Gstp1 glutathione S-transferase, pi 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gstp1provided by MGI
Official Full Name: glutathione S-transferase, pi 1provided by MGI
Primary source: MGI:MGI:95865
See related: Ensembl:ENSMUSG00000060803 AllianceGenome:MGI:95865
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GstpiB
Summary: Enables JUN kinase binding activity; glutathione transferase activity; and kinase regulator activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of intracellular signal transduction; and negative regulation of macromolecule metabolic process. Acts upstream of or within glutathione metabolic process. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum adult (RPKM 772.3), stomach adult (RPKM 565.6) and 27 other tissues See more
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Genomic context

Location:: 19 A; 19 3.75 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (4085411..4087912, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (4035411..4037912, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway.
Title: GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway.
SIRT5-related lysine demalonylation of GSTP1 contributes to cardiomyocyte pyroptosis suppression in diabetic cardiomyopathy.
Title: SIRT5-related lysine demalonylation of GSTP1 contributes to cardiomyocyte pyroptosis suppression in diabetic cardiomyopathy.
Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex.
Title: Glutathione S-transferase Pi (Gstp) proteins regulate neuritogenesis in the developing cerebral cortex.
Histone methyltransferase G9a protects against acute liver injury through GSTP1.
Title: Histone methyltransferase G9a protects against acute liver injury through GSTP1.
A CRAF/glutathione-S-transferase P1 complex sustains autocrine growth of cancers with KRAS and BRAF mutations.
Title: A CRAF/glutathione-S-transferase P1 complex sustains autocrine growth of cancers with KRAS and BRAF mutations.
these results indicate that GSTpi-mediated S-glutathionylation of mouse SELENOW at Cys33 is required for the protection of cells in conditions of oxidative stress, through inhibition of the formation of the second disulfide bond.
Title: S-Glutathionylation of mouse selenoprotein W prevents oxidative stress-induced cell death by blocking the formation of an intramolecular disulfide bond.
GSTP is a redox chaperonine responsible for selective glutathionylation of protein Cys residues in different subcellular compartments [review]
Title: Targeting glutathione S-transferase P and its interactome with selenium compounds in cancer therapy.
this study shows GSTP prevents sepsis-related HMGB1 Protein translocation and release
Title: Glutathione S-Transferase Pi Prevents Sepsis-Related High Mobility Group Box-1 Protein Translocation and Release.
High GSTP1 expression is associated with head and neck squamous cell carcinoma.
Title: Piperlongumine and p53-reactivator APR-246 selectively induce cell death in HNSCC by targeting GSTP1.
Expression of both wild-type and catalytically-inactive Y7F mutant GSTP significantly attenuated LPS- or IKKbeta-induced production of GM-CSF. These studies indicate a complex role for GSTP in modulating NF-kappaB, which may involve S-glutathionylation of IKK proteins, and interaction with NF-kappaB family members.
Title: Glutathione S-transferase pi modulates NF-κB activation and pro-inflammatory responses in lung epithelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Wox36 (e-PCR)
- UniSTS:118102

PMC31882P1 (e-PCR)
- UniSTS:273095

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables JUN kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables S-nitrosoglutathione binding	ISO Inferred from Sequence Orthology more info
enables dinitrosyl-iron complex binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables kinase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables organic cyclic compound binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables toxic substance binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in common myeloid progenitor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glutathione derivative biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutathione metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione metabolic process	ISO Inferred from Sequence Orthology more info
involved_in hepoxilin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in linoleic acid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JUN kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of acute inflammatory response	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-1 beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of leukocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of monocyte chemotactic protein-1 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of monocyte chemotactic protein-1 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neutrophil aggregation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of nitric-oxide synthase biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of nitric-oxide synthase biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smooth muscle cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress-activated MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of stress-activated MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in response to reactive oxygen species	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TRAF2-GSTP1 complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutathione S-transferase P 1

Names: GST YF-YF; GST class-pi; GST-piB; Gst p-1; gst P1; preadipocyte growth factor

NP_038569.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013541.1 → NP_038569.1 glutathione S-transferase P 1

See identical proteins and their annotated locations for NP_038569.1

Status: VALIDATED

Source sequence(s)

D30687

Consensus CDS

CCDS29411.1

UniProtKB/Swiss-Prot

P19157, Q8BNY4

UniProtKB/TrEMBL

A0A494BAW2

Related

ENSMUSP00000129565.2, ENSMUST00000169613.4

Conserved Domains (3) summary

PTZ00057
Location:6 → 196

PTZ00057; glutathione s-transferase; Provisional

cd03210
Location:84 → 210

GST_C_Pi; C-terminal, alpha helical domain of Class Pi Glutathione S-transferases

cd03076
Location:3 → 76

GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...