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CSRP2 cysteine and glycine rich protein 2 [ Homo sapiens (human) ]

Gene ID: 1466, updated on 3-Apr-2024

Summary

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Official Symbol
CSRP2provided by HGNC
Official Full Name
cysteine and glycine rich protein 2provided by HGNC
Primary source
HGNC:HGNC:2470
See related
Ensembl:ENSG00000175183 MIM:601871; AllianceGenome:HGNC:2470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRP2; LMO5; SmLIM
Summary
CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in esophagus (RPKM 37.2), placenta (RPKM 35.3) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
12q21.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (76858709..76879019, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (76836580..76856889, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (77252489..77272799, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6679 Neighboring gene Sharpr-MPRA regulatory region 20 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:77158059-77158901 Neighboring gene RWD domain containing 1 pseudogene 3 Neighboring gene zinc finger DHHC-type palmitoyltransferase 17 Neighboring gene MPRA-validated peak1846 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4673 Neighboring gene NANOG hESC enhancer GRCh37_chr12:77268223-77268724 Neighboring gene uncharacterized LOC124902971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4675 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:77313616-77314124 Neighboring gene Sharpr-MPRA regulatory region 9474 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:77329846-77331045 Neighboring gene NANOG hESC enhancer GRCh37_chr12:77358407-77359020 Neighboring gene RAN binding protein 1 pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:77425832-77427031 Neighboring gene E2F transcription factor 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4676 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:77459297-77460003

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cysteine and glycine-rich protein 2 (CSRP2) transcript levels correlate with leukemia relapse and leukemia-free survival in adults with B-cell acute lymphoblastic leukemia and normal cytogenetics. Wang SJ, et al. Oncotarget, 2017 May 30. PMID 28415593, Free PMC Article
  2. Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2. Hoffmann C, et al. Sci Rep, 2018 Jul 5. PMID 29976963, Free PMC Article
  3. Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines. Stearns ME, et al. Mol Cancer Res, 2003 Jul. PMID 12861049
  4. Role of CRP2-MRTF interaction in functions of myofibroblasts. Hayashi K, et al. Cell Struct Funct, 2023. PMID 37164693, Free PMC Article
  5. CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways. Chen L, et al. Theranostics, 2020. PMID 33042270, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Significance of the p38MAPK-CRP2 axis in myofibroblastic phenotypic transition.
    Title: Significance of the p38MAPK-CRP2 axis in myofibroblastic phenotypic transition.
  2. Role of CRP2-MRTF interaction in functions of myofibroblasts.
    Title: Role of CRP2-MRTF interaction in functions of myofibroblasts.
  3. CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways.
    Title: CSRP2 suppresses colorectal cancer progression via p130Cas/Rac1 axis-meditated ERK, PAK, and HIPPO signaling pathways.
  4. Study showed that CSRP2, an invadopodial actin bundling protein, is upregulated by hypoxia in various breast cancer cell lines, as well as in pre-clinical and clinical breast tumor specimens and functionally characterized two hypoxia responsive elements within the proximal promoter of CSRP2 gene which are targeted by hypoxia-inducible factor-1 (HIF-1) and required for promoter transactivation in response to hypoxia.
    Title: Hypoxia promotes breast cancer cell invasion through HIF-1α-mediated up-regulation of the invadopodial actin bundling protein CSRP2.
  5. CSRP2 promoted cell proliferation, cell-cycle progression, in vitro colony formation and cell migration ability. Abnormal CSRP2 expression was associated with resistance to chemotherapy; sensitivity was restored by down-regulating CSRP2 expression.
    Title: Cysteine and glycine-rich protein 2 (CSRP2) transcript levels correlate with leukemia relapse and leukemia-free survival in adults with B-cell acute lymphoblastic leukemia and normal cytogenetics.
  6. the effect of proteasome inhibition on IL-10 activation of the IL-10E1 pathway [Il-10E1]
    Title: Interleukin-10 activation of the interleukin-10E1 pathway and tissue inhibitor of metalloproteinase-1 expression is enhanced by proteasome inhibitors in primary prostate tumor lines.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actinin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of muscle IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
cysteine and glycine-rich protein 2
Names
LIM domain only 5, smooth muscle
LIM domain only protein 5
LMO-5
cysteine-rich protein 2
epididymis secretory sperm binding protein
smooth muscle cell LIM protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300965.2 → NP_001287894.1  cysteine and glycine-rich protein 2 isoform b

