Gsta4 glutathione S-transferase, alpha 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gsta4provided by MGI
Official Full Name: glutathione S-transferase, alpha 4provided by MGI
Primary source: MGI:MGI:1309515
See related: Ensembl:ENSMUSG00000032348 AllianceGenome:MGI:1309515
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GST5.7; mGsta4
Summary: Predicted to enable several functions, including glutathione peroxidase activity; glutathione transferase activity; and steroid delta-isomerase activity. Predicted to be involved in glutathione metabolic process and xenobiotic metabolic process. Predicted to be located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to human GSTA1 (glutathione S-transferase alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 693.7), stomach adult (RPKM 118.2) and 1 other tissue See more
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Genomic context

Location:: 9 E1; 9 43.65 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (78099248..78116631)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (78191966..78209349)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice.
Title: Effects of Gsta4 deficiency on age-related cochlear pathology and hearing loss in mice.
GSTA4-dependent detoxification may play a role in estrogen-mediated neuroprotection.
Title: GSTA4 mediates reduction of cisplatin ototoxicity in female mice.
Long-term adaptation to ethanol consumption in wild-type mice does not occur in GSTA4(-/-) mice.
Title: Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet.
Together, these results demonstrate the critical role of GSTA4 in blocking CKD-induced neointima formation and AVF failure.
Title: Reduced Expression of Glutathione S-Transferase α 4 Promotes Vascular Neointimal Hyperplasia in CKD.
Data define a role for GSTA4-4 in buffering hepatic oxidative stress associated with chronic alcohol consumption and that this GST isoform plays an important role in protecting against carbonylation of mitochondrial proteins.
Title: Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice.
although loss of GSTA4-4 led to enhanced susceptibility of cardiac mitochondria to radiation-induced loss of morphology, cardiac function was preserved in Gsta4-null mice
Title: Effects of Local Heart Irradiation in a Glutathione S-Transferase Alpha 4-Null Mouse Model.
These results indicate that 4-HNE significantly contributes to the mechanisms of tubule injury and fibrosis and that these effects can be inhibited by the enhanced expression of GSTA4-4.
Title: Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis.
In the absence of GSTA4-4 to modulate both physiological and pathological 4-hydroxynonenal (HNE) levels, the adaptive NRF-E2-related (Nrf)2 factor pathway may be primed to contribute to a preconditioned cardiac phenotype in the Gsta4-null mouse.
Title: Protection from oxidative and electrophilic stress in the Gsta4-null mouse heart.
The naturally occurring variation in Gsta4 expression in rats affects neurodegeneration after TBI. Further studies are needed to explore if genetic variability in Gsta4 can be associated to outcome also in human TBI.
Title: Naturally occurring variation in the Glutathione-S-Transferase 4 gene determines neurodegeneration after traumatic brain injury.
2-APB treatment restrained nasal lavage fluid LTC4, ECP, ovalbumin-specific IgE, and IL-4 and their corresponding mRNAs in the previously mentioned tissues of treated mice in comparison with those of control ones.
Title: 2-Aminoethoxydiphenyl borate administration into the nostril alleviates murine allergic rhinitis.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gsta4 (e-PCR), detects polymorphism
- UniSTS:527375

UniSTS:236204 (e-PCR)
- UniSTS:236204

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables glutathione transferase activity	TAS Traceable Author Statement more info	PubMed
enables organic cyclic compound binding	ISO Inferred from Sequence Orthology more info
enables toxic substance binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutathione S-transferase A4

Names: GST A4-4; GST class-alpha member 4; GSTA4-4; glutathione S-transferase 5.7

NP_034487.2

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010357.3 → NP_034487.2 glutathione S-transferase A4

See identical proteins and their annotated locations for NP_034487.2

Status: VALIDATED

Source sequence(s)

AI043064, AK008400, AK010098, AK019271, BU953110

Consensus CDS

CCDS23357.1

UniProtKB/Swiss-Prot

P24472, Q9CQ81, Q9CTY7, Q9CY87, Q9D038

Related

ENSMUSP00000034903.6, ENSMUST00000034903.7

Conserved Domains (3) summary

PTZ00057
Location:1 → 198

PTZ00057; glutathione s-transferase; Provisional

cd03208
Location:86 → 220

GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases

cd03077
Location:4 → 82

GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...