Hells helicase, lymphoid specific [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hellsprovided by MGI
Official Full Name: helicase, lymphoid specificprovided by MGI
Primary source: MGI:MGI:106209
See related: Ensembl:ENSMUSG00000025001 AllianceGenome:MGI:106209
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LSH; Lysh; PASG; YFK8; E130115I21Rik
Summary: Enables chromatin binding activity. Involved in DNA methylation-dependent heterochromatin assembly; maintenance of DNA methylation; and pericentric heterochromatin assembly. Acts upstream of or within several processes, including DNA methylation; cellular response to leukemia inhibitory factor; and negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus and pericentric heterochromatin. Is expressed in several structures, including central nervous system; gut; neural retina; reproductive system; and thymus. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 12.2), liver E14 (RPKM 8.5) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 33.57 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (38913282..38958914)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (38930262..38970470)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells.
Title: Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells.
Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis.
Title: Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis.
PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment.
Title: PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment.
LSH mediates gene repression through macroH2A deposition.
Title: LSH mediates gene repression through macroH2A deposition.
The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation.
Title: The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation.
Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination.
Title: Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination.
Helicase LSH/Hells regulates kinetochore function, histone H3/Thr3 phosphorylation and centromere transcription during oocyte meiosis.
Title: Helicase LSH/Hells regulates kinetochore function, histone H3/Thr3 phosphorylation and centromere transcription during oocyte meiosis.
By altering the nucleosome occupancy at the nucleosome-free region and enhancer, HELLS epigenetically suppresses multiple tumor suppressor genes to promote hepatocellular carcinoma progression.
Title: HELLS Regulates Chromatin Remodeling and Epigenetic Silencing of Multiple Tumor Suppressor Genes in Human Hepatocellular Carcinoma.
hot spot activation in which HELLS and PRDM9 form a pioneer complex to create a unique epigenomic environment of open chromatin, permitting correct placement and repair of DSBs
Title: HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots.
Lsh assists epigenetic gene repression upon binding to the Oct4 promoter region.
Title: Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (6) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hells (e-PCR), detects polymorphism
- UniSTS:259329

AI323785 (e-PCR)
- UniSTS:160832

NoName (e-PCR)
- UniSTS:237938

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA methylation-dependent heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA methylation-dependent heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromosomal DNA methylation maintenance following DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphocyte differentiation	TAS Traceable Author Statement more info	PubMed
involved_in lymphocyte proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in lymphocyte proliferation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression via chromosomal CpG island methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression via chromosomal CpG island methylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericentric heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in pericentric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within urogenital system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of pericentric heterochromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of pericentric heterochromatin	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lymphocyte-specific helicase

Names: proliferation-associated SNF2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008234.3 → NP_032260.2 lymphocyte-specific helicase

See identical proteins and their annotated locations for NP_032260.2

Status: VALIDATED

Source sequence(s)

AF155210

Consensus CDS

CCDS29789.1

UniProtKB/Swiss-Prot

Q497T3, Q60848, Q8VDZ1, Q9CYV7

Related

ENSMUSP00000025965.6, ENSMUST00000025965.12

Conserved Domains (2) summary

PLN03142
Location:204 → 781

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

cd18009
Location:203 → 436

DEXHc_HELLS_SMARCA6; DEXH-box helicase domain of HELLS

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

38913282..38958914

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526699.5 → XP_006526762.1 lymphocyte-specific helicase isoform X1

See identical proteins and their annotated locations for XP_006526762.1

UniProtKB/Swiss-Prot

Q497T3, Q60848, Q8VDZ1, Q9CYV7

Conserved Domains (2) summary

PLN03142
Location:204 → 781

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

cd18009
Location:203 → 436

DEXHc_HELLS_SMARCA6; DEXH-box helicase domain of HELLS
XM_006526700.4 → XP_006526763.1 lymphocyte-specific helicase isoform X2

Conserved Domains (1) summary

PLN03142
Location:4 → 437

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional