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CSNK2A1 casein kinase 2 alpha 1 [ Homo sapiens (human) ]

Gene ID: 1457, updated on 13-Apr-2024

Summary

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Official Symbol
CSNK2A1provided by HGNC
Official Full Name
casein kinase 2 alpha 1provided by HGNC
Primary source
HGNC:HGNC:2457
See related
Ensembl:ENSG00000101266 MIM:115440; AllianceGenome:HGNC:2457
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CKII; Cka1; Cka2; CK2A1; OCNDS
Summary
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythm. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. Multiple transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Apr 2018]
Expression
Ubiquitous expression in testis (RPKM 33.5), brain (RPKM 25.8) and 25 other tissues See more
Orthologs
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Genomic context

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See CSNK2A1 in Genome Data Viewer
Location:
20p13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (472498..543790, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (516232..587494, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (453142..524434, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:388888-389530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:389531-390171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12576 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:410614-411114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:411115-411615 Neighboring gene RANBP2-type and C3HC4-type zinc finger containing 1 Neighboring gene TBC1 domain family member 20 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:442560-442708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12578 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:456844-457048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:522754-523447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12579 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:524141-524834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:552949-553709 Neighboring gene Sharpr-MPRA regulatory region 14258 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:572175-572398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:591860-592360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:592361-592861 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:596343-597542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:601772-602601 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:602602-603430 Neighboring gene transcription factor 15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:614811-615388 Neighboring gene uncharacterized LOC107985423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12582 Neighboring gene sulfiredoxin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Okur-Chung Neurodevelopmental Syndrome. Adam MP, et al. , 1993. PMID 35679446
  2. Contribution of the CK2 Catalytic Isoforms α and α' to the Glycolytic Phenotype of Tumor Cells. Zonta F, et al. Cells, 2021 Jan 18. PMID 33477590, Free PMC Article
  3. Heterozygous de novo variants in CSNK1G1 are associated with syndromic developmental delay and autism spectrum disorder. Gold NB, et al. Clin Genet, 2020 Dec. PMID 33009664
  4. Coordinated targeting of CK2 and KIT in gastrointestinal stromal tumours. Huang M, et al. Br J Cancer, 2020 Feb. PMID 31776458, Free PMC Article
  5. Okur-Chung neurodevelopmental syndrome in a patient from Spain. Martinez-Monseny AF, et al. Am J Med Genet A, 2020 Jan. PMID 31729156

See all (867) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Okur-Chung neurodevelopmental syndrome: Implications for phenotype and genotype expansion.
    Title: Okur-Chung neurodevelopmental syndrome: Implications for phenotype and genotype expansion.
  2. CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy.
    Title: CSNK2A1 confers gemcitabine resistance to pancreatic ductal adenocarcinoma via inducing autophagy.
  3. A CK2 and SUMO-dependent, PML NB-involved regulatory mechanism controlling BLM ubiquitination and G-quadruplex resolution.
    Title: A CK2 and SUMO-dependent, PML NB-involved regulatory mechanism controlling BLM ubiquitination and G-quadruplex resolution.
  4. SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways.
    Title: SLC39A10 promotes malignant phenotypes of gastric cancer cells by activating the CK2-mediated MAPK/ERK and PI3K/AKT pathways.
  5. P300 increases CSNK2A1 expression which accelerates colorectal cancer progression through activation of the PI3K-AKT-mTOR axis.
    Title: P300 increases CSNK2A1 expression which accelerates colorectal cancer progression through activation of the PI3K-AKT-mTOR axis.
  6. CKII Control of Axonal Plasticity Is Mediated by Mitochondrial Ca[2+] via Mitochondrial NCLX.
    Title: CKII Control of Axonal Plasticity Is Mediated by Mitochondrial Ca(2+) via Mitochondrial NCLX.
  7. Inhibition of CK2 mitigates Alzheimer's tau pathology by preventing NR2B synaptic mislocalization.
    Title: Inhibition of CK2 mitigates Alzheimer's tau pathology by preventing NR2B synaptic mislocalization.
  8. Long Non-Coding RNA KCNQ1OT1 Regulates Protein Kinase CK2 Via miR-760 in Senescence and Calorie Restriction.
    Title: Long Non-Coding RNA KCNQ1OT1 Regulates Protein Kinase CK2 Via miR-760 in Senescence and Calorie Restriction.
  9. Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity.
    Title: Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity.
  10. CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle.
    Title: CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle.
Submit: New GeneRIF Correction See all GeneRIFs (302)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Okur-Chung neurodevelopmental syndrome
MedGen: C4310739 OMIM: 617062 GeneReviews: Okur-Chung Neurodevelopmental Syndrome
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, casein kinase 2 alpha 1 polypeptide (CSNK2A1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with CSNK2A1 is decreased by RRE PubMed
rev CK2 modulates the interaction of Rev with nucleolar phosphoprotein B23 by phosphorylating B23 PubMed
rev Rev activates CK2, an effect hypothesized to promote HIV-1 replication PubMed
rev phosphorylation of Rev is dependent on the beta subunit of CK2 PubMed
rev amino acids 35-50 of Rev are involved with electrostatic interactions with CK2 while amino acids 12-24 of Rev are involved with hydrophobic interactions PubMed
rev CK2 phosphorylates Rev on Serine 5 and Serine 8 PubMed
Vpu vpu Phosphorylation of HIV-1 Vpu by casein kinase 2 is required for Vpu-mediated degradation of CD4, regulation of HIV-1 envelope secretion and control of syncytium formation PubMed
vpu The HIV-1 Vpu protein is phosphorylated by casein kinase 2 on serine amino acids 52 and 56 PubMed
matrix gag CK2 has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
retropepsin gag-pol Purified recombinant HIV-1 protease (rPR) is phosphorylated by casein kinase II, and the activity of rPR is stimulated approximately 2.9-fold as a result of this phosphorylation PubMed
reverse transcriptase gag-pol Casein kinase II phosphorylates HIV-1 RT p66 and p51 in human cells PubMed
gag-pol Phosphorylation of HIV-1 RT p66 and p51 by Casein kinase II mediates the stimulation of RNA-dependent DNA polymerase (RDDP) activity in vitro PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Hsp90 protein binding TAS
Traceable Author Statement
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in chaperone-mediated protein folding TAS
Traceable Author Statement
more info
 PubMed 
involved_in double-strand break repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of ubiquitin-dependent protein catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of aggrephagy IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of chromosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in symbiont-mediated disruption of host cell PML body IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in PML body IDA
Inferred from Direct Assay
more info
 PubMed 
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Sin3-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein kinase CK2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein kinase CK2 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of protein kinase CK2 complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
casein kinase II subunit alpha
Names
CK2 catalytic subunit alpha
casein kinase 2, alpha 1 polypeptide
casein kinase II alpha 1 polypeptide pseudogene
casein kinase II alpha 1 subunit
protein kinase CK2
NP_001349699.1
NP_001349700.1
NP_001886.1
NP_808227.1
NP_808228.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011970.2 RefSeqGene

