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Hrh1 histamine receptor H1 [ Mus musculus (house mouse) ]

Gene ID: 15465, updated on 2-May-2024

Summary

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Official Symbol
Hrh1provided by MGI
Official Full Name
histamine receptor H1provided by MGI
Primary source
MGI:MGI:107619
See related
Ensembl:ENSMUSG00000053004 AllianceGenome:MGI:107619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H1R; Hir; Bphs; HH1R
Summary
Predicted to enable several functions, including G protein-coupled serotonin receptor activity; calcium ion transmembrane transporter activity; and histamine binding activity. Acts upstream of or within memory; regulation of synaptic plasticity; and visual learning. Predicted to be located in cytosol and plasma membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in brain; stomach; and uterus. Orthologous to human HRH1 (histamine receptor H1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 2.2), colon adult (RPKM 1.7) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 E3; 6 53.05 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (114374897..114459432)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (114397936..114483298)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter, GABA), member 1 Neighboring gene predicted gene, 38875 Neighboring gene STARR-positive B cell enhancer ABC_E9098 Neighboring gene autophagy related 7 Neighboring gene STARR-seq mESC enhancer starr_17063 Neighboring gene predicted gene, 52917 Neighboring gene calmodulin regulated spectrin-associated protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Histamine H(1) receptor on astrocytes and neurons controls distinct aspects of mouse behaviour. Kárpáti A, et al. Sci Rep, 2019 Nov 11. PMID 31712580, Free PMC Article
  2. The effects of histamine H1 type receptor (H1R) in regulating osteoblastic cell differentiation and mineralization. Sun Y, et al. Artif Cells Nanomed Biotechnol, 2019 Dec. PMID 30942635
  3. The antihistamine olopatadine regulates T cell activation in palladium allergy. Iguchi N, et al. Int Immunopharmacol, 2016 Jun. PMID 27035718
  4. Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model. Parmentier R, et al. Neuropharmacology, 2016 Jul. PMID 26723880
  5. Impaired spatial learning and reduced adult hippocampal neurogenesis in histamine H1-receptor knockout mice. Ambrée O, et al. Eur Neuropsychopharmacol, 2014 Aug. PMID 24862254

See all (119) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disruption of Histamine-H1R signaling exacerbates cardiac microthrombosis after periodontal disease via TLR4/NFkappaB-p65 pathway.
    Title: Disruption of Histamine-H(1)R signaling exacerbates cardiac microthrombosis after periodontal disease via TLR4/NFκB-p65 pathway.
  2. TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors.
    Title: TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors.
  3. The role of pruriceptors in enhancing sensitivity to pruritogens in a murine chronic compression model of dorsal root ganglion.
    Title: The role of pruriceptors in enhancing sensitivity to pruritogens in a murine chronic compression model of dorsal root ganglion.
  4. effects of histamine H1 type receptor (H1R) in regulating osteoblastic cell differentiation and mineralization
    Title: The effects of histamine H1 type receptor (H1R) in regulating osteoblastic cell differentiation and mineralization.
  5. Data (including data from studies in knockout mice) suggest that sleep-promoting effect of dietary supplement rice bran is dependent on Hrh1 antagonism; rice bran fully inhibits Hrh1 agonist-induced increase in action potential frequency in tuberomammillary nucleus neurons.
    Title: A novel neurological function of rice bran: a standardized rice bran supplement promotes non-rapid eye movement sleep in mice through histamine H(1) receptors.
  6. Study showed that the sleep-wake cycle in H1-/- mice was affected both quantitatively and qualitatively: long-term abolition of histamine impairs cortical EEG, affects sleep-wake qualities and causes sleepiness facing behavioral challenges
    Title: Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model.
  7. this study shows that the histamine 1 receptor might be useful therapeutic target for treatment of metal allergy
    Title: The antihistamine olopatadine regulates T cell activation in palladium allergy.
  8. Sympathetic tone changed in H1R-, but not H2R- or H3R-null mice.
    Title: Involvement of the histamine H1 receptor in the regulation of sympathetic nerve activity.
  9. The results of this study suggest that H1R deficiency in mice is associated with pronounced deficits in hippocampus-dependent spatial learning and memory.
    Title: Impaired spatial learning and reduced adult hippocampal neurogenesis in histamine H1-receptor knockout mice.
  10. These results reveal a crucial role for H1- and H4-receptors for Th2 migration and cytokine secretion in a Th2-driven model of skin inflammation.
    Title: Delineating the role of histamine-1- and -4-receptors in a mouse model of Th2-dependent antigen-specific skin inflammation.
Submit: New GeneRIF Correction See all GeneRIFs (51)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables histamine binding ISO
Inferred from Sequence Orthology
more info
  
