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Gng8 guanine nucleotide binding protein (G protein), gamma 8 [ Mus musculus (house mouse) ]

Gene ID: 14709, updated on 21-Apr-2024

Summary

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Official Symbol
Gng8provided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), gamma 8provided by MGI
Primary source
MGI:MGI:109163
See related
Ensembl:ENSMUSG00000063594 AllianceGenome:MGI:109163
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hg3e; G(y)8
Summary
Predicted to enable G-protein beta-subunit binding activity. Acts upstream of or within cellular response to pheromone; nose development; and social behavior. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Is expressed in cochlear duct epithelium; retina; and spleen. Orthologous to human GNG8 (G protein subunit gamma 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 8.7), CNS E11.5 (RPKM 5.5) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A2; 7 9.15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16625687..16629361)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16891737..16895451)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9330104G04 gene Neighboring gene STARR-positive B cell enhancer ABC_E3701 Neighboring gene STARR-positive B cell enhancer ABC_E443 Neighboring gene dishevelled-binding antagonist of beta-catenin 3 Neighboring gene prostaglandin I receptor (IP) Neighboring gene calmodulin 3 Neighboring gene predicted gene, 45972

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Aggressive behaviour and physiological responses to pheromones are strongly impaired in mice deficient for the olfactory G-protein -subunit G8. Montani G, et al. J Physiol, 2013 Aug 15. PMID 23836683, Free PMC Article
  2. Ric-8B interacts with G alpha olf and G gamma 13 and co-localizes with G alpha olf, G beta 1 and G gamma 13 in the cilia of olfactory sensory neurons. Kerr DS, et al. Mol Cell Neurosci, 2008 Jul. PMID 18462949
  3. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. Hurowitz EH, et al. DNA Res, 2000 Apr 28. PMID 10819326
  4. Alteration of Nrp1 signaling at different stages of olfactory neuron maturation promotes glomerular shifts along distinct axes in the olfactory bulb. Assens A, et al. Development, 2016 Oct 15. PMID 27578798, Free PMC Article
  5. Characterization of the development of the mouse cochlear epithelium at the single cell level. Kolla L, et al. Nat Commun, 2020 May 13. PMID 32404924, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to pheromone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nose development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within social behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8
Names
gamma-9
guanine nucleotide binding protein (G protein), gamma 8 subunit
heterotrimeric guanine nucleotide-binding protein 3e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412471.1 → NP_001399400.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    Status: VALIDATED

    Source sequence(s)
    AC148981
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0
    Related
    ENSMUSP00000145533.2, ENSMUST00000205459.2

  2. NM_001412472.1 → NP_001399401.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    Status: VALIDATED

    Source sequence(s)
    AC148981
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0
    Related
    ENSMUSP00000145567.2, ENSMUST00000205716.2

  3. NM_001412473.1 → NP_001399402.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    Status: VALIDATED

    Source sequence(s)
    AC148981
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0

  4. NM_001412474.1 → NP_001399403.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    Status: VALIDATED

    Source sequence(s)
    AC148981
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0

  5. NM_001412475.1 → NP_001399404.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    Status: VALIDATED

    Source sequence(s)
    AC148981
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0

  6. NM_001412476.1 → NP_001399405.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    Status: VALIDATED

    Source sequence(s)
    AC148981
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0

  7. NM_001412477.1 → NP_001399406.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    Status: VALIDATED

    Source sequence(s)
    AC148981
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0

  8. NM_010320.4 → NP_034450.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

    See identical proteins and their annotated locations for NP_034450.1

    Status: VALIDATED

    Source sequence(s)
    AC148981
    Consensus CDS
    CCDS20856.1
    UniProtKB/Swiss-Prot
    P43426, P63078
    UniProtKB/TrEMBL
    Q3UMY0
    Related
    ENSMUSP00000077314.5, ENSMUST00000078182.6
    Conserved Domains (1) summary
    smart00224
    Location:8 → 70
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    16625687..16629361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63078.1 GenPept UniProtKB/Swiss-Prot:P63078

Gene LinkOut

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