U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Grk4 G protein-coupled receptor kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 14772, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Grk4provided by MGI
Official Full Name
G protein-coupled receptor kinase 4provided by MGI
Primary source
MGI:MGI:95801
See related
Ensembl:ENSMUSG00000052783 AllianceGenome:MGI:95801
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GRK; Gprk4; Gprk2l; A830025H08Rik
Summary
Predicted to enable rhodopsin kinase activity. Predicted to be involved in G protein-coupled receptor internalization and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol; dendrite; and neuronal cell body. Predicted to be active in cytoplasm. Is expressed in brain and testis. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human GRK4 (G protein-coupled receptor kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 7.6), bladder adult (RPKM 0.8) and 10 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Grk4 in Genome Data Viewer
Location:
5 B2; 5 17.91 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34817641..34912649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (34660250..34755305)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34979450-34979637 Neighboring gene major facilitator superfamily domain containing 10 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:35002815-35002998 Neighboring gene NOP14 nucleolar protein Neighboring gene predicted gene 15522 Neighboring gene microRNA 467g Neighboring gene STARR-positive B cell enhancer ABC_E1050 Neighboring gene huntingtin Neighboring gene Myb/SANT-like DNA-binding domain containing 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury. Yang D, et al. Kidney Int, 2023 Apr. PMID 36669643
  2. LncRNA 148400 Promotes the Apoptosis of Renal Tubular Epithelial Cells in Ischemic AKI by Targeting the miR-10b-3p/GRK4 Axis. Li X, et al. Cells, 2022 Dec 9. PMID 36552750, Free PMC Article
  3. G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes. Usui I, et al. Mol Endocrinol, 2005 Nov. PMID 15994203
  4. Back-translating GWAS findings to animal models reveals a role for Hgfac and Slc39a8 in alcohol and nicotine consumption. Banna FKE, et al. Sci Rep, 2022 Jun 4. PMID 35661789, Free PMC Article
  5. The FMRP/GRK4 mRNA interaction uncovers a new mode of binding of the Fragile X mental retardation protein in cerebellum. Maurin T, et al. Nucleic Acids Res, 2015 Sep 30. PMID 26250109, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D1R expression.
    Title: Exercise ameliorates skeletal muscle insulin resistance by modulating GRK4-mediated D1R expression.
  2. Effect of GRK4 on renal gastrin receptor regulation in hypertension.
    Title: Effect of GRK4 on renal gastrin receptor regulation in hypertension.
  3. Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury.
    Title: Downregulation of G protein-coupled receptor kinase 4 protects against kidney ischemia-reperfusion injury.
  4. LncRNA 148400 Promotes the Apoptosis of Renal Tubular Epithelial Cells in Ischemic AKI by Targeting the miR-10b-3p/GRK4 Axis.
    Title: LncRNA 148400 Promotes the Apoptosis of Renal Tubular Epithelial Cells in Ischemic AKI by Targeting the miR-10b-3p/GRK4 Axis.
  5. GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension.
    Title: GRK4-mediated adiponectin receptor-1 phosphorylative desensitization as a novel mechanism of reduced renal sodium excretion in hypertension.
  6. GRK4gamma gene variants (A>65L, A>142V, and A>486V) in mice causes Hypertension, although Salt Sensitivity depends on which is GRK4gamma variant is present.
    Title: Gastrorenal Axis.
  7. GRK2 inhibits WNT signaling in osteoblasts
    Title: Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2).
  8. The role of GRK2 in chronic ET-1-induced insulin resistance was investigated.
    Title: G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables rhodopsin kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in desensitization of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G protein-coupled receptor kinase 4
Names
G protein-coupled receptor kinase 2, groucho gene related
g protein-coupled receptor kinase GRK4
NP_001074212.1
NP_062370.2
XP_006503805.1
XP_017176159.1
XP_017176160.1
XP_030109995.1
XP_030109996.1
XP_030109997.1
XP_030109998.1
XP_036020689.1
XP_036020690.1
XP_036020691.1
XP_036020692.1
XP_036020693.1
XP_036020694.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080743.2 → NP_001074212.1  G protein-coupled receptor kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_001074212.1

