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CYP2J2 cytochrome P450 family 2 subfamily J member 2 [ Homo sapiens (human) ]

Gene ID: 1573, updated on 5-Mar-2024

Summary

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Official Symbol
CYP2J2provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily J member 2provided by HGNC
Primary source
HGNC:HGNC:2634
See related
Ensembl:ENSG00000134716 MIM:601258; AllianceGenome:HGNC:2634
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPJ2; CYPIIJ2
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
Expression
Biased expression in small intestine (RPKM 44.5), heart (RPKM 35.2) and 10 other tissues See more
Orthologs
all
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Genomic context

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Location:
1p32.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (59893308..59969212, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (59771763..59847665, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (60358980..60392445, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378758 Neighboring gene uncharacterized LOC101926944 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 943 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:60280925-60281488 Neighboring gene hook microtubule tethering protein 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:60380537-60381736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:60391793-60392328 Neighboring gene RNA, 7SL, cytoplasmic 475, pseudogene Neighboring gene chromosome 1 open reading frame 87 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:60505410-60506609

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma. Zou X, et al. Biomed Res Int, 2021. PMID 34258261, Free PMC Article
  2. Molecular determinant of substrate binding and specificity of cytochrome P450 2J2. Xu L, et al. Sci Rep, 2020 Dec 17. PMID 33335233, Free PMC Article
  3. Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population. Lu H, et al. Arch Bronconeumol (Engl Ed), 2020 Nov. PMID 32224017
  4. CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes. Evangelista EA, et al. Sci Rep, 2020 Mar 24. PMID 32210298, Free PMC Article
  5. Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case-control study. Hayran Y, et al. An Bras Dermatol, 2020 Jan-Feb. PMID 31902555, Free PMC Article

See all (136) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage.
    Title: CYP2C8 and CYP2J2 gene variations increase the risk of hypertensive intracerebral hemorrhage.
  2. Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation.
    Title: Endothelial CYP2J2 overexpression restores the BRB via METTL3-mediated ANXA1 upregulation.
  3. CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro.
    Title: CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro.
  4. CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma.
    Title: CYP2J2 Is a Diagnostic and Prognostic Biomarker Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma.
  5. 6,8-Diprenylorobol Induces Apoptosis in Human Hepatocellular Carcinoma Cells via Activation of FOXO3 and Inhibition of CYP2J2.
    Title: 6,8-Diprenylorobol Induces Apoptosis in Human Hepatocellular Carcinoma Cells via Activation of FOXO3 and Inhibition of CYP2J2.
  6. Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population.
    Title: Influence of the CYP2J2 Gene Polymorphisms on Chronic Obstructive Pulmonary Disease Risk in the Chinese Han Population.
  7. Molecular determinant of substrate binding and specificity of cytochrome P450 2J2.
    Title: Molecular determinant of substrate binding and specificity of cytochrome P450 2J2.
  8. CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes.
    Title: CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes.
  9. In conclusion, the rs2280275 and rs11572325 SNPs of CYP2J2 may be considered novel genetic markers of hypertension, at least in Russian women
    Title: A comprehensive study revealed SNP-SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension risk.
  10. CYP2J2 50G>T (rs890293) polymorphism was associated with an increased risk for psoriasis in the Turkish population
    Title: Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case-control study.
Submit: New GeneRIF Correction See all GeneRIFs (106)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables arachidonic acid 11,12-epoxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arachidonic acid 14,15-epoxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arachidonic acid 5,6-epoxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables arachidonic acid epoxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arachidonic acid epoxygenase activity TAS
Traceable Author Statement
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroperoxy icosatetraenoate isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables linoleic acid epoxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monooxygenase activity TAS
Traceable Author Statement
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in epoxygenase P450 pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in epoxygenase P450 pathway TAS
Traceable Author Statement
more info
  
involved_in fatty acid metabolic process TAS
Traceable Author Statement
more info
  
involved_in icosanoid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in linoleic acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of heart contraction TAS
Traceable Author Statement
more info
 PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic metabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome P450 2J2
Names
albendazole monooxygenase (hydroxylating)
albendazole monooxygenase (sulfoxide-forming)
arachidonic acid epoxygenase
cytochrome P450, family 2, subfamily J, polypeptide 2
cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) polypeptide 2
flavoprotein-linked monooxygenase
hydroperoxy icosatetraenoate isomerase
microsomal monooxygenase
NP_000766.2
XP_047303454.1
XP_047303455.1
XP_054190678.1
XP_054190679.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007931.2 RefSeqGene

    Range
    47439..80904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000775.4 → NP_000766.2  cytochrome P450 2J2

    See identical proteins and their annotated locations for NP_000766.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the protein-coding transcript.
    Source sequence(s)
    BC032594
    Consensus CDS
    CCDS613.1
    UniProtKB/Swiss-Prot
    B2RD33, P51589, Q8TF13
    Related
    ENSP00000360247.3, ENST00000371204.4
    Conserved Domains (1) summary
    pfam00067
    Location:44 → 497
    p450; Cytochrome P450

RNA

  1. NR_134981.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC032594, CD013972
    Related
    ENST00000466095.5

  2. NR_134982.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC113175, BC032594, CD013973
    Related
    ENST00000468257.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    59893308..59969212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447499.1 → XP_047303455.1  cytochrome P450 2J2 isoform X1

  2. XM_047447498.1 → XP_047303454.1  cytochrome P450 2J2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    59771763..59847665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334704.1 → XP_054190679.1  cytochrome P450 2J2 isoform X1

  2. XM_054334703.1 → XP_054190678.1  cytochrome P450 2J2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51589.2 GenPept UniProtKB/Swiss-Prot:P51589

Gene LinkOut

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