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Htr5b 5-hydroxytryptamine (serotonin) receptor 5B [ Mus musculus (house mouse) ]

Gene ID: 15564, updated on 2-May-2024

Summary

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Official Symbol
Htr5bprovided by MGI
Official Full Name
5-hydroxytryptamine (serotonin) receptor 5Bprovided by MGI
Primary source
MGI:MGI:96284
See related
Ensembl:ENSMUSG00000050534 AllianceGenome:MGI:96284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5-Ht5b
Summary
Enables G protein-coupled serotonin receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and chemical synaptic transmission. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adrenal gland; central nervous system; eye; incisor; and male reproductive gland or organ. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 3.1), genital fat pad adult (RPKM 0.7) and 4 other tissues See more
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Genomic context

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Location:
1 E2.3; 1 52.98 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (121437487..121458351, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (121509758..121529312, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10030 Neighboring gene predicted gene, 35243 Neighboring gene coiled-coil domain containing 93 Neighboring gene STARR-seq mESC enhancer starr_02076 Neighboring gene STARR-seq mESC enhancer starr_02077 Neighboring gene DEAD box helicase 18 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:123504681-123504864 Neighboring gene STARR-seq mESC enhancer starr_02078 Neighboring gene STARR-seq mESC enhancer starr_02080 Neighboring gene STARR-seq mESC enhancer starr_02081 Neighboring gene STARR-seq mESC enhancer starr_02082 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 10 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-directed behavior. Yoshida K, et al. Nat Neurosci, 2019 May. PMID 30988523
  2. Chemical Landscape for Tissue Clearing Based on Hydrophilic Reagents. Tainaka K, et al. Cell Rep, 2018 Aug 21. PMID 30134179
  3. Persistent Expression of Serotonin Receptor 5b Alters Breathing Behavior in Male MeCP2 Knockout Mice. Vogelgesang S, et al. Front Mol Neurosci, 2018. PMID 29515365, Free PMC Article
  4. Optogenetic activation of CA1 pyramidal neurons at the dorsal and ventral hippocampus evokes distinct brain-wide responses revealed by mouse fMRI. Takata N, et al. PLoS One, 2015. PMID 25793741, Free PMC Article
  5. Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene. Maekawa T, et al. EMBO J, 2010 Jan 6. PMID 19893493, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atf-7-deficient mice exhibit abnormal behaviours and increased 5-HT receptor 5B (Htr5b) mRNA levels in the dorsal raphe nuclei.
    Title: Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC141198

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled serotonin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
5-hydroxytryptamine receptor 5B
Names
5-HT-5B
protein-tyrosine-phosphatase (EC 3.1.3.48) Ly-5 precursor (B-cell variant)
serotonin receptor 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010483.3 → NP_034613.2  5-hydroxytryptamine receptor 5B

    See identical proteins and their annotated locations for NP_034613.2

    Status: VALIDATED

    Source sequence(s)
    AC111011
    Consensus CDS
    CCDS15239.1
    UniProtKB/Swiss-Prot
    P31387, Q1RME2
    UniProtKB/TrEMBL
    G3X9C6
    Related
    ENSMUSP00000057212.8, ENSMUST00000055884.8
    Conserved Domains (1) summary
    pfam00001
    Location:69 → 351
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    121437487..121458351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317180.2 → XP_017172669.1  5-hydroxytryptamine receptor 5B isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:87 → 113
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:65 → 241
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31387.1 GenPept UniProtKB/Swiss-Prot:P31387

Gene LinkOut

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