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Hmga1 high mobility group AT-hook 1 [ Mus musculus (house mouse) ]

Gene ID: 15361, updated on 18-Apr-2024

Summary

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Official Symbol
Hmga1provided by MGI
Official Full Name
high mobility group AT-hook 1provided by MGI
Primary source
MGI:MGI:96160
See related
Ensembl:ENSMUSG00000046711 AllianceGenome:MGI:96160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hmgi; Hmgy; Hmgiy; Hmga1a; Hmga1b
Summary
This locus encodes a member of the nuclear, non-histone high mobility group protein family. This architectural transcription factor binds to A-T rich DNA sequences and participates in enhanceosome formation, chromatin remodeling and regulation of transcription. This protein functions in many cellular processes, including cell growth and differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in thymus adult (RPKM 119.5), liver E14.5 (RPKM 82.7) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 14.5 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27774798..27782649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27556574..27563672)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16005 Neighboring gene STARR-seq mESC enhancer starr_42159 Neighboring gene STARR-seq mESC enhancer starr_42160 Neighboring gene predicted gene 9703 Neighboring gene STARR-seq mESC enhancer starr_42162 Neighboring gene small integral membrane protein 29 Neighboring gene nudix hydrolase 3 Neighboring gene STARR-positive B cell enhancer ABC_E8662 Neighboring gene STARR-seq mESC enhancer starr_42166

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression. Li L, et al. Blood, 2022 May 5. PMID 35286385, Free PMC Article
  2. Asymmetric expression of maternal mRNA governs first cell-fate decision. Wang Y, et al. FASEB J, 2021 Nov. PMID 34694646
  3. HMGA1-pseudogene7 transgenic mice develop B cell lymphomas. De Martino M, et al. Sci Rep, 2020 Apr 27. PMID 32341372, Free PMC Article
  4. High-mobility group AT-hook 1 promotes cardiac dysfunction in diabetic cardiomyopathy via autophagy inhibition. Wu QQ, et al. Cell Death Dis, 2020 Mar 2. PMID 32123163, Free PMC Article
  5. Hmga1 null mouse embryonic fibroblasts display downregulation of spindle assembly checkpoint gene expression associated to nuclear and karyotypic abnormalities. Pierantoni GM, et al. Cell Cycle, 2016. PMID 26889953, Free PMC Article

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression.
    Title: HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression.
  2. High-mobility group AT-Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling.
    Title: High-mobility group AT-Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling.
  3. Asymmetric expression of maternal mRNA governs first cell-fate decision.
    Title: Asymmetric expression of maternal mRNA governs first cell-fate decision.
  4. High-mobility group AT-hook 1 promotes cardiac dysfunction in diabetic cardiomyopathy via autophagy inhibition.
    Title: High-mobility group AT-hook 1 promotes cardiac dysfunction in diabetic cardiomyopathy via autophagy inhibition.
  5. HMGA1-pseudogene7 transgenic mice develop B cell lymphomas.
    Title: HMGA1-pseudogene7 transgenic mice develop B cell lymphomas.
  6. Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice.
    Title: Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice.
  7. findings highlight a novel FoxO1/HMGA1-mediated mechanism by which insulin may regulate gene expression and metabolism.
    Title: Cross-talk among HMGA1 and FoxO1 in control of nuclear insulin signaling.
  8. HMGA1 expression was closely correlated with the clinical stage, histological grade, and tumor size in breast cancer patients and breast cancer progression in transgenic MMTV-PyMT mice
    Title: HMGA1 Overexpression is Associated With the Malignant Status and Progression of Breast Cancer.
  9. Results define a unique role for Hmga1 in intestinal homeostasis by maintaining the stem cell pool and fostering terminal differentiation to establish an epithelial stem cell niche.
    Title: HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche.
  10. Forced expression of HMGA1 in primary cultured hepatocytes from Hmga1 (-/-) mice increased FoxO1 mRNA and protein levels.
    Title: HMGA1 is a novel transcriptional regulator of the FoxO1 gene.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102580

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-deoxyribose-5-phosphate lyase activity ISO
Inferred from Sequence Orthology
more info
  
enables D-loop DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding, bending ISO
Inferred from Sequence Orthology
more info
  
enables DNA-(apurinic or apyrimidinic site) endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables minor groove of adenine-thymine-rich DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables minor groove of adenine-thymine-rich DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear retinoic acid receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear retinoid X receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of chromatin TAS
Traceable Author Statement
more info
 PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within autophagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inflammatory cell apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lung morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within lymphoid progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oncogene-induced cell senescence ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peroxisome proliferator activated receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within respiratory system process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to cAMP IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to glucagon IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to glucose IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to insulin IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to insulin IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to insulin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thyroid gland development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SUMO ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of senescence-associated heterochromatin focus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
high mobility group protein HMG-I/HMG-Y
Names
high mobility group AT-hook protein 1
high mobility group protein A1
high mobility group protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025427.3 → NP_001020598.1  high mobility group protein HMG-I/HMG-Y isoform a