    See identical proteins and their annotated locations for NP_001287894.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes isoform b. Variants 1-5 all encode the same isoform (b).
    Source sequence(s)
    AC124784, BC000992, BX461295, CN408330
    Consensus CDS
    CCDS9015.1
    UniProtKB/Swiss-Prot
    Q16527, Q93030
    UniProtKB/TrEMBL
    A0A024RBB5, F8VQR7
    Related
    ENSP00000450056.1, ENST00000546966.5
    Conserved Domains (2) summary
    cd09480
    Location:9 → 63
    LIM1_CRP2; The first LIM domain of Cysteine Rich Protein 2 (CRP2)
    cd09840
    Location:119 → 172
    LIM2_CRP2; The second LIM domain of Cysteine Rich Protein 2 (CRP2)

  2. NM_001321.3 → NP_001312.1  cysteine and glycine-rich protein 2 isoform b

    See identical proteins and their annotated locations for NP_001312.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform b. Variants 1-5 all encode the same isoform (b).
    Source sequence(s)
    AC124784, BC000992, BX461295
    Consensus CDS
    CCDS9015.1
    UniProtKB/Swiss-Prot
    Q16527, Q93030
    UniProtKB/TrEMBL
    A0A024RBB5, F8VQR7
    Related
    ENSP00000310901.5, ENST00000311083.10
    Conserved Domains (2) summary
    cd09480
    Location:9 → 63
    LIM1_CRP2; The first LIM domain of Cysteine Rich Protein 2 (CRP2)
    cd09840
    Location:119 → 172
    LIM2_CRP2; The second LIM domain of Cysteine Rich Protein 2 (CRP2)

  3. NM_001413535.1 → NP_001400464.1  cysteine and glycine-rich protein 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC124784
    UniProtKB/Swiss-Prot
    Q16527, Q93030
    UniProtKB/TrEMBL
    A0A024RBB5

  4. NM_001413537.1 → NP_001400466.1  cysteine and glycine-rich protein 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC124784
    UniProtKB/Swiss-Prot
    Q16527, Q93030
    UniProtKB/TrEMBL
    A0A024RBB5

  5. NM_001413538.1 → NP_001400467.1  cysteine and glycine-rich protein 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC124784
    UniProtKB/Swiss-Prot
    Q16527, Q93030
    UniProtKB/TrEMBL
    A0A024RBB5

  6. NM_001413539.1 → NP_001400468.1  cysteine and glycine-rich protein 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC124784
    UniProtKB/TrEMBL
    F8VW96
    Related
    ENSP00000449824.1, ENST00000552330.5

  7. NM_001413540.1 → NP_001400469.1  cysteine and glycine-rich protein 2 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC124784

  8. NM_001413541.1 → NP_001400470.1  cysteine and glycine-rich protein 2 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC124784

  9. NM_001413542.1 → NP_001400471.1  cysteine and glycine-rich protein 2 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC124784

RNA

  1. NR_182159.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC124784

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    76858709..76879019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428395.1 → XP_047284351.1  cysteine and glycine-rich protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q16527, Q93030
    UniProtKB/TrEMBL
    A0A024RBB5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    76836580..76856889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371216.1 → XP_054227191.1  cysteine and glycine-rich protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q16527, Q93030
    UniProtKB/TrEMBL
    A0A024RBB5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16527.3 GenPept UniProtKB/Swiss-Prot:Q16527

Gene LinkOut

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