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Htr1d 5-hydroxytryptamine (serotonin) receptor 1D [ Mus musculus (house mouse) ]

Gene ID: 15552, updated on 11-Apr-2024

Summary

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Official Symbol
Htr1dprovided by MGI
Official Full Name
5-hydroxytryptamine (serotonin) receptor 1Dprovided by MGI
Primary source
MGI:MGI:96276
See related
Ensembl:ENSMUSG00000070687 AllianceGenome:MGI:96276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5-HT1D; Gpcr14; Htr1db; 5-HT-1D
Summary
Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Acts upstream of or within response to toxic substance. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and integumental system. Orthologous to human HTR1D (5-hydroxytryptamine receptor 1D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 1.0), bladder adult (RPKM 0.8) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 68.74 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136150835..136171716)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136423522..136444405)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein R Neighboring gene predicted gene, 54262 Neighboring gene predicted gene, 31295 Neighboring gene leucine zipper protein 1 Neighboring gene lysine (K)-specific demethylase 1A Neighboring gene STARR-positive B cell enhancer ABC_E6238 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene testis expressed 46

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Serotonin localization and its functional significance during mouse preimplantation embryo development. Il'ková G, et al. Zygote, 2004 Aug. PMID 15521710
  2. 5HT1Dbeta Receptor gene implicated in the pathogenesis of Obsessive-Compulsive Disorder: further evidence from a family-based association study. Mundo E, et al. Mol Psychiatry, 2002. PMID 12192628
  3. Immunolabeling of central serotonin 5-HT1D beta receptors in the rat, mouse, and guinea pig with a specific anti-peptide antiserum. Langlois X, et al. J Neurochem, 1995 Dec. PMID 7595565
  4. Sensorimotor function is modulated by the serotonin receptor 1d, a novel marker for gamma motor neurons. Enjin A, et al. Mol Cell Neurosci, 2012 Mar. PMID 22273508, Free PMC Article
  5. Serotonin type-1D receptor stimulation of A-type K(+) channel decreases membrane excitability through the protein kinase A- and B-Raf-dependent p38 MAPK pathways in mouse trigeminal ganglion neurons. Zhao X, et al. Cell Signal, 2016 Aug. PMID 27156838

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these results suggest that the activation of 5-HT1D receptors selectively enhanced IA via the Gbetagamma of the Go-protein, PKA, and the sequential B-Raf-dependent p38 MAPK signaling cascade.
    Title: Serotonin type-1D receptor stimulation of A-type K(+) channel decreases membrane excitability through the protein kinase A- and B-Raf-dependent p38 MAPK pathways in mouse trigeminal ganglion neurons.
  2. 5-hydroxytryptamine (serotonin) receptor 1D is a novel marker for gamma motor neurons and that the 5-ht1d receptor is important to receive and relay accurate sensory information in developing and mature spinal cord motor circuits.
    Title: Sensorimotor function is modulated by the serotonin receptor 1d, a novel marker for gamma motor neurons.
  3. presence of linkage disequilibrium between each of two polymorphisms of the 5HT1Dbeta receptor gene and obsessive-compulsive disorder
    Title: 5HT1Dbeta Receptor gene implicated in the pathogenesis of Obsessive-Compulsive Disorder: further evidence from a family-based association study.
  4. 5-HT2B and 1D autoreceptors may play a role in the maintenance of neuron- and neurotransmitter-associated functions.
    Title: Reactive oxygen species-dependent TNF-alpha converting enzyme activation through stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells.
  5. 5-Hydroxytryptamine(1B/1D) receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis.
    Title: 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis.
  6. PrPC is a modulator of 5-HT receptor coupling to G-proteins and contributes to the homeostasis of serotonergic neurons
    Title: Modulation of serotonergic receptor signaling and cross-talk by prion protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (2)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled serotonin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intestine smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of locomotion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to toxic substance IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in vasoconstriction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
5-hydroxytryptamine receptor 1D
Names
5-hydroxytryptamine (serotonin) receptor 1D beta
G-protein coupled receptor 14
serotonin receptor 1D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285482.1 → NP_001272411.1  5-hydroxytryptamine receptor 1D

    See identical proteins and their annotated locations for NP_001272411.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 all encode the same protein.
    Source sequence(s)
    AI853647, AK082016, AL670673, AW487918, BY728591
    Consensus CDS
    CCDS18806.1
    UniProtKB/Swiss-Prot
    Q3ZB48, Q61224, Q61615, Q8BUW7
    Related
    ENSMUSP00000112402.2, ENSMUST00000121571.8
    Conserved Domains (2) summary
    cd14964
    Location:38 → 62
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:32 → 364
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001285483.1 → NP_001272412.1  5-hydroxytryptamine receptor 1D

    See identical proteins and their annotated locations for NP_001272412.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.
    Source sequence(s)
    AI853647, AK082016, AL670673, AW487918
    Consensus CDS
    CCDS18806.1
    UniProtKB/Swiss-Prot
    Q3ZB48, Q61224, Q61615, Q8BUW7
    Related
    ENSMUSP00000112840.2, ENSMUST00000117699.2
    Conserved Domains (2) summary
    cd14964
    Location:38 → 62
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:32 → 364
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. NM_001285484.2 → NP_001272413.1  5-hydroxytryptamine receptor 1D

    See identical proteins and their annotated locations for NP_001272413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.
    Source sequence(s)
    AL670673
    Consensus CDS
    CCDS18806.1
    UniProtKB/Swiss-Prot
    Q3ZB48, Q61224, Q61615, Q8BUW7
    Conserved Domains (2) summary
    cd14964
    Location:38 → 62
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:32 → 364
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. NM_001421106.1 → NP_001408035.1  5-hydroxytryptamine receptor 1D

    Status: VALIDATED

    Source sequence(s)
    AL670673
    UniProtKB/Swiss-Prot
    Q3ZB48, Q61224, Q61615, Q8BUW7

  5. NM_001421107.1 → NP_001408036.1  5-hydroxytryptamine receptor 1D

    Status: VALIDATED

    Source sequence(s)
    AL670673
    UniProtKB/Swiss-Prot
    Q3ZB48, Q61224, Q61615, Q8BUW7

  6. NM_008309.5 → NP_032335.2  5-hydroxytryptamine receptor 1D

    See identical proteins and their annotated locations for NP_032335.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.
    Source sequence(s)
    AI853647, AK082016, AW487918, BY728591
    Consensus CDS
    CCDS18806.1
    UniProtKB/Swiss-Prot
    Q3ZB48, Q61224, Q61615, Q8BUW7
    Related
    ENSMUSP00000086052.5, ENSMUST00000088677.5
    Conserved Domains (2) summary
    cd14964
    Location:38 → 62
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:32 → 364
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    136150835..136171716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319986.3 → XP_017175475.1  5-hydroxytryptamine receptor 1D isoform X1

    UniProtKB/Swiss-Prot
    Q3ZB48, Q61224, Q61615, Q8BUW7
    Conserved Domains (2) summary
    cd14964
    Location:38 → 62
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:32 → 364
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61224.2 GenPept UniProtKB/Swiss-Prot:Q61224

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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