Gna12 guanine nucleotide binding protein, alpha 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gna12provided by MGI
Official Full Name: guanine nucleotide binding protein, alpha 12provided by MGI
Primary source: MGI:MGI:95767
See related: Ensembl:ENSMUSG00000000149 AllianceGenome:MGI:95767
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Galpha12
Summary: Predicted to enable D5 dopamine receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including multicellular organism aging; regulation of TOR signaling; and regulation of fibroblast migration. Acts upstream of or within several processes, including Rho protein signal transduction; embryonic digit morphogenesis; and regulation of cell shape. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in brush border membrane. Is expressed in several structures, including branchial arch; central nervous system; female reproductive system; heart; and retina. Orthologous to human GNA12 (G protein subunit alpha 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 67.3), ovary adult (RPKM 61.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 79.3 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (140745699..140816186, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (140759944..140830431, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Galpha12 and endoplasmic reticulum stress-mediated pyroptosis in a single cycle of dextran sulfate-induced mouse colitis.
Title: Gα12 and endoplasmic reticulum stress-mediated pyroptosis in a single cycle of dextran sulfate-induced mouse colitis.
Here, the authors show that small arteries from mice with smooth muscle-specific loss of G12/G13 or the Rho guanine nucleotide exchange factor ARHGEF12 have lost myogenic vasoconstriction.
Title: Myogenic vasoconstriction requires G(12)/G(13) and LARG to maintain local and systemic vascular resistance.
results demonstrate that Galpha12 regulates SIRT1-dependent mitochondrial respiration through HIF-1alpha-dependent USP22 induction, identifying Galpha12 as an upstream molecule that contributes to the regulation of mitochondrial energy expenditure.
Title: Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration.
The results of this study suggest that a balance in the expression of Go1alpha and Go2alpha sustains normal motor function. Deletion of either splice variant results in divergent behavioural and molecular alterations in the striatal dopaminergic system.
Title: Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system.
Galpha12 plays a role in differentiation through NFATc1 and in cell migration and resorption activity through RhoA during osteoclastogenesis.
Title: Gα12 regulates osteoclastogenesis by modulating NFATc1 expression.
Galpha12 is required for the development of kidney cysts induced by Pkd1 mutation in mouse autosomal dominant polycystic kidney disease.
Title: Gα12 is required for renal cystogenesis induced by Pkd1 inactivation.
Our data reveal a previously unknown role for Galpha12 in regulating efferocytosis and that renal tubular epithelial cells require KIM-1 to mediate this process.
Title: G protein α(12) (Gα(12)) is a negative regulator of kidney injury molecule-1-mediated efferocytosis.
Selective inhibition of G12/13 signaling in macrophages can augment atheroprotective B-cell populations and ameliorate atherosclerosis.
Title: S1P2/G12/13 Signaling Negatively Regulates Macrophage Activation and Indirectly Shapes the Atheroprotective B1-Cell Population.
Gpr56 regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA
Title: The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA.
results suggest that KIM-1 is an endogenous protective mechanism against renal ischemia-reperfusion injury through inhibition of Galpha12.
Title: Kidney injury molecule-1 protects against Gα12 activation and tissue damage in renal ischemia-reperfusion injury.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gna12 (e-PCR), detects polymorphism
- UniSTS:496664

M63659 (e-PCR)
- UniSTS:163377

D5Mit247 (e-PCR), detects polymorphism
- UniSTS:130380

Gna12 (e-PCR), detects polymorphism
- UniSTS:256614

D5Mit327 (e-PCR), detects polymorphism
- UniSTS:130470

NoName (e-PCR)
- UniSTS:489132

Gna12 (e-PCR), detects polymorphism
- UniSTS:496818

RH144209 (e-PCR)
- UniSTS:233454

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D5 dopamine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables D5 dopamine receptor binding	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G-protein beta/gamma-subunit complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables guanyl nucleotide binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within embryonic digit morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of cell shape	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in brush border membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	TAS Traceable Author Statement more info	PubMed
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: guanine nucleotide-binding protein subunit alpha-12

Names: G-protein subunit alpha-12; g alpha-12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.