Hcfc1 host cell factor C1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hcfc1provided by MGI
Official Full Name: host cell factor C1provided by MGI
Primary source: MGI:MGI:105942
See related: Ensembl:ENSMUSG00000031386 AllianceGenome:MGI:105942
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HCF; HCF1
Summary: This gene encodes a transcription cofactor that regulates the progression of cell cycle and maintain the ability of embryonic stem cells to self-renew. The encoded protein is a large precursor that undergoes site-specific proteolytic cleavage to yield N- and C-terminal chains that form a non-covalent heterodimer. The encoded protein has been implicated in the regulation of expression of immediate early genes after herpes simplex virus infection and glucose-stimulated secretion of insulin by pancreatic beta cells. [provided by RefSeq, Aug 2015]
Expression: Ubiquitous expression in thymus adult (RPKM 54.5), adrenal adult (RPKM 25.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.52 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (72986400..73011430, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (73942792..73966995, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of the Transcriptional Coactivator HCF-1 In Vivo Impairs the Removal of Repressive Heterochromatin from Latent HSV Genomes and Suppresses the Initiation of Viral Reactivation.
Title: Deletion of the Transcriptional Coactivator HCF-1 In Vivo Impairs the Removal of Repressive Heterochromatin from Latent HSV Genomes and Suppresses the Initiation of Viral Reactivation.
MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1.
Title: MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1.
Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy.
Title: Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy.
In the brain, HCF-1 is important for organ development and cell proliferation.
Title: Cortical and Commissural Defects Upon HCF-1 Loss in Nkx2.1-Derived Embryonic Neurons and Glia.
These studies indicate HCF-1 is critical for glucocorticoid receptor activation of the viral immediate early genes and suggests that glucocorticoid induction of viral reactivation proceeds via an HCF-1- glucocorticoid receptor mechanism in the absence of the viral immediate early activator VP16.
Title: The Cellular Coactivator HCF-1 Is Required for Glucocorticoid Receptor-Mediated Transcription of Bovine Herpesvirus 1 Immediate Early Genes.
male epiblast-specific loss of Hcfc1 leads to a developmental arrest at E6.5 with a rapid progressive cell-cycle exit and an associated failure of anterior visceral endoderm migration and primitive streak formation.
Title: Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification.
Beyond its well-known role in adding beta-O-GlcNAc to serine and threonine residues of nuclear and cytoplasmic proteins, OGT also acts as a protease in the maturation of the cell cycle regulator, HCF-1, and serves as an integral member of several protein complexes, many of them linked to gene expression. (Review)
Title: The Biochemistry of O-GlcNAc Transferase: Which Functions Make It Essential in Mammalian Cells?
survival of the heterozygous Hcfc1(epiKO/+) female embryos llustrates the developmental plasticity of the post-implantation mouse embryo - in this instance, permitting survival of females heterozygous for an X-linked embryonic lethal allele
Title: Compensatory embryonic response to allele-specific inactivation of the murine X-linked gene Hcfc1.
our work identifies plausible cellular consequences of missense HCFC1 variants and identifies likely and relevant disease mechanisms that converge on embryonic stages of brain development.
Title: HCFC1 loss-of-function mutations disrupt neuronal and neural progenitor cells of the developing brain.
These results indicate that HCF-1 represents a novel transcriptional regulator required for maintaining pancreatic b-cell function.
Title: The transcriptional co-regulator HCF-1 is required for INS-1 β-cell glucose-stimulated insulin secretion.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW060991 (e-PCR)
- UniSTS:164669

U53925 (e-PCR)
- UniSTS:125773

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within blastocyst hatching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in release from viral latency	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
part_of MLL1/2 complex	ISO Inferred from Sequence Orthology more info
part_of NSL complex	ISO Inferred from Sequence Orthology more info
part_of Set1C/COMPASS complex	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of histone methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: host cell factor 1

Names: VP16 accessory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411234.1 → NP_001398163.1 host cell factor 1 isoform 1

Status: REVIEWED

Source sequence(s)

AL672002
NM_008224.5 → NP_032250.2 host cell factor 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_032250.2

Status: REVIEWED

Source sequence(s)

AL672002

Consensus CDS

CCDS30218.1

UniProtKB/Swiss-Prot

B1AUX1, Q61191, Q684R1, Q7TSB0, Q8C2D0, Q9QWH2

Related

ENSMUSP00000033761.7, ENSMUST00000033761.13

Conserved Domains (6) summary

PLN02153
Location:12 → 330

PLN02153; epithiospecifier protein

cd00063
Location:1866 → 1895

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00038
Location:200 → 253

Kelch; KELCH repeat [structural motif]

pfam01344
Location:32 → 69

Kelch_1; Kelch motif

pfam13415
Location:215 → 263

Kelch_3; Galactose oxidase, central domain

pfam13854
Location:134 → 179

Kelch_5; Kelch motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

72986400..73011430 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318387.3 → XP_017173876.1 host cell factor 1 isoform X3

Conserved Domains (5) summary

PLN02193
Location:27 → 322

PLN02193; nitrile-specifier protein

cd00063
Location:1867 → 1896

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00038
Location:200 → 253

Kelch; KELCH repeat [structural motif]

pfam05109
Location:441 → 771

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam13854
Location:319 → 351

Kelch_5; Kelch motif
XM_006527835.3 → XP_006527898.1 host cell factor 1 isoform X1

UniProtKB/TrEMBL

B1AUX2

Related

ENSMUSP00000110012.3, ENSMUST00000114372.3

Conserved Domains (5) summary

PLN02193
Location:27 → 322

PLN02193; nitrile-specifier protein

cd00063
Location:1911 → 1940

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

sd00038
Location:200 → 253

Kelch; KELCH repeat [structural motif]

pfam05109
Location:441 → 771

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam13854
Location:319 → 351

Kelch_5; Kelch motif