enables histamine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion import ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within cellular response to histamine ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within manganese ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
histamine H1 receptor
Names
Bordetella pertussis induced histamine sensitization

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252642.3 → NP_001239571.1  histamine H1 receptor

    See identical proteins and their annotated locations for NP_001239571.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 6. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AC159381
    Consensus CDS
    CCDS20435.1
    UniProtKB/Swiss-Prot
    P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3
    UniProtKB/TrEMBL
    B3Y5T0
    Related
    ENSMUSP00000124460.2, ENSMUST00000161650.3
    Conserved Domains (1) summary
    cd15050
    Location:29 → 480
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001252643.3 → NP_001239572.1  histamine H1 receptor

    See identical proteins and their annotated locations for NP_001239572.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 6. Variants 1 thorugh 6 encode the same protein.
    Source sequence(s)
    AC159381
    Consensus CDS
    CCDS20435.1
    UniProtKB/Swiss-Prot
    P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3
    UniProtKB/TrEMBL
    B3Y5T0
    Related
    ENSMUSP00000124037.2, ENSMUST00000161220.2
    Conserved Domains (1) summary
    cd15050
    Location:29 → 480
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001317124.2 → NP_001304053.1  histamine H1 receptor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 6. Variants 1 thorugh 6 encode the same protein.
    Source sequence(s)
    AC159381
    Consensus CDS
    CCDS20435.1
    UniProtKB/Swiss-Prot
    P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3
    UniProtKB/TrEMBL
    B3Y5T0
    Related
    ENSMUSP00000124320.2, ENSMUST00000160780.2
    Conserved Domains (1) summary
    cd15050
    Location:29 → 480
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_001317125.2 → NP_001304054.1  histamine H1 receptor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 6. Variants 1 thorugh 6 encode the same protein.
    Source sequence(s)
    AC159381
    Consensus CDS
    CCDS20435.1
    UniProtKB/Swiss-Prot
    P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3
    UniProtKB/TrEMBL
    B3Y5T0
    Conserved Domains (1) summary
    cd15050
    Location:29 → 480
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. NM_001317126.2 → NP_001304055.1  histamine H1 receptor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) represents the longest transcript. Variants 1 thorugh 6 encode the same protein.
    Source sequence(s)
    AC159381
    Consensus CDS
    CCDS20435.1
    UniProtKB/Swiss-Prot
    P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3
    UniProtKB/TrEMBL
    B3Y5T0
    Conserved Domains (1) summary
    cd15050
    Location:29 → 480
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  6. NM_001410031.1 → NP_001396960.1  histamine H1 receptor

    Status: VALIDATED

    Source sequence(s)
    AC159381
    UniProtKB/Swiss-Prot
    P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3
    UniProtKB/TrEMBL
    B3Y5T0

  7. NM_008285.5 → NP_032311.2  histamine H1 receptor

    See identical proteins and their annotated locations for NP_032311.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 6. Variants 1 through 6 encode the same protein.
    Source sequence(s)
    AC159381
    Consensus CDS
    CCDS20435.1
    UniProtKB/Swiss-Prot
    P70174, Q91V75, Q91XN0, Q91XN1, Q91XN2, Q91XN3
    UniProtKB/TrEMBL
    B3Y5T0
    Related
    ENSMUSP00000086383.3, ENSMUST00000088987.3
    Conserved Domains (1) summary
    cd15050
    Location:29 → 480
    7tmA_Histamine_H1R; histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    114374897..114459432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70174.2 GenPept UniProtKB/Swiss-Prot:P70174

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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