    See identical proteins and their annotated locations for NP_001020598.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same isoform (a), also known as isoform I.
    Source sequence(s)
    AK171334, AV018894, BY270784
    Consensus CDS
    CCDS28564.1
    UniProtKB/Swiss-Prot
    P17095, Q91WV2, Q924L7, Q924L8
    UniProtKB/TrEMBL
    Q566K0
    Related
    ENSMUSP00000156173.2, ENSMUST00000232265.2

  2. NM_001039356.2 → NP_001034445.1  high mobility group protein HMG-I/HMG-Y isoform a

    See identical proteins and their annotated locations for NP_001034445.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same isoform (a), also known as isoform I.
    Source sequence(s)
    AK171334, AV018894, BY270784, GH454882
    Consensus CDS
    CCDS28564.1
    UniProtKB/Swiss-Prot
    P17095, Q91WV2, Q924L7, Q924L8
    UniProtKB/TrEMBL
    Q566K0
    Related
    ENSMUSP00000113015.2, ENSMUST00000118599.9
    Conserved Domains (1) summary
    pfam06217
    Location:4 → 87
    GAGA_bind; GAGA binding protein-like family

  3. NM_001166535.1 → NP_001160007.1  high mobility group protein HMG-I/HMG-Y isoform a

    See identical proteins and their annotated locations for NP_001160007.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same isoform (a), also known as isoform I.
    Source sequence(s)
    AK171334, AV018894, BY165675, BY270784
    Consensus CDS
    CCDS28564.1
    UniProtKB/Swiss-Prot
    P17095, Q91WV2, Q924L7, Q924L8
    UniProtKB/TrEMBL
    Q566K0
    Related
    ENSMUSP00000113916.2, ENSMUST00000119486.9
    Conserved Domains (1) summary
    pfam06217
    Location:4 → 87
    GAGA_bind; GAGA binding protein-like family

  4. NM_001166536.1 → NP_001160008.1  high mobility group protein HMG-I/HMG-Y isoform a

    See identical proteins and their annotated locations for NP_001160008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same isoform (a), also known as isoform I.
    Source sequence(s)
    AK171334, AV018894, BY270784
    Consensus CDS
    CCDS28564.1
    UniProtKB/Swiss-Prot
    P17095, Q91WV2, Q924L7, Q924L8
    UniProtKB/TrEMBL
    Q566K0
    Related
    ENSMUSP00000155886.2, ENSMUST00000232013.2
    Conserved Domains (1) summary
    pfam06217
    Location:4 → 87
    GAGA_bind; GAGA binding protein-like family

  5. NM_001166537.1 → NP_001160009.1  high mobility group protein HMG-I/HMG-Y isoform b

    See identical proteins and their annotated locations for NP_001160009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 6 through 10 encode the same isoform (b), also known as isoform Y.
    Source sequence(s)
    AK155661, AK171334, AV018894, BM937661, CF730372
    Consensus CDS
    CCDS50044.1
    UniProtKB/TrEMBL
    A0A338P6G6, Q3TVP0
    Related
    ENSMUSP00000114101.2, ENSMUST00000118570.2
    Conserved Domains (1) summary
    PRK10475
    Location:31 → 75
    PRK10475; 23S rRNA pseudouridine synthase F; Provisional

  6. NM_001166539.1 → NP_001160011.1  high mobility group protein HMG-I/HMG-Y isoform b

    See identical proteins and their annotated locations for NP_001160011.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 6 through 10 encode the same isoform (b), also known as isoform Y.
    Source sequence(s)
    AK171334, AV018894, BY270784, GH454882
    Consensus CDS
    CCDS50044.1
    UniProtKB/TrEMBL
    A0A338P6G6, Q3TVP0
    Related
    ENSMUSP00000156327.2, ENSMUST00000231825.2
    Conserved Domains (1) summary
    PRK10475
    Location:31 → 75
    PRK10475; 23S rRNA pseudouridine synthase F; Provisional

