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.