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Gsta3 glutathione S-transferase, alpha 3 [ Mus musculus (house mouse) ]

Gene ID: 14859, updated on 21-Apr-2024

Summary

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Official Symbol
Gsta3provided by MGI
Official Full Name
glutathione S-transferase, alpha 3provided by MGI
Primary source
MGI:MGI:95856
See related
Ensembl:ENSMUSG00000025934 AllianceGenome:MGI:95856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gst2-3
Summary
Enables glutathione transferase activity. Acts upstream of or within aflatoxin catabolic process and ureteric bud development. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; liver; nervous system; nose; and urinary system. Orthologous to human GSTA3 (glutathione S-transferase alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 172.7), liver adult (RPKM 140.8) and 8 other tissues See more
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Genomic context

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Location:
1 A4; 1 6.5 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (21310837..21335885)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (21240565..21265575)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene translocating chain-associating membrane protein 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:21030259-21030560 Neighboring gene STARR-seq mESC enhancer starr_00399 Neighboring gene transmembrane protein 14A Neighboring gene STARR-seq mESC enhancer starr_00401 Neighboring gene STARR-seq mESC enhancer starr_00402 Neighboring gene predicted gene, 32947 Neighboring gene predicted gene 28836 Neighboring gene STARR-seq mESC enhancer starr_00405 Neighboring gene STARR-seq mESC enhancer starr_00406 Neighboring gene predicted pseudogene 7094 Neighboring gene predicted gene 4956

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Participation of liver stem cells in cholangiocarcinogenesis after aflatoxin B(1) exposure of glutathione S-transferase A3 knockout mice. Ilic Z, et al. Tumour Biol, 2018 May. PMID 29804515
  2. Characterization of liver injury, oval cell proliferation and cholangiocarcinogenesis in glutathione S-transferase A3 knockout mice. Crawford DR, et al. Carcinogenesis, 2017 Jul 1. PMID 28535182, Free PMC Article
  3. Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2. Jowsey IR, et al. Biochem Biophys Res Commun, 2003 Dec 26. PMID 14652005
  4. Molecular cloning and heterologous expression of a cDNA encoding a mouse glutathione S-transferase Yc subunit possessing high catalytic activity for aflatoxin B1-8,9-epoxide. Hayes JD, et al. Biochem J, 1992 Jul 1. PMID 1637297, Free PMC Article
  5. Regulation of mouse glutathione S-transferases by chemoprotectors. Molecular evidence for the existence of three distinct alpha-class glutathione S-transferase subunits, Ya1, Ya2, and Ya3, in mouse liver. McLellan LI, et al. Biochem J, 1991 Jun 1. PMID 2049074, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. aflatoxin B1 induces cholangiocarcinomas in GSTA3-/- mice
    Title: Participation of liver stem cells in cholangiocarcinogenesis after aflatoxin B(1) exposure of glutathione S-transferase A3 knockout mice.
  2. There were no significant compensatory changes in KO mice GST subunits, GST enzymatic activity, epoxide hydrolase, or CYP1A2 and CYP3A11 levels. Finally, there was a modest increase in F2-isoprostane and isofuran in KO mice that confirmed putative GSTA3 hydroperoxidase activity in vivo for the first time.
    Title: Characterization of liver injury, oval cell proliferation and cholangiocarcinogenesis in glutathione S-transferase A3 knockout mice.
  3. Reporter gene assays demonstrated that mouse GSTA3 5(')-upstream region is activated by 15-deoxy-Delta(12,14)-prostaglandin J2 through an antioxidant response element, and that this may be involved in regulating GSTA3 expression during adipogenesis.
    Title: Expression of the murine glutathione S-transferase alpha3 (GSTA3) subunit is markedly induced during adipocyte differentiation: activation of the GSTA3 gene promoter by the pro-adipogenic eicosanoid 15-deoxy-Delta12,14-prostaglandin J2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aflatoxin catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ureteric bud development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
glutathione S-transferase A3
Names
GST class-alpha member 3
glutathione S-transferase Ya3
glutathione S-transferase Yc
NP_001070821.1
NP_001275546.1
NP_001407119.1
NP_001407120.1
NP_001407121.1
NP_001407122.1
NP_001407123.1
NP_001407124.1
NP_034486.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077353.3 → NP_001070821.1  glutathione S-transferase A3 isoform a

    See identical proteins and their annotated locations for NP_001070821.1

    Status: VALIDATED

    Source sequence(s)
    AC163025
    Consensus CDS
    CCDS14847.1
    UniProtKB/Swiss-Prot
    P30115, Q544Y6
    UniProtKB/TrEMBL
    Q9DCU1
    Related
    ENSMUSP00000113262.2, ENSMUST00000121676.8
    Conserved Domains (3) summary
    PTZ00057
    Location:1 → 198
    PTZ00057; glutathione s-transferase; Provisional
    cd03208
    Location:86 → 220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:4 → 82
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

  2. NM_001288617.2 → NP_001275546.1  glutathione S-transferase A3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC163025
    Conserved Domains (2) summary
    cd03208
    Location:36 → 170
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cl00388
    Location:1 → 32
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

  3. NM_001420190.1 → NP_001407119.1  glutathione S-transferase A3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC163025

  4. NM_001420191.1 → NP_001407120.1  glutathione S-transferase A3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC163025

  5. NM_001420192.1 → NP_001407121.1  glutathione S-transferase A3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC163025

  6. NM_001420193.1 → NP_001407122.1  glutathione S-transferase A3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC163025

  7. NM_001420194.1 → NP_001407123.1  glutathione S-transferase A3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC163025

  8. NM_001420195.1 → NP_001407124.1  glutathione S-transferase A3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC163025

  9. NM_010356.5 → NP_034486.2  glutathione S-transferase A3 isoform a

    See identical proteins and their annotated locations for NP_034486.2

    Status: VALIDATED

    Source sequence(s)
    AC163025
    Consensus CDS
    CCDS14847.1
    UniProtKB/Swiss-Prot
    P30115, Q544Y6
    UniProtKB/TrEMBL
    Q9DCU1
    Related
    ENSMUSP00000027067.9, ENSMUST00000027067.15
    Conserved Domains (3) summary
    PTZ00057
    Location:1 → 198
    PTZ00057; glutathione s-transferase; Provisional
    cd03208
    Location:86 → 220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:4 → 82
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    21310837..21335885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30115.2 GenPept UniProtKB/Swiss-Prot:P30115

Gene LinkOut

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