Tnfrsf1b TNF receptor superfamily member 1B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnfrsf1bprovided by RGD
Official Full Name: TNF receptor superfamily member 1Bprovided by RGD
Primary source: RGD:621238
See related: Ensembl:ENSRNOG00000016575 AllianceGenome:RGD:621238
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tnfr2
Summary: Enables tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to tumor necrosis factor; and response to lipopolysaccharide. Located in several cellular components, including neuronal cell body; perinuclear region of cytoplasm; and varicosity. Used to study visual epilepsy. Biomarker of Crohn's disease; myocardial infarction; sciatic neuropathy; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to human TNFRSF1B (TNF receptor superfamily member 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 212.2), Lung (RPKM 137.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (162356250..162387411, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (157070642..157104216, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (163136390..163167299, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cardiac inflammatory CD11b/c cells exert a protective role in hypertrophied cardiomyocyte by promoting TNFR2- and Orai3- dependent signaling.
Title: Cardiac inflammatory CD11b/c cells exert a protective role in hypertrophied cardiomyocyte by promoting TNFR(2)- and Orai3- dependent signaling.
results suggested that PTE may promote BMSC proliferation and osteogenic differentiation via a mechanism associated with the regulation of Let-7f-5p and the TNFR2/PI3K/AKT signaling pathway.
Title: Plastrum Testudinis Extracts Promote BMSC Proliferation and Osteogenic Differentiation by Regulating Let-7f-5p and the TNFR2/PI3K/AKT Signaling Pathway.
TNF plays an inhibitory role in modulating myocardial SDF-1 production and blockade of TNF signaling by ablation of TNFR1 and TNFR2 genes increased SDF-1 expression in the heart. These data expand on TNF signaling-initiated mechanisms in myocardium, which may lend a more complete understanding of SDF-1 and TNFR-derived actions in hopes of advancing ischemic heart injury treatments.
Title: Regulation of myocardial stromal cell-derived factor 1α/CXCL12 by tumor necrosis factor signaling.
Curcumin decreased TNFR2 and increased TRAF2 to decrease the apoptotic pathway in ureteral obstruction rats.
Title: Effect of curcumin on TNFR2 and TRAF2 in unilateral ureteral obstruction in rats.
TNFR1 and TNFR2 regulate voltage-gated sodium channels in rat dorsal root ganglia
Title: Modulation of Voltage-Gated Sodium Channels by Activation of Tumor Necrosis Factor Receptor-1 and Receptor-2 in Small DRG Neurons of Rats.
The IL-17RD.TNFR2 complex in activation of NF-kappaB may explain the role of TNFR2 in inflammatory diseases including nephritis.
Title: Tumor necrosis factor receptor 2 (TNFR2)·interleukin-17 receptor D (IL-17RD) heteromerization reveals a novel mechanism for NF-κB activation.
Ozone suppresses joint swelling in rheumatoid arthrtis by down-regulating synovial TNF-alpha and TNF-R2 and up-regulating TNF-R1 in the joint.
Title: The effect of intra-articular injection of different concentrations of ozone on the level of TNF-α, TNF-R1, and TNF-R2 in rats with rheumatoid arthritis.
the microglial TNF-alpha p55 pathway played a more important role than the TNF-alpha p75 pathway in the pathogenesis of peripheral nerve injury pain.
Title: Differences between tumor necrosis factor-α receptors types 1 and 2 in the modulation of spinal glial cell activation and mechanical allodynia in a rat sciatic nerve injury model.
Intra-articular injection of ozone can attenuate synovitis in rats with rheumatoid arthritis, which may involve the inhibition of TNF-alpha and TNFR II activity and enhancement of TNFR I activity in the synovium.
Title: [Effect of intra-articular ozone injection on serum and synovial TNF-α, TNFR I, and TNFR II contents in rats with rheumatoid arthritis].
The moxibustion therapies could reduce intestinal inflammation and restore intestinal epithelium barrier disruption in CD, which might be due to down-regulating TNF-alpha, TNFR1, and TNFR2 in intestinal mucosa and improving intestinal epithelium morphology.
Title: Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn's disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables tumor necrosis factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables tumor necrosis factor receptor activity	IEA Inferred from Electronic Annotation more info
enables tumor necrosis factor receptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA destabilization	ISO Inferred from Sequence Orthology more info
involved_in aortic valve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in glial cell-neuron signaling	ISO Inferred from Sequence Orthology more info
involved_in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extracellular matrix constituent secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuroinflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process involved in morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myelination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve development	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell cytokine production	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of T cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuroinflammatory response	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in varicosity	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 1B

Names: TNF-R2; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily, member 1b; tumor necrosis factor receptor type II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130426.4 → NP_569110.1 tumor necrosis factor receptor superfamily member 1B precursor

See identical proteins and their annotated locations for NP_569110.1

Status: PROVISIONAL

Source sequence(s)

AF498039

UniProtKB/Swiss-Prot

Q5YLP0, Q80WY6

UniProtKB/TrEMBL

A0A8I5ZLM8, A6IU15

Related

ENSRNOP00000022478.3, ENSRNOT00000022478.5

Conserved Domains (1) summary

cd10577
Location:40 → 203

TNFRSF1B; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2