  7. NM_001166540.1 → NP_001160012.1  high mobility group protein HMG-I/HMG-Y isoform b

    See identical proteins and their annotated locations for NP_001160012.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 6 through 10 encode the same isoform (b), also known as isoform Y.
    Source sequence(s)
    AK155661, AK171334, AV018894, BY165675, BY270784
    Consensus CDS
    CCDS50044.1
    UniProtKB/TrEMBL
    A0A338P6G6, Q3TVP0
    Related
    ENSMUSP00000156044.2, ENSMUST00000232552.2
    Conserved Domains (1) summary
    PRK10475
    Location:31 → 75
    PRK10475; 23S rRNA pseudouridine synthase F; Provisional

  8. NM_001166541.1 → NP_001160013.1  high mobility group protein HMG-I/HMG-Y isoform b

    See identical proteins and their annotated locations for NP_001160013.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 6 through 10 encode the same isoform (b), also known as isoform Y.
    Source sequence(s)
    AK155661, AK171334, AV018894, BY270784
    Consensus CDS
    CCDS50044.1
    UniProtKB/TrEMBL
    A0A338P6G6, Q3TVP0
    Related
    ENSMUSP00000110538.4, ENSMUST00000114888.11
    Conserved Domains (1) summary
    PRK10475
    Location:31 → 75
    PRK10475; 23S rRNA pseudouridine synthase F; Provisional

  9. NM_001166542.1 → NP_001160014.1  high mobility group protein HMG-I/HMG-Y isoform b

    See identical proteins and their annotated locations for NP_001160014.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 6 through 10 encode the same isoform (b), also known as isoform Y.
    Source sequence(s)
    AK155661, AK171334, AV018894, BY270784
    Consensus CDS
    CCDS50044.1
    UniProtKB/TrEMBL
    A0A338P6G6, Q3TVP0
    Related
    ENSMUSP00000155876.2, ENSMUST00000231358.2
    Conserved Domains (1) summary
    PRK10475
    Location:31 → 75
    PRK10475; 23S rRNA pseudouridine synthase F; Provisional

  10. NM_001166543.1 → NP_001160015.1  high mobility group protein HMG-I/HMG-Y isoform c

    See identical proteins and their annotated locations for NP_001160015.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and uses an alternate, in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a. Variants 11 and 12 encode the same isoform (c).
    Source sequence(s)
    AK171334, AV018894, BY165675, BY270784
    Consensus CDS
    CCDS89033.1
    UniProtKB/TrEMBL
    Q3TE85
    Related
    ENSMUSP00000155874.2, ENSMUST00000232253.2
    Conserved Domains (1) summary
    pfam06217
    Location:4 → 101
    GAGA_bind; GAGA binding protein-like family

  11. NM_001166544.1 → NP_001160016.1  high mobility group protein HMG-I/HMG-Y isoform c

    See identical proteins and their annotated locations for NP_001160016.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and uses an alternate, in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a. Variants 11 and 12 encode the same isoform (c).
    Source sequence(s)
    AK171334, AV018894, BY270784
    Consensus CDS
    CCDS89033.1
    UniProtKB/TrEMBL
    Q3TE85
    Related
    ENSMUSP00000113068.3, ENSMUST00000117600.9
    Conserved Domains (1) summary
    pfam06217
    Location:4 → 101
    GAGA_bind; GAGA binding protein-like family

  12. NM_001166545.1 → NP_001160017.1  high mobility group protein HMG-I/HMG-Y isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (d) is longer than isoform a.
    Source sequence(s)
    AK171334, AV018894, BY270784, CF951929
    Consensus CDS
    CCDS89032.1
    UniProtKB/TrEMBL
    A0A338P6E8
    Related
    ENSMUSP00000155922.2, ENSMUST00000231796.2

  13. NM_001166546.1 → NP_001160018.1  high mobility group protein HMG-I/HMG-Y isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform e, which has a longer and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK171334, AV018894, BY270784
    Consensus CDS
    CCDS89034.1
    UniProtKB/TrEMBL
    A0A338P6F6
    Related
    ENSMUSP00000155966.2, ENSMUST00000231866.2

