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Gpr83 G protein-coupled receptor 83 [ Mus musculus (house mouse) ]

Gene ID: 14608, updated on 21-Apr-2024

Summary

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Official Symbol
Gpr83provided by MGI
Official Full Name
G protein-coupled receptor 83provided by MGI
Primary source
MGI:MGI:95712
See related
Ensembl:ENSMUSG00000031932 AllianceGenome:MGI:95712
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gir; RP39; RP82; Gpr72; RP105
Summary
Predicted to enable neuropeptide receptor activity. Acts upstream of or within response to glucocorticoid. Located in non-motile cilium. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and pectoralis. Orthologous to human GPR83 (G protein-coupled receptor 83). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 4.8), frontal lobe adult (RPKM 3.6) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A2; 9 4.4 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (14771038..14782085)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (14859880..14870789)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23360 Neighboring gene MRE11A homolog A, double strand break repair nuclease Neighboring gene macrophage migration inhibitory factor, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_23361 Neighboring gene IZUMO1 receptor, JUNO Neighboring gene STARR-seq mESC enhancer starr_23362 Neighboring gene coenzyme Q10 homolog B pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gpr83 Tunes Nociceptor Function, Controlling Pain. Kim Y, et al. Neurotherapeutics, 2023 Jan. PMID 36352334, Free PMC Article
  2. PEN Receptor GPR83 in Anxiety-Like Behaviors: Differential Regulation in Global vs Amygdalar Knockdown. Fakira AK, et al. Front Neurosci, 2021. PMID 34512237, Free PMC Article
  3. The role of the neuropeptide PEN receptor, GPR83, in the reward pathway: Relationship to sex-differences. Fakira AK, et al. Neuropharmacology, 2019 Oct. PMID 31199956, Free PMC Article
  4. The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist. Müller A, et al. BMC Res Notes, 2014 Dec 16. PMID 25516095, Free PMC Article
  5. G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity. Müller A, et al. PLoS One, 2013. PMID 23335960, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gpr83 Tunes Nociceptor Function, Controlling Pain.
    Title: Gpr83 Tunes Nociceptor Function, Controlling Pain.
  2. findings detect GPR83 expression in the reward-pathway, and show its involvement in dopamine release and morphine reward-learning.
    Title: The role of the neuropeptide PEN receptor, GPR83, in the reward pathway: Relationship to sex-differences.
  3. this study identified a receptor for PEN in mouse hypothalamus and Neuro2A cellsit. It is GPR83.
    Title: Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.
  4. Data indicate that the extracellular portion of G-protein coupled receptor 83 (GPR83) has a strong regulatory function on this receptor.
    Title: The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist.
  5. Gpr83 modulates ghrelin action and Gpr83 regulates systemic metabolism through other ghrelin-independent pathways.
    Title: The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.
  6. GIR -/- mice show increased preference for sucrose, delayed acquisition of spatial learning and insensitivity to the anxiogenic effects of restraint stress.
    Title: Attenuated stress-evoked anxiety, increased sucrose preference and delayed spatial learning in glucocorticoid-induced receptor-deficient mice.
  7. GPR83 may participate in central thermoregulation and the central control of circulating adiponectin.
    Title: Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin.
  8. These results demonstrate that GPR83 is dispensable for Treg-cell development and function.
    Title: G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells.
  9. Gpr83 is critically involved in the peripheral conversion of Foxp3-negative to Foxp3-expressing regulatory T cells in vivo.
    Title: G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neuropeptide Y receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to glucocorticoid IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cilium ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
G-protein coupled receptor 83
Names
glucocorticoid-induced receptor
probable G-protein coupled receptor 83

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310734.1 → NP_001297663.1  G-protein coupled receptor 83 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001297663.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC136743, AK030359, AK035356, AK041527
    Consensus CDS
    CCDS80959.1
    UniProtKB/TrEMBL
    Q544C4
    Related
    ENSMUSP00000111287.3, ENSMUST00000115624.3
    Conserved Domains (1) summary
    pfam00001
    Location:88 → 303
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. NM_010287.3 → NP_034417.1  G-protein coupled receptor 83 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034417.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK030359, AK035356, AK041527, AK081276
    Consensus CDS
    CCDS22829.1
    UniProtKB/Swiss-Prot
    P30731, Q542Q9, Q544C4
    UniProtKB/TrEMBL
    Q9EPJ7
    Related
    ENSMUSP00000034408.6, ENSMUST00000034408.12
    Conserved Domains (2) summary
    pfam00001
    Location:88 → 345
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:78 → 225
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    14771038..14782085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244058.2 → XP_030099918.1  G-protein coupled receptor 83 isoform X1

    UniProtKB/TrEMBL
    Q9EPJ7
    Conserved Domains (1) summary
    cd15389
    Location:72 → 413
    7tmA_GPR83; G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_006510017.4 → XP_006510080.1  G-protein coupled receptor 83 isoform X2

    UniProtKB/TrEMBL
    Q9EPJ7
    Conserved Domains (1) summary
    cd15389
    Location:72 → 376
    7tmA_GPR83; G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30731.2 GenPept UniProtKB/Swiss-Prot:P30731

Gene LinkOut

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