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Gng12 guanine nucleotide binding protein (G protein), gamma 12 [ Mus musculus (house mouse) ]

Gene ID: 14701, updated on 13-Apr-2024

Summary

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Official Symbol
Gng12provided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), gamma 12provided by MGI
Primary source
MGI:MGI:1336171
See related
Ensembl:ENSMUSG00000036402 AllianceGenome:MGI:1336171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hg3a; 2010305F15Rik
Summary
Predicted to enable G-protein beta-subunit binding activity; PDZ domain binding activity; and phosphate ion binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to colocalize with actin filament. Is expressed in cerebral cortex subventricular zone; genitourinary system; and ventricular layer. Orthologous to human GNG12 (G protein subunit gamma 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 26.2), kidney adult (RPKM 24.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gng12 in Genome Data Viewer
Location:
6 C1; 6 30.68 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (66873381..66998345)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (66896397..67021361)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36610 Neighboring gene RIKEN cDNA 4930597O21 gene Neighboring gene predicted pseudogene 9794 Neighboring gene STARR-positive B cell enhancer mm9_chr6:66879715-66880015 Neighboring gene predicted gene, 36816 Neighboring gene STARR-seq mESC enhancer starr_16162 Neighboring gene STARR-seq mESC enhancer starr_16163 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene STARR-seq mESC enhancer starr_16164 Neighboring gene RIKEN cDNA E230016M11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:66987352-66987653 Neighboring gene predicted gene, 53333 Neighboring gene predicted gene, 25260 Neighboring gene growth arrest and DNA-damage-inducible 45 alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gng12 is a novel negative regulator of LPS-induced inflammation in the microglial cell line BV-2. Larson KC, et al. Inflamm Res, 2010 Jan. PMID 19568691
  2. Disruption of G-protein γ5 subtype causes embryonic lethality in mice. Moon AM, et al. PLoS One, 2014. PMID 24599258, Free PMC Article
  3. Lineage dynamics of murine pancreatic development at single-cell resolution. Byrnes LE, et al. Nat Commun, 2018 Sep 25. PMID 30254276, Free PMC Article
  4. Chromosomal mapping of five mouse G protein gamma subunits. Downes GB, et al. Genomics, 1999 Apr 1. PMID 10191100
  5. KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. Ahmed SM, et al. J Cell Biol, 2012 Dec 10. PMID 23209302, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables phosphate ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
colocalizes_with actin filament ISO
Inferred from Sequence Orthology
more info
  
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Names
heterotrimeric guanine nucleotide-binding protein 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177556.1 → NP_001171027.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

    See identical proteins and their annotated locations for NP_001171027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC107650
    Consensus CDS
    CCDS39502.1
    UniProtKB/Swiss-Prot
    Q544P3, Q9DAS9
    UniProtKB/TrEMBL
    A0A0N4SVT3
    Related
    ENSMUSP00000109863.2, ENSMUST00000114225.8
    Conserved Domains (1) summary
    smart00224
    Location:11 → 72
    GGL; G protein gamma subunit-like motifs

  2. NM_001177557.1 → NP_001171028.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

    See identical proteins and their annotated locations for NP_001171028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC107650, AK005561, BB851888
    Consensus CDS
    CCDS39502.1
    UniProtKB/Swiss-Prot
    Q544P3, Q9DAS9
    UniProtKB/TrEMBL
    A0A0N4SVT3
    Related
    ENSMUSP00000109866.2, ENSMUST00000114228.8
    Conserved Domains (1) summary
    smart00224
    Location:11 → 72
    GGL; G protein gamma subunit-like motifs

  3. NM_001177558.1 → NP_001171029.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

    See identical proteins and their annotated locations for NP_001171029.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC107650
    Consensus CDS
    CCDS39502.1
    UniProtKB/Swiss-Prot
    Q544P3, Q9DAS9
    UniProtKB/TrEMBL
    A0A0N4SVT3
    Related
    ENSMUSP00000109860.2, ENSMUST00000114222.4
    Conserved Domains (1) summary
    smart00224
    Location:11 → 72
    GGL; G protein gamma subunit-like motifs

  4. NM_001177559.1 → NP_001171030.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

    See identical proteins and their annotated locations for NP_001171030.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC107650
    Consensus CDS
    CCDS39502.1
    UniProtKB/Swiss-Prot
    Q544P3, Q9DAS9
    UniProtKB/TrEMBL
    A0A0N4SVT3
    Related
    ENSMUSP00000109865.2, ENSMUST00000114227.8
    Conserved Domains (1) summary
    smart00224
    Location:11 → 72
    GGL; G protein gamma subunit-like motifs

  5. NM_001177560.1 → NP_001171031.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

    See identical proteins and their annotated locations for NP_001171031.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC107650, AK162342, BB851888
    Consensus CDS
    CCDS39502.1
    UniProtKB/Swiss-Prot
    Q544P3, Q9DAS9
    UniProtKB/TrEMBL
    A0A0N4SVT3
    Related
    ENSMUSP00000109864.2, ENSMUST00000114226.8
    Conserved Domains (1) summary
    smart00224
    Location:11 → 72
    GGL; G protein gamma subunit-like motifs

  6. NM_025278.5 → NP_079554.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

    See identical proteins and their annotated locations for NP_079554.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC107650, AK159872, BB851888
    Consensus CDS
    CCDS39502.1
    UniProtKB/Swiss-Prot
    Q544P3, Q9DAS9
    UniProtKB/TrEMBL
    A0A0N4SVT3
    Related
    ENSMUSP00000046557.7, ENSMUST00000043148.13
    Conserved Domains (1) summary
    smart00224
    Location:11 → 72
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    66873381..66998345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165848.1 → XP_036021741.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

    UniProtKB/Swiss-Prot
    Q544P3, Q9DAS9
    UniProtKB/TrEMBL
    A0A0N4SVT3
    Related
    ENSMUSP00000109862.2, ENSMUST00000114224.8
    Conserved Domains (1) summary
    smart00224
    Location:11 → 72
    GGL; G protein gamma subunit-like motifs

  2. XM_036165846.1 → XP_036021739.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

    UniProtKB/Swiss-Prot
    Q544P3, Q9DAS9
    UniProtKB/TrEMBL
    A0A0N4SVT3
    Conserved Domains (1) summary
    smart00224
    Location:11 → 72
    GGL; G protein gamma subunit-like motifs

  3. XM_036165845.1 → XP_036021738.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

    UniProtKB/Swiss-Prot
    Q544P3, Q9DAS9
    UniProtKB/TrEMBL
    A0A0N4SVT3
    Conserved Domains (1) summary
    smart00224
    Location:11 → 72
    GGL; G protein gamma subunit-like motifs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAS9.3 GenPept UniProtKB/Swiss-Prot:Q9DAS9

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