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Lpar1 lysophosphatidic acid receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 14745, updated on 18-Apr-2024

Summary

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Official Symbol
Lpar1provided by MGI
Official Full Name
lysophosphatidic acid receptor 1provided by MGI
Primary source
MGI:MGI:108429
See related
Ensembl:ENSMUSG00000038668 AllianceGenome:MGI:108429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Edg2; Kdt2; lpA1; vzg-1; Gpcr26
Summary
Enables PDZ domain binding activity and lysophosphatidic acid receptor activity. Involved in several processes, including activation of phospholipase C activity; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and positive regulation of stress fiber assembly. Acts upstream of or within bleb assembly; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 20.9), colon adult (RPKM 17.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B3; 4 32.2 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (58435252..58554601, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (58435252..58554027, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30907 Neighboring gene STARR-seq mESC enhancer starr_10356 Neighboring gene muscle, skeletal, receptor tyrosine kinase Neighboring gene STARR-seq mESC enhancer starr_10357 Neighboring gene STARR-seq mESC enhancer starr_10358 Neighboring gene microRNA 3095 Neighboring gene arginine/serine-rich coiled-coil 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_10361 Neighboring gene predicted gene, 54282 Neighboring gene predicted gene 12579 Neighboring gene STARR-seq mESC enhancer starr_10362 Neighboring gene STARR-seq mESC enhancer starr_10364 Neighboring gene STARR-seq mESC enhancer starr_10365 Neighboring gene olfactory receptor family 2 subfamily K member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibition of lysophosphatidic acid receptor 1 relieves PMN recruitment in CNS via LPA1/TSP1/CXCR2 pathway and alleviates disruption on blood-brain barrier following intracerebral haemorrhage in mice. Gao L, et al. Fluids Barriers CNS, 2023 May 10. PMID 37165450, Free PMC Article
  2. Lysophosphatidic acid receptor type-1 mediates brain activation in micro-positron emission tomography analysis in a fibromyalgia-like mouse model. Neyama H, et al. Eur J Neurosci, 2022 Aug. PMID 35666711
  3. Expression of lysophosphatidic acid receptor 1 in the adult female mouse pituitary gland. Moriyama R, et al. Neurosci Lett, 2021 Jan 10. PMID 33220367
  4. Conditional Lpar1 gene targeting identifies cell types mediating neuropathic pain. Rivera RR, et al. FASEB J, 2020 Jul. PMID 32929779, Free PMC Article
  5. Differential anatomical and cellular expression of lysophosphatidic acid receptor 1 in adult mouse brain. Kajitani N, et al. Biochem Biophys Res Commun, 2020 Oct 15. PMID 32718668

See all (165) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inhibition of lysophosphatidic acid receptor 1 relieves PMN recruitment in CNS via LPA1/TSP1/CXCR2 pathway and alleviates disruption on blood-brain barrier following intracerebral haemorrhage in mice.
    Title: Inhibition of lysophosphatidic acid receptor 1 relieves PMN recruitment in CNS via LPA1/TSP1/CXCR2 pathway and alleviates disruption on blood-brain barrier following intracerebral haemorrhage in mice.
  2. Lysophosphatidic acid receptor type-1 mediates brain activation in micro-positron emission tomography analysis in a fibromyalgia-like mouse model.
    Title: Lysophosphatidic acid receptor type-1 mediates brain activation in micro-positron emission tomography analysis in a fibromyalgia-like mouse model.
  3. Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.
    Title: Ablation of lysophosphatidic acid receptor 1 attenuates hypertrophic cardiomyopathy in a mouse model.
  4. LPAR1 regulates enteric nervous system function through glial signaling and contributes to chronic intestinal pseudo-obstruction.
    Title: LPAR1 regulates enteric nervous system function through glial signaling and contributes to chronic intestinal pseudo-obstruction.
  5. Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy.
    Title: Atx regulates skeletal muscle regeneration via LPAR1 and promotes hypertrophy.
  6. Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells.
    Title: Altered cleavage plane orientation with increased genomic aneuploidy produced by receptor-mediated lysophosphatidic acid (LPA) signaling in mouse cerebral cortical neural progenitor cells.
  7. Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis.
    Title: Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis.
  8. A blocking peptide stabilizes lysophosphatidic acid receptor 1 and promotes lysophosphatidic acid-induced cellular responses.
    Title: A blocking peptide stabilizes lysophosphatidic acid receptor 1 and promotes lysophosphatidic acid-induced cellular responses.
  9. Expression of lysophosphatidic acid receptor 1 in the adult female mouse pituitary gland.
    Title: Expression of lysophosphatidic acid receptor 1 in the adult female mouse pituitary gland.
  10. Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion.
    Title: Proximal tubule LPA1 and LPA2 receptors use divergent signaling pathways to additively increase profibrotic cytokine secretion.
Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC29102, 5031439C20