    Range
    5049..76341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001362770.2 → NP_001349699.1  casein kinase II subunit alpha isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same protein.
    Source sequence(s)
    AL049761
    Consensus CDS
    CCDS13003.1
    UniProtKB/Swiss-Prot
    B4DYS6, D3DVV8, P19138, P20426, P68400, Q14013, Q5U065
    UniProtKB/TrEMBL
    B2R6D7, B5BUH5
    Related
    ENSP00000495998.1, ENST00000645623.1
    Conserved Domains (1) summary
    cd14132
    Location:20 → 325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  2. NM_001362771.2 → NP_001349700.1  casein kinase II subunit alpha isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' and 3' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same protein.
    Source sequence(s)
    AL049761
    Consensus CDS
    CCDS13003.1
    UniProtKB/Swiss-Prot
    B4DYS6, D3DVV8, P19138, P20426, P68400, Q14013, Q5U065
    UniProtKB/TrEMBL
    B2R6D7, B5BUH5
    Related
    ENSP00000495248.1, ENST00000643660.1
    Conserved Domains (1) summary
    cd14132
    Location:20 → 325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  3. NM_001895.4 → NP_001886.1  casein kinase II subunit alpha isoform a

    See identical proteins and their annotated locations for NP_001886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4 and 5 encode the same protein.
    Source sequence(s)
    AL049761, AU133318, BC053532, M55265
    Consensus CDS
    CCDS13003.1
    UniProtKB/Swiss-Prot
    B4DYS6, D3DVV8, P19138, P20426, P68400, Q14013, Q5U065
    UniProtKB/TrEMBL
    B2R6D7, B5BUH5
    Related
    ENSP00000496569.1, ENST00000646561.1
    Conserved Domains (1) summary
    cd14132
    Location:20 → 325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  4. NM_177559.3 → NP_808227.1  casein kinase II subunit alpha isoform a

    See identical proteins and their annotated locations for NP_808227.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 4 and 5 encode the same protein.
    Source sequence(s)
    AL049761, AU132198, BC053532, M55265
    Consensus CDS
    CCDS13003.1
    UniProtKB/Swiss-Prot
    B4DYS6, D3DVV8, P19138, P20426, P68400, Q14013, Q5U065
    UniProtKB/TrEMBL
    B2R6D7, B5BUH5
    Related
    ENSP00000217244.3, ENST00000217244.9
    Conserved Domains (1) summary
    cd14132
    Location:20 → 325
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  5. NM_177560.3 → NP_808228.1  casein kinase II subunit alpha isoform b

    See identical proteins and their annotated locations for NP_808228.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR as well as the first coding exon compared to variant 1, resulting in an isoform (b) which is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AL049761, AU132198, AY735339, BC053532, M55265
    Consensus CDS
    CCDS13004.1
    UniProtKB/Swiss-Prot
    P68400
    Related
    ENSP00000339247.6, ENST00000349736.10
    Conserved Domains (1) summary
    cd14132
    Location:1 → 189
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    472498..543790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    516232..587494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P68400.1 GenPept UniProtKB/Swiss-Prot:P68400

Gene LinkOut

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