Gsta1 glutathione S-transferase, alpha 1 (Ya) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gsta1provided by MGI
Official Full Name: glutathione S-transferase, alpha 1 (Ya)provided by MGI
Primary source: MGI:MGI:1095417
See related: Ensembl:ENSMUSG00000074183 AllianceGenome:MGI:1095417
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gst2-1
Summary: Predicted to enable several functions, including anion binding activity; dinitrosyl-iron complex binding activity; and glutathione peroxidase activity. Acts upstream of or within response to bacterium and response to stilbenoid. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; central nervous system; heart; skeleton; and urinary system. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 111.8), duodenum adult (RPKM 95.5) and 3 other tissues See more
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Genomic context

Location:: 9 E1; 9 43.65 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (78137951..78149965)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (78230669..78242683)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GSTA1 can be detected at the early stage of low concentration ethanol exposure and that GSTA1 is more sensitive and reliable marker in ethanol-induced hepatic injury.
Title: Glutathione S-transferase A1 - a sensitive marker of alcoholic injury on primary hepatocytes.
results suggest that GSTA1 can be detected at low concentrations during the early stages of acute hepatic injury and that GSTA1 is a more sensitive and more accurate indicator than ALT
Title: Glutathione S-transferase A1 (GSTA1) release, an early indicator of acute hepatic injury in mice.
Report increased GSTA1 in airways of asthmatic mice.
Title: Expression pattern of GSTP1 and GSTA1 in the pathogenesis of asthma.
Analysis of the expressed luciferase activity indicated that MMA activated the promoter 2.6-fold. MMA (from 1 to 30 mM) dose-dependently increased the promoter activity, which reached a plateau between 6 and 12 hrs.
Title: Methyl methacrylate activates the Gsta1 promoter.
This is the first demonstration that heavy metals (mercury, lead and copper) regulate the expression of Gst ya gene through a transcriptional mechanism.
Title: Transcriptional regulation of the NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase ya genes by mercury, lead, and copper.
Exceptional activity of murine glutathione transferase A1-1 against (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-induced DNA damage in stably transfected cells
Title: Exceptional activity of murine glutathione transferase A1-1 against (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-induced DNA damage in stably transfected cells.
mitochondrial Gsta1 is induced under oxidative stress
Title: Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress.
Essential roles of ERKs and p38K in up-regulation of GST A1 expression by Maotai content in human hepatoma cell line Hep3B.It is widely accepted that the consumption of alcohol may lead to hepatic injuries such as hepatic fibrosis and cirrhosis.
Title: Essential roles of ERKs and p38K in up-regulation of GST A1 expression by Maotai content in human hepatoma cell line Hep3B.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dinitrosyl-iron complex binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables glutathione binding	ISO Inferred from Sequence Orthology more info
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables steroid delta-isomerase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glutathione metabolic process	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione S-transferase A1

Names: 13-hydroperoxyoctadecadienoate peroxidase; GST class-alpha member 1; androst-5-ene-3,17-dione isomerase; glutathione S-transferase Ya; glutathione S-transferase Ya1

NP_032207.3

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008181.3 → NP_032207.3 glutathione S-transferase A1

See identical proteins and their annotated locations for NP_032207.3

Status: VALIDATED

Source sequence(s)

BC132572, BY080629, CJ228212

Consensus CDS

CCDS23358.1

UniProtKB/Swiss-Prot

A2RTN4, P13745

UniProtKB/TrEMBL

Q8K0V9

Related

ENSMUSP00000096139.4, ENSMUST00000098537.4

Conserved Domains (2) summary

cd03208
Location:86 → 220

GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases

cd03077
Location:4 → 82

GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...