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Gsta1 glutathione S-transferase, alpha 1 (Ya) [ Mus musculus (house mouse) ]

Gene ID: 14857, updated on 4-Jan-2025

Summary

Official Symbol
Gsta1provided by MGI
Official Full Name
glutathione S-transferase, alpha 1 (Ya)provided by MGI
Primary source
MGI:MGI:1095417
See related
Ensembl:ENSMUSG00000074183 AllianceGenome:MGI:1095417
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gst2-1
Summary
Enables glutathione transferase activity. Involved in response to stilbenoid. Acts upstream of or within response to bacterium. Located in cytosol and mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; heart; skeleton; and urinary system. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in stomach adult (RPKM 111.8), duodenum adult (RPKM 95.5) and 3 other tissues See more
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Genomic context

See Gsta1 in Genome Data Viewer
Location:
9 E1; 9 43.65 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (78137951..78149965)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (78230669..78242683)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24720 Neighboring gene glutathione S-transferase, alpha 4 Neighboring gene preferentially expressed antigen in melanoma like 6 pseudogene Neighboring gene developmental pluripotency associated 5B Neighboring gene glutathione S-transferase alpha 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dinitrosyl-iron complex binding  
enables fatty acid binding  
enables glutathione binding  
enables glutathione peroxidase activity  
enables glutathione transferase activity  
enables glutathione transferase activity PubMed 
enables glutathione transferase activity PubMed 
enables glutathione transferase activity  
enables glutathione transferase activity  
enables peroxidase activity  
enables protein homodimerization activity  
enables steroid delta-isomerase activity  
enables steroid delta-isomerase activity  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification  
involved_in glutathione derivative biosynthetic process  
involved_in glutathione metabolic process  
acts_upstream_of_or_within glutathione metabolic process PubMed 
involved_in glutathione metabolic process  
involved_in prostaglandin metabolic process  
acts_upstream_of_or_within response to bacterium PubMed 
involved_in response to stilbenoid PubMed 
involved_in xenobiotic metabolic process  
Component Evidence Code Pubs
is_active_in cytosol  
located_in cytosol PubMed 
located_in cytosol  
located_in mitochondrion PubMed 

General protein information

Preferred Names
glutathione S-transferase A1
Names
13-hydroperoxyoctadecadienoate peroxidase
GST class-alpha member 1
androst-5-ene-3,17-dione isomerase
glutathione S-transferase Ya
glutathione S-transferase Ya1
NP_032207.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008181.3NP_032207.3  glutathione S-transferase A1

    See identical proteins and their annotated locations for NP_032207.3

    Status: VALIDATED

    Source sequence(s)
    BC132572, BY080629, CJ228212
    Consensus CDS
    CCDS23358.1
    UniProtKB/Swiss-Prot
    A2RTN4, P13745
    UniProtKB/TrEMBL
    Q8K0V9
    Related
    ENSMUSP00000096139.4, ENSMUST00000098537.4
    Conserved Domains (2) summary
    cd03208
    Location:86220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:482
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    78137951..78149965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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