  14. NM_001412718.1 → NP_001399647.1  high mobility group protein HMG-I/HMG-Y isoform b

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    Q3TVP0

  15. NM_001412721.1 → NP_001399650.1  high mobility group protein HMG-I/HMG-Y isoform f

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    A0A338P6D0

  16. NM_001412722.1 → NP_001399651.1  high mobility group protein HMG-I/HMG-Y isoform f

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    A0A338P6D0

  17. NM_001412723.1 → NP_001399652.1  high mobility group protein HMG-I/HMG-Y isoform e

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    A0A338P6F6

  18. NM_001412724.1 → NP_001399653.1  high mobility group protein HMG-I/HMG-Y isoform e

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    A0A338P6F6

  19. NM_001412726.1 → NP_001399655.1  high mobility group protein HMG-I/HMG-Y isoform f

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    A0A338P6D0

  20. NM_001412727.1 → NP_001399656.1  high mobility group protein HMG-I/HMG-Y isoform e

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    A0A338P6F6

  21. NM_001412728.1 → NP_001399657.1  high mobility group protein HMG-I/HMG-Y isoform f

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    A0A338P6D0
    Related
    ENSMUSP00000155919.2, ENSMUST00000231243.2

  22. NM_001412729.1 → NP_001399658.1  high mobility group protein HMG-I/HMG-Y isoform d

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    A0A338P6E8

  23. NM_001412730.1 → NP_001399659.1  high mobility group protein HMG-I/HMG-Y isoform d

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    A0A338P6E8

  24. NM_001412731.1 → NP_001399660.1  high mobility group protein HMG-I/HMG-Y isoform a

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/Swiss-Prot
    P17095, Q91WV2, Q924L7, Q924L8
    UniProtKB/TrEMBL
    Q566K0

  25. NM_001412732.1 → NP_001399661.1  high mobility group protein HMG-I/HMG-Y isoform a

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/Swiss-Prot
    P17095, Q91WV2, Q924L7, Q924L8
    UniProtKB/TrEMBL
    Q566K0

  26. NM_001412733.1 → NP_001399662.1  high mobility group protein HMG-I/HMG-Y isoform a

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/Swiss-Prot
    P17095, Q91WV2, Q924L7, Q924L8
    UniProtKB/TrEMBL
    Q566K0

  27. NM_001412740.1 → NP_001399669.1  high mobility group protein HMG-I/HMG-Y isoform a

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/Swiss-Prot
    P17095, Q91WV2, Q924L7, Q924L8
    UniProtKB/TrEMBL
    Q566K0

