Galr3 galanin receptor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Galr3provided by MGI
Official Full Name: galanin receptor 3provided by MGI
Primary source: MGI:MGI:1329003
See related: Ensembl:ENSMUSG00000114755 AllianceGenome:MGI:1329003
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Galnr3
Summary: Predicted to enable galanin receptor activity and peptide hormone binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within signal transduction. Located in non-motile cilium. Orthologous to human GALR3 (galanin receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 6.2), small intestine adult (RPKM 2.3) and 11 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 15 E1; 15 37.7 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (78926085..78927758)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (79041885..79043558)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Galanin receptor 3 attenuates inflammation and influences the gut microbiota in an experimental murine colitis model.
Title: Galanin receptor 3 attenuates inflammation and influences the gut microbiota in an experimental murine colitis model.
Palmitate and Nitric Oxide Regulate the Expression of Spexin and Galanin Receptors 2 and 3 in Hypothalamic Neurons.
Title: Palmitate and Nitric Oxide Regulate the Expression of Spexin and Galanin Receptors 2 and 3 in Hypothalamic Neurons.
Involvement of Neuropeptide Galanin Receptors 2 and 3 in Learning, Memory and Anxiety in Aging Mice.
Title: Involvement of Neuropeptide Galanin Receptors 2 and 3 in Learning, Memory and Anxiety in Aging Mice.
molecular structures that confer ligand selectivity for galanin type II and III receptors
Title: Exploring the molecular structures that confer ligand selectivity for galanin type II and III receptors.
In a murine psoriasis model C57/BL6 mice lacking galanin receptor 3 display a milder course of psoriasis upon imiquimod treatment, leading to decreased disease severity, delayed neo-vascularization, reduced infiltration of neutrophils, and significantly lower levels of proinflammatory cytokines compared with wild-type mice.
Title: Lack of Galanin Receptor 3 Alleviates Psoriasis by Altering Vascularization, Immune Cell Infiltration, and Cytokine Expression.
does not influence oxazolone-induced contact dermatitis
Title: Galanin 3 receptor-deficient mice show no alteration in the oxazolone-induced contact dermatitis phenotype.
After arthritis induction, GAL3 knockouts demonstrated increased clinical disease severity and earlier hindlimb edema than wild types.
Title: Lack of Galanin 3 Receptor Aggravates Murine Autoimmune Arthritis.
Our data suggest involvement of GAL3 receptors in GAL-mediated effects on mood, anxiety, and behavior.
Title: GAL3 receptor KO mice exhibit an anxiety-like phenotype.
This study shows GalR3-mediated neuroprotection, supporting a potential future therapeutic development, based on GalR3 activation, for the treatment of brain disorders
Title: GalR3 activation promotes adult neural stem cell survival in response to a diabetic milieu.
Data show that galanin receptor mRNA and protein are expressed in mouse pancreas, with GALR3 mRNA predominating.
Title: Galanin receptor 3--a potential target for acute pancreatitis therapy.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:494615

NoName (e-PCR)
- UniSTS:490685

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables galanin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables galanin receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in galanin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase activity	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cilium	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: galanin receptor type 3

Names: GAL3-R; GALR-3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015738.2 → NP_056553.2 galanin receptor type 3

See identical proteins and their annotated locations for NP_056553.2

Status: VALIDATED

Source sequence(s)

AL589670, BC131952

Consensus CDS

CCDS27631.1

UniProtKB/Swiss-Prot

A2RS28, E9QPX7, O88853

Related

ENSMUSP00000060517.4, ENSMUST00000058004.4

Conserved Domains (2) summary

cd14964
Location:20 → 44

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:18 → 302

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily