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Gnrhr gonadotropin releasing hormone receptor [ Mus musculus (house mouse) ]

Gene ID: 14715, updated on 21-Apr-2024

Summary

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Official Symbol
Gnrhrprovided by MGI
Official Full Name
gonadotropin releasing hormone receptorprovided by MGI
Primary source
MGI:MGI:95790
See related
Ensembl:ENSMUSG00000029255 AllianceGenome:MGI:95790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable gonadotropin-releasing hormone receptor activity; growth hormone-releasing hormone receptor activity; and peptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and negative regulation of cell population proliferation. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adenohypophysis; jaw; mandibular process; and ovary. Used to study hypogonadotropic hypogonadism 7 with or without anosmia. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia. Orthologous to human GNRHR (gonadotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
5 E1; 5 43.56 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (86328613..86345760, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (86180754..86197901, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2747 Neighboring gene predicted gene, 24524 Neighboring gene signal transducing adaptor family member 1 Neighboring gene ubiquitin-like modifier activating enzyme 6 Neighboring gene STARR-seq mESC enhancer starr_13544 Neighboring gene STARR-positive B cell enhancer ABC_E10326 Neighboring gene transmembrane protease, serine 11c Neighboring gene STARR-seq mESC enhancer starr_13545 Neighboring gene predicted gene, 25473 Neighboring gene transmembrane protease, serine 11d Neighboring gene STARR-seq mESC enhancer starr_13546 Neighboring gene STARR-seq mESC enhancer starr_13547 Neighboring gene predicted gene, 35367 Neighboring gene STARR-seq mESC enhancer starr_13548

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling. Wang X, et al. Immunol Invest, 2022 Jul. PMID 34132158
  2. Gonadotropin-releasing hormone receptor (Gnrhr) gene knock out: Normal growth and development of sensory, motor and spatial orientation behavior but altered metabolism in neonatal and prepubertal mice. Busby ER, et al. PLoS One, 2017. PMID 28346489, Free PMC Article
  3. Histidine(7.36(305)) in the conserved peptide receptor activation domain of the gonadotropin releasing hormone receptor couples peptide binding and receptor activation. Mayevu NM, et al. Mol Cell Endocrinol, 2015 Feb 15. PMID 25583361
  4. Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy. Janovick JA, et al. Proc Natl Acad Sci U S A, 2013 Dec 24. PMID 24324164, Free PMC Article
  5. Characterization of the gonadotropin releasing hormone receptor (GnRHR) expression and activity in the female mouse ovary. Torrealday S, et al. Endocrinology, 2013 Oct. PMID 23913446, Free PMC Article

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional GnRH receptor signaling regulates striatal cholinergic neurons in neonatal but not in adult mice.
    Title: Functional GnRH receptor signaling regulates striatal cholinergic neurons in neonatal but not in adult mice.
  2. AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling.
    Title: AXL receptor tyrosine kinase modulates gonadotropin-releasing hormone receptor signaling.
  3. Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling.
    Title: Activation of Gonadotropin-releasing Hormone Receptor Impedes the Immunosuppressive Activity of Decidual Regulatory T Cells via Deactivating the Mechanistic Target of Rapamycin Signaling.
  4. Androgen receptor positively regulates gonadotropin-releasing hormone receptor in pituitary gonadotropes.
    Title: Androgen receptor positively regulates gonadotropin-releasing hormone receptor in pituitary gonadotropes.
  5. Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor.
    Title: Fyn-mediated phosphorylation of Pyk2 promotes its activation and dissociation downstream of gonadotropin-releasing hormone receptor.
  6. GnRH Antagonists Produce Differential Modulation of the Signaling Pathways Mediated by GnRH Receptors.
    Title: GnRH Antagonists Produce Differential Modulation of the Signaling Pathways Mediated by GnRH Receptors.
  7. GnRH receptorexpression levels depend on JUN and are critical for reproductive function.
    Title: GnRH Receptor Expression and Reproductive Function Depend on JUN in GnRH Receptor‒Expressing Cells.
  8. leptin's direct stimulatory actions on gonadotrope GnRHR correlate with a direct inhibition of expression of the posttranscriptional regulator MSI1. There also is a direct MSI1 interaction with 3'-UTR of Gnrhr mRNA.
    Title: Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression.
  9. the age-dependent basal and regulated Gnrhr transcription could account for the initial blockade and subsequent activation of the reproductive system during development.
    Title: The relationship between basal and regulated Gnrhr expression in rodent pituitary gonadotrophs.
  10. GnRH-GnRHR system is not essential for growth or motor/sensory/orientation behavior during the first month of life prior to puberty onset. The lack of the GnRH-GnRHR axis, however, did affect females resulting in reduced subcutaneous inguinal fat pad weight and increased glucose with possible insulin resistance.
    Title: Gonadotropin-releasing hormone receptor (Gnrhr) gene knock out: Normal growth and development of sensory, motor and spatial orientation behavior but altered metabolism in neonatal and prepubertal mice.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (6)  1 citation
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables gonadotropin-releasing hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth hormone-releasing hormone receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-hormone receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gonadotropin-releasing hormone receptor
Names
gnRH receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310651.1 → NP_001297580.1  gonadotropin-releasing hormone receptor isoform 2

    See identical proteins and their annotated locations for NP_001297580.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC107634
    Consensus CDS
    CCDS80313.1
    UniProtKB/TrEMBL
    A0A192B0U8, D3Z6P7
    Related
    ENSMUSP00000108999.2, ENSMUST00000113372.2
    Conserved Domains (1) summary
    pfam00001
    Location:76 → 174
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. NM_001310653.1 → NP_001297582.1  gonadotropin-releasing hormone receptor isoform 3

    See identical proteins and their annotated locations for NP_001297582.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks the 3' exon and its transcription extends past a splice site used in variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (3) has a distinct, shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AC107634
    Consensus CDS
    CCDS84897.1
    UniProtKB/TrEMBL
    Q6P8H4
    Related
    ENSMUSP00000092238.3, ENSMUST00000094654.3
    Conserved Domains (1) summary
    pfam00001
    Location:76 → 247
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. NM_010323.2 → NP_034453.1  gonadotropin-releasing hormone receptor isoform 1

    See identical proteins and their annotated locations for NP_034453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC107634, L01119
    Consensus CDS
    CCDS19379.1
    UniProtKB/Swiss-Prot
    Q01776, Q61611
    Related
    ENSMUSP00000031172.9, ENSMUST00000031172.9
    Conserved Domains (1) summary
    pfam00001
    Location:76 → 322
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    86328613..86345760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320667.1 → XP_017176156.1  gonadotropin-releasing hormone receptor isoform X1

    Conserved Domains (2) summary
    cd14964
    Location:37 → 68
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:36 → 174
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01776.1 GenPept UniProtKB/Swiss-Prot:Q01776

Gene LinkOut

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