    Status: VALIDATED

    Source sequence(s)
    AC151669
    Consensus CDS
    CCDS39070.1
    UniProtKB/TrEMBL
    Q8BP13
    Related
    ENSMUSP00000074223.5, ENSMUST00000074651.11
    Conserved Domains (1) summary
    cl02565
    Location:51 → 145
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  2. NM_019497.3 → NP_062370.2  G protein-coupled receptor kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_062370.2

    Status: VALIDATED

    Source sequence(s)
    AC151669
    Consensus CDS
    CCDS19219.1
    UniProtKB/Swiss-Prot
    O70291, Q3V151
    Related
    ENSMUSP00000001112.8, ENSMUST00000001112.14
    Conserved Domains (3) summary
    smart00220
    Location:186 → 448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05605
    Location:185 → 469
    STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
    cl02565
    Location:51 → 183
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    34817641..34912649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164798.1 → XP_036020691.1  G protein-coupled receptor kinase 4 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:1 → 259
    PKc_like; Protein Kinases, catalytic domain

  2. XM_036164800.1 → XP_036020693.1  G protein-coupled receptor kinase 4 isoform X7

    Conserved Domains (2) summary
    cl02565
    Location:51 → 183
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:185 → 352
    PKc_like; Protein Kinases, catalytic domain

  3. XM_006503742.5 → XP_006503805.1  G protein-coupled receptor kinase 4 isoform X8

    Conserved Domains (2) summary
    cl02565
    Location:51 → 183
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:185 → 352
    PKc_like; Protein Kinases, catalytic domain

  4. XM_017320670.3 → XP_017176159.1  G protein-coupled receptor kinase 4 isoform X4

    Conserved Domains (2) summary
    cd05605
    Location:185 → 468
    STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
    cl02565
    Location:51 → 183
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  5. XM_017320671.3 → XP_017176160.1  G protein-coupled receptor kinase 4 isoform X5

    Conserved Domains (3) summary
    cl02565
    Location:51 → 183
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl11395
    Location:373 → 438
    Pkinase_C; Protein kinase C terminal domain
    cl21453
    Location:185 → 393
    PKc_like; Protein Kinases, catalytic domain

  6. XM_036164796.1 → XP_036020689.1  G protein-coupled receptor kinase 4 isoform X1

    Conserved Domains (2) summary
    cd05605
    Location:185 → 469
    STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
    cl02565
    Location:51 → 183
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  7. XM_030254136.2 → XP_030109996.1  G protein-coupled receptor kinase 4 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:1 → 259
    PKc_like; Protein Kinases, catalytic domain

  8. XM_036164801.1 → XP_036020694.1  G protein-coupled receptor kinase 4 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:1 → 259
    PKc_like; Protein Kinases, catalytic domain

  9. XM_036164797.1 → XP_036020690.1  G protein-coupled receptor kinase 4 isoform X2

    Conserved Domains (2) summary
    cd05605
    Location:146 → 430
    STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
    cl02565
    Location:12 → 144
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  10. XM_030254135.2 → XP_030109995.1  G protein-coupled receptor kinase 4 isoform X3

    Conserved Domains (2) summary
    cd05605
    Location:145 → 429
    STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
    cl02565
    Location:11 → 143
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  11. XM_030254137.2 → XP_030109997.1  G protein-coupled receptor kinase 4 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:1 → 259
    PKc_like; Protein Kinases, catalytic domain

  12. XM_036164799.1 → XP_036020692.1  G protein-coupled receptor kinase 4 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:1 → 259
    PKc_like; Protein Kinases, catalytic domain

  13. XM_030254138.1 → XP_030109998.1  G protein-coupled receptor kinase 4 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:1 → 259
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_003955585.2 RNA Sequence

  2. XR_003955583.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70291.2 GenPept UniProtKB/Swiss-Prot:O70291

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous