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Gna11 guanine nucleotide binding protein, alpha 11 [ Mus musculus (house mouse) ]

Gene ID: 14672, updated on 4-Jan-2025

Summary

Official Symbol
Gna11provided by MGI
Official Full Name
guanine nucleotide binding protein, alpha 11provided by MGI
Primary source
MGI:MGI:95766
See related
Ensembl:ENSMUSG00000034781 AllianceGenome:MGI:95766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dsk7; Hg1k; E430025L19; g alpha-11
Summary
Enables G protein activity and enzyme regulator activity. Involved in several processes, including G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion. Acts upstream of or within several processes, including cellular response to pH; phospholipase C-activating dopamine receptor signaling pathway; and regulation of melanocyte differentiation. Is active in plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; cardiovascular system; central nervous system; and genitourinary system. Used to study autosomal dominant hypocalcemia 2. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia 2 and familial hypocalciuric hypercalcemia 2. Orthologous to human GNA11 (G protein subunit alpha 11). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in duodenum adult (RPKM 262.5), small intestine adult (RPKM 254.3) and 24 other tissues See more
Orthologs
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Genomic context

See Gna11 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81364558..81380996, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81528724..81545162, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate receptor 4 Neighboring gene guanine nucleotide binding protein, alpha 15 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80973115-80973298 Neighboring gene STARR-positive B cell enhancer ABC_E11449 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80989510-80989711 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:81014523-81014724 Neighboring gene TLE family member 5, transcriptional modulator Neighboring gene STARR-positive B cell enhancer ABC_E3902 Neighboring gene predicted gene, 31936

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity PubMed 
enables G protein activity PubMed 
enables G protein-coupled receptor binding  
enables G protein-coupled receptor binding  
enables G-protein beta/gamma-subunit complex binding  
enables G-protein beta/gamma-subunit complex binding  
enables GTP binding  
enables GTPase activity  
enables GTPase activity PubMed 
enables GTPase activity PubMed 
enables alkylglycerophosphoethanolamine phosphodiesterase activity PubMed 
enables enzyme regulator activity PubMed 
enables enzyme regulator activity PubMed 
enables metal ion binding  
enables protein binding PubMed 
enables protein-containing complex binding  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway PubMed 
involved_in action potential  
acts_upstream_of_or_within action potential PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway  
acts_upstream_of_or_within cellular response to pH PubMed 
involved_in cranial skeletal system development PubMed 
acts_upstream_of_or_within developmental pigmentation PubMed 
involved_in endothelin receptor signaling pathway PubMed 
NOT acts_upstream_of_or_within glutamate receptor signaling pathway PubMed 
acts_upstream_of_or_within heart development PubMed 
involved_in ion channel modulating, G protein-coupled receptor signaling pathway PubMed 
involved_in ligand-gated ion channel signaling pathway PubMed 
involved_in ligand-gated ion channel signaling pathway PubMed 
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
involved_in phospholipase C-activating dopamine receptor signaling pathway  
acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway PubMed 
involved_in positive regulation of insulin secretion PubMed 
involved_in positive regulation of insulin secretion PubMed 
involved_in regulation of blood pressure PubMed 
acts_upstream_of_or_within regulation of melanocyte differentiation PubMed 
acts_upstream_of_or_within skeletal system development PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
part_of heterotrimeric G-protein complex  
part_of heterotrimeric G-protein complex PubMed 
part_of heterotrimeric G-protein complex PubMed 
part_of heterotrimeric G-protein complex PubMed 
is_active_in plasma membrane PubMed 
is_active_in plasma membrane PubMed 
located_in synapse  

General protein information

Preferred Names
guanine nucleotide-binding protein subunit alpha-11
Names
G-protein subunit alpha-11
heterotrimeric guanine nucleotide-binding protein 1k

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010301.4NP_034431.1  guanine nucleotide-binding protein subunit alpha-11

    See identical proteins and their annotated locations for NP_034431.1

    Status: VALIDATED

    Source sequence(s)
    AC159474, AK143685, CD741377
    Consensus CDS
    CCDS24061.1
    UniProtKB/Swiss-Prot
    P21278, Q61939
    UniProtKB/TrEMBL
    Q3UPA1, Q91X95
    Related
    ENSMUSP00000043190.6, ENSMUST00000043604.6
    Conserved Domains (1) summary
    cd00066
    Location:40353
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    81364558..81380996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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