P/V/C C protein;V protein;phosphoprotein [Measles morbillivirus] - Gene

Summary

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Gene symbol: P/V/C
Gene description: C protein;V protein;phosphoprotein
Locus tag: MeVgp2
Gene type: protein coding
RNA name: P/V/C
RefSeq status: PROVISIONAL
Organism: Measles morbillivirus (strain: Ichinose-B95a)
Lineage: Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Paramyxoviridae; Morbillivirus
Also known as: P
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Genomic context

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Sequence:: NC_001498.1 (1748..3402)

NC_001498.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001498.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The V proteins were more potent inhibitors of IFN-inducible reporter gene expression than the C proteins, and this effect was unrelated to whether the protein originated from an attenuated or wild-type strain.
Title: Regulation of interferon signaling by the C and V proteins from attenuated and wild-type strains of measles virus.
identified and characterized the structure of an intermediate of the X domain of phosphoprotein (P) of measles virus.
Title: Identification and Structural Characterization of an Intermediate in the Folding of the Measles Virus X Domain.
The structure reveals the molecular details of the conserved N(0)-P interface and explains how P chaperones N(0), preventing both self-assembly of N(0) and its binding to RNA.
Title: Crystal Structure of the Measles Virus Nucleoprotein Core in Complex with an N-Terminal Region of Phosphoprotein.
Measles virus defective interfering RNAs are generated in the absence of C protein and can be destabilized by host ADAR1.
Title: Measles Virus Defective Interfering RNAs Are Generated Frequently and Early in the Absence of C Protein and Can Be Destabilized by Adenosine Deaminase Acting on RNA-1-Like Hypermutations.
The human PP1 interaction with the measles V protein is mediated by a conserved PP1-binding motif in the C-terminal region of the V protein.
Title: Antagonism of the phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5.
Loss of the P-N interaction results in reduced transcription.
Title: Sequence of events in measles virus replication: role of phosphoprotein-nucleocapsid interactions.
Experiments with paramyxovirus V protein-insensitive proteins revealed that the primary outcome of LGP2 interference is suppression of its ability to synergize with MDA5.
Title: Paramyxovirus V protein interaction with the antiviral sensor LGP2 disrupts MDA5 signaling enhancement but is not relevant to LGP2-mediated RLR signaling inhibition.
Data indicate that the viral RdRp polymerase complex is capable of productively docking directly to the nucleocapsid core.
Title: The measles virus nucleocapsid protein tail domain is dispensable for viral polymerase recruitment and activity.
The measles virus phosphoprotein interacts with the linker domain of STAT1.
Title: The measles virus phosphoprotein interacts with the linker domain of STAT1.
The intrinsically disordered C-terminal domain (N(TAIL) )of measles virus (MeV) nucleoprotein undergoes alpha-helical folding upon binding to the C-terminal X domain (XD) of the phosphoprotein. This study re-evaluate the role of Box3 in N(TAIL)-XD binding.
Title: Interaction between the C-terminal domains of measles virus nucleoprotein and phosphoprotein: a tight complex implying one binding site.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

General protein information

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Preferred Names: C protein;V protein;phosphoprotein

NP_056920.1

translated from overlapping reading frame in P/V/C mRNA using alternative start site

YP_003873249.2

translated from P/V/C mRNA modified by co-transcriptional insertion of non-templated G at genome position 2499 nt

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001498.1 Reference assembly

Range

1748..3402

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_056919.1 phosphoprotein [Measles morbillivirus]

See identical proteins and their annotated locations for NP_056919.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q9WMB4

UniProtKB/TrEMBL

A0A2Z5VFT7, A0A348GSU1, Q9QMM5

Conserved Domains (2) summary

pfam03210
Location:324 → 502

Paramyx_P_V_C; Paramyxovirus P/V phosphoprotein C-terminal

pfam13825
Location:4 → 312

Paramyxo_PNT; Paramyxovirus structural protein V/P N-terminus
YP_003873249.2 V protein [Measles morbillivirus]

See identical proteins and their annotated locations for YP_003873249.2

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P0C774

UniProtKB/TrEMBL

A0A348GSU2, A9YTL5

Conserved Domains (2) summary

pfam13008
Location:238 → 281

zf-Paramyx-P; Zinc-binding domain of Paramyxoviridae V protein

pfam13825
Location:4 → 231

Paramyxo_PNT; Paramyxovirus structural protein V/P N-terminus
NP_056920.1 C protein [Measles morbillivirus]

See identical proteins and their annotated locations for NP_056920.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q9YZN9

UniProtKB/TrEMBL

A0A1Z1DYM8, A9YTL6, A9YTM4, G5DD35, G5DD43, G5DD91, Q0WXY2, Q9YZZ4

Conserved Domains (1) summary

pfam02725
Location:11 → 174

Paramyxo_NS_C; Non-structural protein C