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Ptgdr2 prostaglandin D2 receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 14764, updated on 2-May-2024

Summary

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Official Symbol
Ptgdr2provided by MGI
Official Full Name
prostaglandin D2 receptor 2provided by MGI
Primary source
MGI:MGI:1330275
See related
Ensembl:ENSMUSG00000034117 AllianceGenome:MGI:1330275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crth2; Gpr44; Grp45
Summary
Enables prostaglandin D receptor activity; prostaglandin F receptor activity; and prostaglandin J receptor activity. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of male germ cell proliferation; and positive regulation of G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR2 (prostaglandin D2 receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 2.6), subcutaneous fat pad adult (RPKM 1.9) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 7.4 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10901883..10919875)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10924519..10942511)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8738 Neighboring gene pre-mRNA processing factor 19 Neighboring gene zona pellucida glycoprotein 1 Neighboring gene STARR-positive B cell enhancer ABC_E5689 Neighboring gene coiled-coil domain containing 86 Neighboring gene membrane-spanning 4-domains, subfamily A, member 10 Neighboring gene STARR-seq mESC enhancer starr_45563 Neighboring gene STARR-positive B cell enhancer ABC_E11021 Neighboring gene STARR-positive B cell enhancer mm9_chr19:11054242-11054543 Neighboring gene membrane-spanning 4-domains, subfamily A, member 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. DP1 (Prostaglandin D(2) Receptor 1) Activation Protects Against Vascular Remodeling and Vascular Smooth Muscle Cell Transition to Myofibroblasts in Angiotensin II-Induced Hypertension in Mice. Zou F, et al. Hypertension, 2022 Jun. PMID 35354317
  2. Role of prostaglandin D2 receptors in the pathogenesis of abdominal aortic aneurysm formation. Weintraub NL, et al. Clin Sci (Lond), 2022 Mar 18. PMID 35132998, Free PMC Article
  3. PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection. Oyesola OO, et al. J Exp Med, 2021 Sep 6. PMID 34283207, Free PMC Article
  4. PGD(2) /CRTH2 signaling promotes acquired immunity against bee venom by enhancing IgE production. Kida M, et al. FASEB J, 2021 Jun. PMID 33978990
  5. Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium. Diwakar BT, et al. FASEB J, 2019 Nov. PMID 31518163, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DP1 (Prostaglandin D2 Receptor 1) Activation Protects Against Vascular Remodeling and Vascular Smooth Muscle Cell Transition to Myofibroblasts in Angiotensin II-Induced Hypertension in Mice.
    Title: DP1 (Prostaglandin D(2) Receptor 1) Activation Protects Against Vascular Remodeling and Vascular Smooth Muscle Cell Transition to Myofibroblasts in Angiotensin II-Induced Hypertension in Mice.
  2. Role of prostaglandin D2 receptors in the pathogenesis of abdominal aortic aneurysm formation.
    Title: Role of prostaglandin D2 receptors in the pathogenesis of abdominal aortic aneurysm formation.
  3. PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection.
    Title: PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection.
  4. ER-anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6.
    Title: ER-anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6.
  5. The Prostaglandin D2 Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung.
    Title: The Prostaglandin D(2) Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung.
  6. tudies present a novel regulatory role for Crth2 during inflammatory response in macrophages
    Title: Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium.
  7. Prostaglandin D2 (DP2) receptor expression is highest when the hair follicle begins regressing in hair growth cycles in mice strongly suggesting that the PGD2-DP2 receptor pathway plays a key role in the inhibition of hair growth.
    Title: Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression.
  8. The disease model is driven by gammadeltaT cells that express CRTH2.
    Title: Deficiency of CRTH2, a Prostaglandin D(2) Receptor, Aggravates Bleomycin-induced Pulmonary Inflammation and Fibrosis.
  9. Our study revealed that rising temperature of POA alters the activity of Ptgds-expressing neurons so as to increase PGD2 production.
    Title: Thermoregulation via Temperature-Dependent PGD(2) Production in Mouse Preoptic Area.
  10. the beneficial effects of DP2 blockade or DP1 agonism were associated with increased interferon-lambda (IFN-lambda) [interleukin-28A/B (IL-28A/B)] expression and were lost upon IL-28A neutralization.
    Title: PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC130436

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prostaglandin D receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prostaglandin D receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables prostaglandin D receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables prostaglandin F receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables prostaglandin J receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemotaxis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within negative regulation of male germ cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
prostaglandin D2 receptor 2
Names
G-protein coupled receptor 44
PGD2 receptor
chemoattractant receptor-homologous molecule expressed on TH2 cells
prostaglandin D2 receptor CRTH2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009962.3 → NP_034092.1  prostaglandin D2 receptor 2

    See identical proteins and their annotated locations for NP_034092.1

    Status: VALIDATED

    Source sequence(s)
    AC132402, AC148991, AK041947
    Consensus CDS
    CCDS29592.1
    UniProtKB/Swiss-Prot
    Q54A00, Q9Z2J6
    Related
    ENSMUSP00000036159.4, ENSMUST00000037261.4
    Conserved Domains (2) summary
    cd14964
    Location:34 → 58
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:32 → 314
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10901883..10919875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247148.4 → XP_011245450.1  prostaglandin D2 receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_011245450.1

    UniProtKB/Swiss-Prot
    Q54A00, Q9Z2J6
    Conserved Domains (2) summary
    cd14964
    Location:34 → 58
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:32 → 314
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_006526695.5 → XP_006526758.1  prostaglandin D2 receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_006526758.1

    UniProtKB/Swiss-Prot
    Q54A00, Q9Z2J6
    Conserved Domains (2) summary
    cd14964
    Location:34 → 58
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:32 → 314
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_006526696.5 → XP_006526759.1  prostaglandin D2 receptor 2 isoform X1

    See identical proteins and their annotated locations for XP_006526759.1

    UniProtKB/Swiss-Prot
    Q54A00, Q9Z2J6
    Conserved Domains (2) summary
    cd14964
    Location:34 → 58
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:32 → 314
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2J6.1 GenPept UniProtKB/Swiss-Prot:Q9Z2J6

Gene LinkOut

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