  28. NM_001412748.1 → NP_001399677.1  high mobility group protein HMG-I/HMG-Y isoform g

    Status: REVIEWED

    Source sequence(s)
    AC127341

  29. NM_001412749.1 → NP_001399678.1  high mobility group protein HMG-I/HMG-Y isoform g

    Status: REVIEWED

    Source sequence(s)
    AC127341

  30. NM_001412750.1 → NP_001399679.1  high mobility group protein HMG-I/HMG-Y isoform h

    Status: REVIEWED

    Source sequence(s)
    AC127341

  31. NM_001412751.1 → NP_001399680.1  high mobility group protein HMG-I/HMG-Y isoform g

    Status: REVIEWED

    Source sequence(s)
    AC127341

  32. NM_001412752.1 → NP_001399681.1  high mobility group protein HMG-I/HMG-Y isoform g

    Status: REVIEWED

    Source sequence(s)
    AC127341

  33. NM_001412754.1 → NP_001399683.1  high mobility group protein HMG-I/HMG-Y isoform h

    Status: REVIEWED

    Source sequence(s)
    AC127341

  34. NM_001412755.1 → NP_001399684.1  high mobility group protein HMG-I/HMG-Y isoform h

    Status: REVIEWED

    Source sequence(s)
    AC127341

  35. NM_001412764.1 → NP_001399693.1  high mobility group protein HMG-I/HMG-Y isoform h

    Status: REVIEWED

    Source sequence(s)
    AC127341

  36. NM_001412765.1 → NP_001399694.1  high mobility group protein HMG-I/HMG-Y isoform g

    Status: REVIEWED

    Source sequence(s)
    AC127341

  37. NM_001412766.1 → NP_001399695.1  high mobility group protein HMG-I/HMG-Y isoform c

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    Q3TE85

  38. NM_001412767.1 → NP_001399696.1  high mobility group protein HMG-I/HMG-Y isoform c

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    Q3TE85

  39. NM_001412768.1 → NP_001399697.1  high mobility group protein HMG-I/HMG-Y isoform c

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    Q3TE85

  40. NM_001412769.1 → NP_001399698.1  high mobility group protein HMG-I/HMG-Y isoform c

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    Q3TE85

  41. NM_001412770.1 → NP_001399699.1  high mobility group protein HMG-I/HMG-Y isoform i

    Status: REVIEWED

    Source sequence(s)
    AC127341

  42. NM_001412771.1 → NP_001399700.1  high mobility group protein HMG-I/HMG-Y isoform i

    Status: REVIEWED

    Source sequence(s)
    AC127341

  43. NM_001412772.1 → NP_001399701.1  high mobility group protein HMG-I/HMG-Y isoform i

    Status: REVIEWED

    Source sequence(s)
    AC127341

  44. NM_001412773.1 → NP_001399702.1  high mobility group protein HMG-I/HMG-Y isoform i

    Status: REVIEWED

    Source sequence(s)
    AC127341

  45. NM_001412783.1 → NP_001399712.1  high mobility group protein HMG-I/HMG-Y isoform b

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    Q3TVP0

  46. NM_001412943.1 → NP_001399872.1  high mobility group protein HMG-I/HMG-Y isoform j

    Status: REVIEWED

    Source sequence(s)
    AC127341

  47. NM_001412944.1 → NP_001399873.1  high mobility group protein HMG-I/HMG-Y isoform j

    Status: REVIEWED

    Source sequence(s)
    AC127341

  48. NM_001412945.1 → NP_001399874.1  high mobility group protein HMG-I/HMG-Y isoform j

    Status: REVIEWED

    Source sequence(s)
    AC127341

  49. NM_001412949.1 → NP_001399878.1  high mobility group protein HMG-I/HMG-Y isoform b

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    Q3TVP0

  50. NM_001412950.1 → NP_001399879.1  high mobility group protein HMG-I/HMG-Y isoform b

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    Q3TVP0

  51. NM_001412951.1 → NP_001399880.1  high mobility group protein HMG-I/HMG-Y isoform k

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    A0A384DV79

  52. NM_001412952.1 → NP_001399881.1  high mobility group protein HMG-I/HMG-Y isoform k

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    A0A384DV79
    Related
    ENSMUSP00000113011.3, ENSMUST00000117254.9

  53. NM_001412953.1 → NP_001399882.1  high mobility group protein HMG-I/HMG-Y isoform k

    Status: REVIEWED

    Source sequence(s)
    AC127341
    UniProtKB/TrEMBL
    A0A384DV79

  54. NM_001412954.1 → NP_001399883.1  high mobility group protein HMG-I/HMG-Y isoform L

    Status: REVIEWED

    Source sequence(s)
    AC127341

  55. NM_001412955.1 → NP_001399884.1  high mobility group protein HMG-I/HMG-Y isoform m

    Status: REVIEWED

    Source sequence(s)
    AC127341

  56. NM_001412956.1 → NP_001399885.1  high mobility group protein HMG-I/HMG-Y isoform m

    Status: REVIEWED

    Source sequence(s)
    AC127341

  57. NM_001412957.1 → NP_001399886.1  high mobility group protein HMG-I/HMG-Y isoform m

    Status: REVIEWED

    Source sequence(s)
    AC127341

  58. NM_001412958.1 → NP_001399887.1  high mobility group protein HMG-I/HMG-Y isoform n

    Status: REVIEWED

    Source sequence(s)
    AC127341

  59. NM_001412959.1 → NP_001399888.1  high mobility group protein HMG-I/HMG-Y isoform n

    Status: REVIEWED

    Source sequence(s)
    AC127341

  60. NM_001413142.1 → NP_001400071.1  high mobility group protein HMG-I/HMG-Y isoform r

    Status: REVIEWED

    Source sequence(s)
    AC127341

  61. NM_001413143.1 → NP_001400072.1  high mobility group protein HMG-I/HMG-Y isoform q

    Status: REVIEWED

    Source sequence(s)
    AC127341

  62. NM_001413144.1 → NP_001400073.1  high mobility group protein HMG-I/HMG-Y isoform p

    Status: REVIEWED

    Source sequence(s)
    AC127341

  63. NM_016660.3 → NP_057869.2  high mobility group protein HMG-I/HMG-Y isoform a

    See identical proteins and their annotated locations for NP_057869.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1 through 5 encode the same isoform (a), also known as isoform I.
    Source sequence(s)
    AK171334, AV018894, BM937661, CF730372
    Consensus CDS
    CCDS28564.1
    UniProtKB/Swiss-Prot
    P17095, Q91WV2, Q924L7, Q924L8
    UniProtKB/TrEMBL
    Q566K0
    Related
    ENSMUSP00000156199.2, ENSMUST00000231874.2
    Conserved Domains (1) summary
    pfam06217
    Location:4 → 87
    GAGA_bind; GAGA binding protein-like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    27774798..27782649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17095.4 GenPept UniProtKB/Swiss-Prot:P17095

Gene LinkOut

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