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lysophosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables lysophosphatidic acid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophosphatidic acid receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysophosphatidic acid receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of phospholipase C activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in activation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within bleb assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in calmodulin dependent kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to 1-oleoyl-sn-glycerol 3-phosphate ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of Rho protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smooth muscle cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell shape IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic vesicle cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with endocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lysophosphatidic acid receptor 1
Names
G-protein coupled receptor 26
LPA receptor 1
endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2
lysophosphatidic acid receptor Edg-2
rec1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290486.2 → NP_001277415.1  lysophosphatidic acid receptor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL807748
    Consensus CDS
    CCDS71391.1
    UniProtKB/Swiss-Prot
    P61793
    UniProtKB/TrEMBL
    Q544V2
    Related
    ENSMUSP00000103196.2, ENSMUST00000107570.2
    Conserved Domains (1) summary
    cd15344
    Location:32 → 304
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001421009.1 → NP_001407938.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2

  3. NM_001421010.1 → NP_001407939.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2

  4. NM_001421011.1 → NP_001407940.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2

  5. NM_001421012.1 → NP_001407941.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2

  6. NM_001421013.1 → NP_001407942.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2

  7. NM_001421014.1 → NP_001407943.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2

  8. NM_001421015.1 → NP_001407944.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2

  9. NM_001421016.1 → NP_001407945.1  lysophosphatidic acid receptor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2

  10. NM_010336.2 → NP_034466.2  lysophosphatidic acid receptor 1 isoform 1

    See identical proteins and their annotated locations for NP_034466.2

    Status: VALIDATED

    Source sequence(s)
    AK030330, AL807748, CJ152526
    Consensus CDS
    CCDS18212.1
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Related
    ENSMUSP00000103201.3, ENSMUST00000107575.9
    Conserved Domains (1) summary
    cd15344
    Location:50 → 322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

  11. NM_172989.2 → NP_766577.1  lysophosphatidic acid receptor 1 isoform 1

    See identical proteins and their annotated locations for NP_766577.1

    Status: VALIDATED

    Source sequence(s)
    AL807748, AL929390
    Consensus CDS
    CCDS18212.1
    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Related
    ENSMUSP00000052581.5, ENSMUST00000055018.11
    Conserved Domains (1) summary
    cd15344
    Location:50 → 322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    58435252..58554601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253215.2 → XP_030109075.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50 → 322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_011249932.4 → XP_011248234.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011248234.1

    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50 → 322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_036163685.1 → XP_036019578.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50 → 322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_011249930.3 → XP_011248232.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011248232.1

    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50 → 322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

  5. XM_011249933.4 → XP_011248235.1  lysophosphatidic acid receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011248235.1

    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50 → 322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors

  6. XM_036163686.1 → XP_036019579.1  lysophosphatidic acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AMJ2, O88584, P56487, P61793, P70420, Q61130
    UniProtKB/TrEMBL
    Q544V2
    Conserved Domains (1) summary
    cd15344
    Location:50 → 322
    7tmA_LPAR1_Edg2; lysophosphatidic acid receptor subtype 1 (LPAR1 or LPA1), also called endothelial differentiation gene 2 (Edg2), member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61793.1 GenPept UniProtKB/Swiss-Prot:P61793

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